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DUSP7

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.{{cite journal | vauthors = Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S | title = MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase | journal = J Biol Chem | volume = 271 | issue = 8 | pages = 4319–26 |date=Jun 1996 | pmid = 8626780 | doi =10.1074/jbc.271.8.4319 | doi-access = free }}{{cite journal | vauthors = Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A | title = Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7) | journal = Genomics | volume = 42 | issue = 3 | pages = 524–7 |date=Sep 1997 | pmid = 9205128 | doi = 10.1006/geno.1997.4756 }}{{cite web | title = Entrez Gene: DUSP7 dual specificity phosphatase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1849}}

Function

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to de-phosphorylate both tyrosine ({{EC number|3.1.3.48}}) and serine / threonine ({{EC number|3.1.3.16}}) residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.{{cite journal | vauthors = Patterson KI, Brummer T, O'Brien PM, Daly RJ | title = Dual-specificity phosphatases: critical regulators with diverse cellular targets | journal = Biochem. J. | volume = 418 | issue = 3 | pages = 475–89 |date=March 2009 | pmid = 19228121 | doi = 10.1042/bj20082234}}

It is known to bind and dephosphorylate ErkII, and as it, along with the other members of the DUSP family expresses high selectively for MAP kinases, it has been suggested that it functions as a method for selectively activating/deactivating different members of that family.{{cite journal | vauthors = Dowd S, Sneddon AA, Keyse SM | title = Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases | journal = J. Cell Sci. | volume = 111 | issue = 22| pages = 3389–99 |date=November 1998 | doi = 10.1242/jcs.111.22.3389 | pmid = 9788880 | url = http://jcs.biologists.org/content/111/22/3389.abstract }}

References

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Further reading

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  • {{cite journal | author=Groom LA |title=Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase |journal=EMBO J. |volume=15 |issue= 14 |pages= 3621–32 |year= 1996 |pmid= 8670865 |doi= 10.1002/j.1460-2075.1996.tb00731.x| pmc=451978 | author2=Sneddon AA | author3=Alessi DR | last4=Dowd | first4=S | last5=Keyse | first5=SM }}
  • {{cite journal | vauthors=Dowd S, Sneddon AA, Keyse SM |title=Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases |journal=J. Cell Sci. |volume=111 |issue= 22|pages= 3389–99 |year= 1999 |doi=10.1242/jcs.111.22.3389 |pmid= 9788880 |url=http://jcs.biologists.org/content/111/22/3389.abstract }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Pasquali C |title=Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor |journal=Mol. Endocrinol. |volume=17 |issue= 11 |pages= 2228–39 |year= 2004 |pmid= 12907755 |doi= 10.1210/me.2003-0011 | author2=Curchod ML | author3=Wälchli S | last4=Espanel | first4=X | last5=Guerrier | first5=M | last6=Arigoni | first6=F | last7=Strous | first7=G | last8=Hooft Van Huijsduijnen | first8=R | doi-access=free }}
  • {{cite journal | author=Levy-Nissenbaum O |title=Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells |journal=Oncogene |volume=22 |issue= 48 |pages= 7649–60 |year= 2003 |pmid= 14576828 |doi= 10.1038/sj.onc.1206971 | author2=Sagi-Assif O | author3=Kapon D | last4=Hantisteanu | first4=Shay | last5=Burg | first5=Tamar | last6=Raanani | first6=Pia | last7=Avigdor | first7=Abraham | last8=Ben-Bassat | first8=Isaac | last9=Witz | first9=Isaac P | doi-access=free }}
  • {{cite journal | vauthors=Levy-Nissenbaum O, Sagi-Assif O, Witz IP |title=Characterization of the dual-specificity phosphatase PYST2 and its transcripts |journal=Genes Chromosomes Cancer |volume=39 |issue= 1 |pages= 37–47 |year= 2004 |pmid= 14603440 |doi= 10.1002/gcc.10295 |s2cid=11333674 }}
  • {{cite book | author=Levy-Nissenbaum O |volume=366 |pages= 103–13 |year= 2004 |pmid= 14674243 |doi=10.1016/S0076-6879(03)66009-X | author2=Sagi-Assif O | author3=Raanani P | series=Methods in Enzymology | last4=Avigdor | first4=Abraham | last5=Ben-Bassat | first5=Isaac | last6=Witz | first6=Isaac P |title=Protein Phosphatases |chapter=CDNA Microarray Analysis Reveals an Overexpression of the Dual-Specificity MAPK Phosphatase PYST2 in Acute Leukemia | isbn=978-0-12-182269-9 }}
  • {{cite journal | author=Orlev LN |title=Does the dual-specificity MAPK phosphatase Pyst2-L lead a monogamous relationship with the Erk2 protein? |journal=Immunol. Lett. |volume=92 |issue= 1–2 |pages= 149–56 |year= 2004 |pmid= 15081539 |doi= 10.1016/j.imlet.2003.11.024 | author2=Ehud B | author3=Tamar BG | last4=Orit | first4=Sagi-Assif | last5=Yoel | first5=Kloog | last6=Witz | first6=Isaac P. }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

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External links

  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q16829 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 7 (DUSP7)

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{{Protein tyrosine phosphatases}}

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Category:EC 3.1.3