DUSP16
{{Short description|Protein-coding gene in humans}}
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Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.{{cite journal | vauthors = Tanoue T, Yamamoto T, Maeda R, Nishida E | title = A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs | journal = J Biol Chem | volume = 276 | issue = 28 | pages = 26629–39 |date=Jul 2001 | pmid = 11359773 | doi = 10.1074/jbc.M101981200 | doi-access = free }}{{cite journal | vauthors = Masuda K, Shima H, Watanabe M, Kikuchi K | title = MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein | journal = J Biol Chem | volume = 276 | issue = 42 | pages = 39002–11 |date=Oct 2001 | pmid = 11489891 | doi = 10.1074/jbc.M104600200 | doi-access = free }}{{cite journal | vauthors = Willoughby EA, Collins MK | title = Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2 | journal = J Biol Chem | volume = 280 | issue = 27 | pages = 25651–8 |date=Jul 2005 | pmid = 15888437 | doi = 10.1074/jbc.M501926200 | doi-access = free }}{{cite web | title = Entrez Gene: DUSP16 dual specificity phosphatase 16| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80824}}
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]
Interactions
DUSP16 has been shown to interact with MAPK14{{cite journal |last=Tanoue |first=T |author2=Yamamoto T |author3=Maeda R |author4=Nishida E |date=Jul 2001 |title=A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs |journal=J. Biol. Chem. |volume=276 |issue=28 |pages=26629–39 |location = United States| issn = 0021-9258| pmid = 11359773 |doi = 10.1074/jbc.M101981200 |doi-access=free }}{{cite journal |last=Masuda |first=K |author2=Shima H |author3=Watanabe M |author4=Kikuchi K |date=Oct 2001 |title=MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=39002–11 |location = United States| issn = 0021-9258| pmid = 11489891 |doi = 10.1074/jbc.M104600200 |doi-access=free }} and MAPK8IP1.{{cite journal |last=Willoughby |first=Emma A |author2=Perkins Gordon R |author3=Collins Mary K |author4=Whitmarsh Alan J |date=Mar 2003 |title=The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK |journal=J. Biol. Chem. |volume=278 |issue=12 |pages=10731–6 |location = United States| issn = 0021-9258| pmid = 12524447 |doi = 10.1074/jbc.M207324200 |doi-access=free }}
References
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Further reading
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- {{cite journal | vauthors=Nagase T, Kikuno R, Hattori A |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ |title=The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10731–6 |year= 2003 |pmid= 12524447 |doi= 10.1074/jbc.M207324200 |doi-access= free }}
- {{cite journal | vauthors=Masuda K, Shima H, Katagiri C, Kikuchi K |title=Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32448–56 |year= 2003 |pmid= 12794087 |doi= 10.1074/jbc.M213254200 |doi-access= free }}
- {{cite journal | vauthors=Hoornaert I, Marynen P, Goris J |title=MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. |journal=Oncogene |volume=22 |issue= 49 |pages= 7728–36 |year= 2003 |pmid= 14586399 |doi= 10.1038/sj.onc.1207089 |display-authors=etal|doi-access= |s2cid=20321362 }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Katagiri C, Masuda K, Urano T |title=Phosphorylation of Ser-446 determines stability of MKP-7. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14716–22 |year= 2005 |pmid= 15689616 |doi= 10.1074/jbc.M500200200 |display-authors=etal|doi-access=free }}
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External links
- [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9BY84 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16
{{Protein tyrosine phosphatases}}
{{gene-12-stub}}