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DYRK3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.{{cite journal | vauthors = Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG | title = Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases | journal = J Biol Chem | volume = 273 | issue = 40 | pages = 25893–902 |date=Nov 1998 | pmid = 9748265 | doi =10.1074/jbc.273.40.25893 | doi-access = free }}{{cite web | title = Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8444}}

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.

See also

References

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Further reading

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  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Zhang D, Li K, Erickson-Miller CL |title=DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. |journal=Genomics |volume=85 |issue= 1 |pages= 117–30 |year= 2005 |pmid= 15607427 |doi= 10.1016/j.ygeno.2004.08.021 |display-authors=etal}}
  • {{cite journal | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Li K, Zhao S, Karur V, Wojchowski DM |title=DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47052–60 |year= 2003 |pmid= 12356771 |doi= 10.1074/jbc.M205374200 |doi-access= free }}
  • {{cite journal | vauthors=Lord KA, Creasy CL, King AG |title=REDK, a novel human regulatory erythroid kinase. |journal=Blood |volume=95 |issue= 9 |pages= 2838–46 |year= 2000 |doi=10.1182/blood.V95.9.2838.009k29_2838_2846 |pmid= 10779429 |display-authors=etal}}
  • {{cite journal | vauthors=Xia J, Yang X, Ruan Q |title=[Molecular cloning and characterization of novel protein kinase gene DYRK3] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=15 |issue= 6 |pages= 327–32 |year= 1999 |pmid= 9845759 |display-authors=etal}}

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