DSP-4

For the Super NES enhancement chip see List of Super NES enhancement chips

{{chembox

| Verifiedfields =

| verifiedrevid =

| ImageFile=DSP-4.svg

| ImageSize=200px

| PIN=N-[(2-Bromophenyl)methyl]-2-chloro-N-ethylethan-1-amine

| OtherNames=

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref =

| ChemSpiderID = 3060

| InChI = 1S/C11H15BrClN/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12/h3-6H,2,7-9H2, 1H3

| InChIKey = SDJLVPMBBFRBLL-UHFFFAOYSA-N

| ChEMBL_Ref =

| ChEMBL =

| StdInChI_Ref =

| StdInChI =

| StdInChIKey_Ref =

| StdInChIKey =

| CASNo = 62078-98-2

| CASNo_Ref = {{cascite|correct|CAS}}

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = PQ1P7JP5C1

| PubChem= 3172

| KEGG_Ref =

| KEGG =

| SMILES = CCN(CCCl)CC1=CC=CC=C1Br

}}

|Section2={{Chembox Properties

| Formula= C11H15BrClN

| MolarMass = 276.60 g/mol

| Appearance=

| Density= 1.339 g/cm3

| MeltingPt=

| BoilingPt=

| Solubility=

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|Section3={{Chembox Hazards

| MainHazards=

| FlashPt=

| AutoignitionPt =

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DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a monoaminergic neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.{{cite journal |vauthors=Daw NW, Videen TO, Parkinson D, Rader RK |title=DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation |journal=J. Neurosci. |volume=5 |issue=7 |pages=1925–1933 |year=1985 |pmid=3926960 |doi=10.1523/jneurosci.05-07-01925.1985|pmc=6565098 |doi-access=free }}

It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.{{cite journal |vauthors=Jaim-Etcheverry G, Mari'a Zieher L |title=DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats |journal=Brain Res. |volume=188 |issue=2 |pages=513–523 |year=1980 |pmid=7370771 |doi=10.1016/0006-8993(80)90049-9|s2cid=36955590 }}

See also

References