Dachshund (gene)

{{short description|Gene involved in developing the arthropod compound eye}}

{{Infobox nonhuman protein

|UniProt=Q24030

|Organism=Drosophila melanogaster

|Name=Dachshund

|Symbol=dac}}

dachshund (dac) is a gene involved in the development of the arthropod compound eye{{cite journal | vauthors = Mardon G, Solomon NM, Rubin GM | title = dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila | journal = Development | volume = 120 | issue = 12 | pages = 3473–86 | date = December 1994 | doi = 10.1242/dev.120.12.3473 | pmid = 7821215 }} which also plays a role in leg development.{{cite journal | vauthors = Gehring WJ, Ikeo K | title = Pax 6: mastering eye morphogenesis and eye evolution | journal = Trends in Genetics | volume = 15 | issue = 9 | pages = 371–7 | date = September 1999 | pmid = 10461206 | doi = 10.1016/S0168-9525(99)01776-X }} It is activated by the Distal-less (Dll) gene.{{cite book | vauthors = Estella C, Voutev R, Mann RS | title = Transcriptional Switches During Development | chapter = A Dynamic Network of Morphogens and Transcription Factors Patterns the Fly Leg | series = Current Topics in Developmental Biology | volume = 98 | pages = 173–98 | date = 2012-01-01 | pmid = 22305163 | pmc = 3918458 | doi = 10.1016/B978-0-12-386499-4.00007-0 | isbn = 9780123864994 }}

Dachshund homologue (DACH1) regulates tumorigenesis in humans as a part of the Retinal Determination Gene Network (RDGN) complex, with cancer patients showing altered DACH1 expression.{{cite journal | vauthors = Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG | title = The Dachshund gene in development and hormone-responsive tumorigenesis | journal = Trends in Endocrinology and Metabolism | volume = 21 | issue = 1 | pages = 41–9 | date = January 2010 | pmid = 19896866 | pmc = 2818438 | doi = 10.1016/j.tem.2009.08.002 }} Its homologs form the SKI/SNO/DAC family ({{Pfam|PF02437}}).