DTX2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.{{cite web | title = Entrez Gene: DTX2 deltex homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113878| accessdate = }}
DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.{{cite journal | vauthors = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21930–7 | year = 2003 | pmid = 12670957 | doi = 10.1074/jbc.M301157200 | doi-access = free }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | author=Matsuno K |title=Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats |journal=Development |volume=121 |issue= 8 |pages= 2633–44 |year= 1995 |pmid= 7671825 |name-list-style=vanc| author2=Diederich RJ | author3=Go MJ | display-authors=3 | last4=Blaumueller | first4=CM | last5=Artavanis-Tsakonas | first5=S |doi=10.1242/dev.121.8.2633 }}
- {{cite journal | author=Kishi N |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21–35 |year= 2001 |pmid= 11226752 |doi=10.1016/S0736-5748(00)00071-X |name-list-style=vanc| author2=Tang Z | author3=Maeda Y | display-authors=3 | last4=Hirai | first4=Asami | last5=Mo | first5=Rong | last6=Ito | first6=Mikiko | last7=Suzuki | first7=Satoshi | last8=Nakao | first8=Keiko | last9=Kinoshita | first9=Tsutomu |s2cid=21859491 }}
- {{cite journal | author=Yamamoto N |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031–40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 |name-list-style=vanc| author2=Yamamoto S | author3=Inagaki F | display-authors=3 | last4=Kawaichi | first4=M | last5=Fukamizu | first5=A | last6=Kishi | first6=N | last7=Matsuno | first7=K | last8=Nakamura | first8=K | last9=Weinmaster | first9=G | doi-access=free }}
- {{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |name-list-style=vanc| author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | first4=3rd | last5=Hermeking | first5=H |doi-access=free }}
- {{cite journal | author=Hiller M |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 | pmc=1380236 |name-list-style=vanc| author2=Huse K | author3=Szafranski K | display-authors=3 | last4=Jahn | first4=Niels | last5=Hampe | first5=Jochen | last6=Schreiber | first6=Stefan | last7=Backofen | first7=Rolf | last8=Platzer | first8=Matthias }}
- {{cite journal | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-style=vanc| author2=Hao T | author3=Shaw C | display-authors=3 | last4=Patel | first4=Akash J | last5=Szabó | first5=Gábor | last6=Rual | first6=Jean-François | last7=Fisk | first7=C. Joseph | last8=Li | first8=Ning | last9=Smolyar | first9=Alex |s2cid=13709685 | doi-access=free }}
- {{cite journal | vauthors=Yi Z, Yi T, Wu Z |title=cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos |journal=DNA Seq. |volume=17 |issue= 3 |pages= 175–80 |year= 2007 |pmid= 17286044 |doi=10.1080/10425170600857616 |s2cid=26424595 }}
{{refend}}
External links
- {{MeshName|DTX2+protein,+human}}
{{NLM content}}
{{Transcription factors}}
Category:Transcription factors
{{gene-7-stub}}