DTYMK

{{Short description|Protein-coding gene in the species Homo sapiens}}

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.{{cite journal | vauthors = Su JY, Sclafani RA | title = Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast | journal = Nucleic Acids Res | volume = 19 | issue = 4 | pages = 823–7 |date=May 1991 | pmid = 2017365 | pmc = 333717 | doi =10.1093/nar/19.4.823 }}{{cite journal | vauthors = Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A | title = Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth | journal = DNA Cell Biol | volume = 13 | issue = 5 | pages = 461–71 |date=Aug 1994 | pmid = 8024690 | doi =10.1089/dna.1994.13.461 }}{{cite web | title = Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1841}} and belongs to thymidylate kinase family of proteins.

References

{{cite journal | vauthors=Van Rompay AR, Johansson M, Karlsson A |title=Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. |journal=Pharmacol. Ther. |volume=87 |issue= 2–3 |pages= 189–98 |year= 2000 |pmid= 11008000 |doi=10.1016/S0163-7258(00)00048-6 }}
{{cite journal | vauthors=Tamiya N, Yusa T, Yamaguchi Y |title=Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography. |journal=Biochim. Biophys. Acta |volume=995 |issue= 1 |pages= 28–35 |year= 1989 |pmid= 2538159 |doi=10.1016/0167-4838(89)90229-X |display-authors=etal}}
{{cite journal | vauthors=Cummins RR, Balinsky D |title=Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. |journal=Cancer Res. |volume=40 |issue= 4 |pages= 1235–9 |year= 1980 |pmid= 6244089 }}
{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Ostermann N, Segura-Peña D, Meier C |title=Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. |journal=Biochemistry |volume=42 |issue= 9 |pages= 2568–77 |year= 2003 |pmid= 12614151 |doi= 10.1021/bi027302t |display-authors=etal}}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

DTYMK

References

Further reading