DPPA3
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.{{cite web | title = Entrez Gene: DPPA3 developmental pluripotency associated 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=359787| accessdate = }}
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
References
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Further reading
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- {{cite journal | vauthors=Nakamura T, Arai Y, Umehara H |title=PGC7/Stella protects against DNA demethylation in early embryogenesis. |journal=Nat. Cell Biol. |volume=9 |issue= 1 |pages= 64–71 |year= 2007 |pmid= 17143267 |doi= 10.1038/ncb1519 |s2cid=1947132 |display-authors=etal}}
- {{cite journal | vauthors=Elliman SJ, Wu I, Kemp DM |title=Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. |journal=J. Biol. Chem. |volume=281 |issue= 1 |pages= 16–9 |year= 2006 |pmid= 16291741 |doi= 10.1074/jbc.C500415200 |doi-access= free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Bortvin A, Goodheart M, Liao M, Page DC |title=Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. |journal=BMC Dev. Biol. |volume=4|pages= 2 |year= 2004 |pmid= 15018652 |doi= 10.1186/1471-213X-4-2 | pmc=362866 |doi-access=free }}
- {{cite journal | vauthors=Clark AT, Rodriguez RT, Bodnar MS |title=Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. |journal=Stem Cells |volume=22 |issue= 2 |pages= 169–79 |year= 2004 |pmid= 14990856 |doi=10.1634/stemcells.22-2-169 |s2cid=38136098 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Bowles J, Teasdale RP, James K, Koopman P |title=Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. |journal=Cytogenet. Genome Res. |volume=101 |issue= 3–4 |pages= 261–5 |year= 2004 |pmid= 14684992 |doi= 10.1159/000074346 |s2cid=7005986 }}
- {{cite journal | vauthors=Payer B, Saitou M, Barton SC |title=Stella is a maternal effect gene required for normal early development in mice |journal=Curr. Biol. |volume=13 |issue= 23 |pages= 2110–7 |year= 2004 |pmid= 14654002 |doi=10.1016/j.cub.2003.11.026 |s2cid=2010581 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Sato M, Kimura T, Kurokawa K |title=Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells |journal=Mech. Dev. |volume=113 |issue= 1 |pages= 91–4 |year= 2002 |pmid= 11900980 |doi=10.1016/S0925-4773(02)00002-3 |s2cid=12877378 |display-authors=etal|doi-access= }}
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