DPYSL2
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.{{cite journal | vauthors = Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M | title = A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution | journal = Gene | volume = 180 | issue = 1–2 | pages = 157–63 |date=Jan 1997 | pmid = 8973361 | doi =10.1016/S0378-1119(96)00445-3 }}{{cite web | title = Entrez Gene: DPYSL2 dihydropyrimidinase-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1808}}
Interactions
DPYSL2 has been shown to interact with CRMP1,{{cite journal |last=Leung |first=Thomas |author2=Ng Yvonne |author3=Cheong Albert |author4=Ng Chong Han |author5=Tan Ivan |author6=Hall Christine |author7=Lim Louis |date=Dec 2002 |title=p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology |journal=FEBS Lett. |volume=532 |issue=3 |pages=445–9 |location = Netherlands| issn = 0014-5793| pmid = 12482610 | doi = 10.1016/S0014-5793(02)03736-5 |s2cid=45499981 |doi-access=free }} Adaptor-related protein complex 2, alpha 1{{cite journal |last=Nishimura |first=Takashi |author2=Fukata Yuko |author3=Kato Katsuhiro |author4=Yamaguchi Tomoya |author5=Matsuura Yoshiharu |author6=Kamiguchi Hiroyuki |author7=Kaibuchi Kozo |date=Sep 2003 |title=CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth |journal=Nat. Cell Biol. |volume=5 |issue=9 |pages=819–26 |location = England| issn = 1465-7392| pmid = 12942088 |doi = 10.1038/ncb1039 |s2cid=12118386 }} and NUMB.
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
- {{cite journal | vauthors=Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM |title=Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33 |journal=Nature |volume=376 |issue= 6540 |pages= 509–14 |year= 1995 |pmid= 7637782 |doi= 10.1038/376509a0 |bibcode=1995Natur.376..509G |s2cid=4309140 }}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Roberts RG, Freeman TC, Kendall E |title=Characterization of DRP2, a novel human dystrophin homologue |journal=Nat. Genet. |volume=13 |issue= 2 |pages= 223–6 |year= 1996 |pmid= 8640231 |doi= 10.1038/ng0696-223 |s2cid=20939305 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Kitamura K, Takayama M, Hamajima N |title=Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene |journal=DNA Res. |volume=6 |issue= 5 |pages= 291–7 |year= 2000 |pmid= 10574455 |doi=10.1093/dnares/6.5.291 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gu Y, Hamajima N, Ihara Y |title=Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522 |journal=Biochemistry |volume=39 |issue= 15 |pages= 4267–75 |year= 2000 |pmid= 10757975 |doi=10.1021/bi992323h }}
- {{cite journal | vauthors=Gu Y, Ihara Y |title=Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 17917–20 |year= 2000 |pmid= 10770920 |doi= 10.1074/jbc.C000179200 |doi-access= free }}
- {{cite journal | vauthors=Arimura N, Inagaki N, Chihara K |title=Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23973–80 |year= 2000 |pmid= 10818093 |doi= 10.1074/jbc.M001032200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Fukada M, Watakabe I, Yuasa-Kawada J |title=Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37957–65 |year= 2001 |pmid= 10956643 |doi= 10.1074/jbc.M003277200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Santolini E, Puri C, Salcini AE |title=Numb Is an Endocytic Protein |journal=J. Cell Biol. |volume=151 |issue= 6 |pages= 1345–52 |year= 2001 |pmid= 11121447 |doi=10.1083/jcb.151.6.1345 | pmc=2190585 |display-authors=etal}}
- {{cite journal | vauthors=Lee S, Kim JH, Lee CS |title=Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6542–9 |year= 2002 |pmid= 11741937 |doi= 10.1074/jbc.M108047200 |display-authors=etal|doi-access=free }}
- {{cite book | vauthors=Weitzdoerfer R, Fountoulakis M, Lubec G |chapter=Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain |title=Protein Expression in Down Syndrome Brain |journal=Journal of Neural Transmission. Supplementum |issue= 61 |pages= 95–107 |year= 2002 |pmid= 11771764 |doi= 10.1007/978-3-7091-6262-0_8|isbn=978-3-211-83704-7 }}
- {{cite journal | vauthors=Fukata Y, Itoh TJ, Kimura T |title=CRMP-2 binds to tubulin heterodimers to promote microtubule assembly |journal=Nat. Cell Biol. |volume=4 |issue= 8 |pages= 583–91 |year= 2002 |pmid= 12134159 |doi= 10.1038/ncb825 |s2cid=22934366 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Leung T, Ng Y, Cheong A |title=p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology |journal=FEBS Lett. |volume=532 |issue= 3 |pages= 445–9 |year= 2003 |pmid= 12482610 |doi=10.1016/S0014-5793(02)03736-5 |s2cid=45499981 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Nishimura T, Fukata Y, Kato K |title=CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth |journal=Nat. Cell Biol. |volume=5 |issue= 9 |pages= 819–26 |year= 2003 |pmid= 12942088 |doi= 10.1038/ncb1039 |s2cid=12118386 |display-authors=etal}}
- {{cite journal | vauthors=Nakata K, Ujike H, Tanaka Y |title=No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans |journal=Neurosci. Lett. |volume=349 |issue= 3 |pages= 171–4 |year= 2003 |pmid= 12951196 |doi=10.1016/S0304-3940(03)00824-3 |s2cid=30637558 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
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{{PDB Gallery|geneid=1808}}
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