DSP-4
For the Super NES enhancement chip see List of Super NES enhancement chips
{{chembox
| Verifiedfields =
| verifiedrevid =
| ImageFile=DSP-4.svg
| ImageSize=200px
| PIN=N-[(2-Bromophenyl)methyl]-2-chloro-N-ethylethan-1-amine
| OtherNames=
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref =
| ChemSpiderID = 3060
| InChI = 1S/C11H15BrClN/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12/h3-6H,2,7-9H2, 1H3
| InChIKey = SDJLVPMBBFRBLL-UHFFFAOYSA-N
| ChEMBL_Ref =
| ChEMBL =
| StdInChI_Ref =
| StdInChI =
| StdInChIKey_Ref =
| StdInChIKey =
| CASNo = 62078-98-2
| CASNo_Ref = {{cascite|correct|CAS}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = PQ1P7JP5C1
| PubChem= 3172
| KEGG_Ref =
| KEGG =
| SMILES = CCN(CCCl)CC1=CC=CC=C1Br
}}
|Section2={{Chembox Properties
| Formula= C11H15BrClN
| MolarMass = 276.60 g/mol
| Appearance=
| Density= 1.339 g/cm3
| MeltingPt=
| BoilingPt=
| Solubility=
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|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
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DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a monoaminergic neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.{{cite journal |vauthors=Daw NW, Videen TO, Parkinson D, Rader RK |title=DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation |journal=J. Neurosci. |volume=5 |issue=7 |pages=1925–1933 |year=1985 |pmid=3926960 |doi=10.1523/jneurosci.05-07-01925.1985|pmc=6565098 |doi-access=free }}
It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.{{cite journal |vauthors=Jaim-Etcheverry G, Mari'a Zieher L |title=DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats |journal=Brain Res. |volume=188 |issue=2 |pages=513–523 |year=1980 |pmid=7370771 |doi=10.1016/0006-8993(80)90049-9|s2cid=36955590 }}
See also
References
{{Reflist}}
{{Monoamine neurotoxins}}
{{Nitrogen mustards}}
Category:2-Bromophenyl compounds
Category:Chloroethyl compounds
Category:Monoaminergic neurotoxins
{{Neurotoxin-stub}}