Daniel Herschlag
{{Short description|American biochemist}}
{{Infobox scientist
| name = Daniel Herschlag
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| birth_date = {{Birth date and age|1958|10|16}}
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| nationality = American
| fields = Biochemistry
| workplaces = Stanford University
| alma_mater = Binghamton University, Brandeis University, University of Colorado at Boulder
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| doctoral_advisor = William Jencks
| academic_advisors = Tom Cech
| doctoral_students = Rhiju Das Geeta Narlikar
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| known_for = Enzymology RNA biochemistry
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| awards = William C. Rose Award (2010)
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Daniel Herschlag (born October 16, 1958) is an American biochemist and Professor of Biochemistry at the Stanford University School of Medicine. His research uses an interdisciplinary approach to advance our understanding of the fundamental behavior of RNA and proteins. He is well known for his application of rigorous kinetic and mechanistic approaches to RNA and protein systems.{{cite news|title=Daniel Herschlag named this year's William C. Rose Award winner|url=http://www.asbmb.org/Meetings_01/2010mtg/2010mtgint.aspx?id=3898|accessdate=7 April 2013|newspaper=ASBMB|archive-date=9 November 2012|archive-url=https://web.archive.org/web/20121109162504/http://www.asbmb.org/Meetings_01/2010mtg/2010mtgint.aspx?id=3898|url-status=dead}}
Education
Herschlag received a B.S. degree in biochemistry from Binghamton University in 1982. He began his graduate studies at University of Minnesota then moved on to complete his Ph.D. degree in Biochemistry at Brandeis University under W.P. Jencks in 1988.{{cite news|title=Meet Dr. Herschlag from Stanford University|url=http://news.cos.ucf.edu/?p=4576|accessdate=7 April 2013|newspaper=UCSF|date=6 September 2012}}
Career
Herschlag was a Helen Hay Whitney Postdoctoral Fellow at the University of Colorado at Boulder from 1989 to 1992.{{cite web|title=Helen Hay Whitney Foundation award list|url=http://www.hhwf.org/Dir/detail.php?id=301|url-status=dead|archiveurl=https://web.archive.org/web/20160304043300/http://www.hhwf.org/Dir/detail.php?id=301|archivedate=2016-03-04}} He conducted post-doctoral research on the mechanism of the newly discovered RNA self-splicing reaction in the lab of Tom Cech.
In 1992, Herschlag joined the faculty of the Department of Biochemistry in the Stanford University School of Medicine, earning tenure in 1997. He was promoted to full professor in 2002.
In 2011, he was appointed the Senior Associate Dean of Graduate Education and Postdoctoral Affairs for the Stanford University School of Medicine.{{cite web|title=Stanford Dean's Newsletter|url=http://deansnewsletter.stanford.edu/archive/07_25_11.html#12|access-date=2012-10-14|archive-date=2013-01-25|archive-url=https://web.archive.org/web/20130125214556/http://deansnewsletter.stanford.edu/archive/07_25_11.html#12|url-status=dead}}{{cite web|title=Stanford University School of Medicine Leadership List|url=http://med.stanford.edu/leadership/senior_deans.html|access-date=2012-10-14|archive-url=https://web.archive.org/web/20121014131419/http://med.stanford.edu/leadership/senior_deans.html|archive-date=2012-10-14|url-status=dead}}
Selected awards
- Pfizer Award in Enzyme Chemistry, 1997{{cite web|title=Pfizer Awardees List|url=http://www.divbiolchem.org/content/pfizerawardees1.pdf|access-date=2012-10-14|archive-date=2017-01-01|archive-url=https://web.archive.org/web/20170101193005/http://www.divbiolchem.org/content/pfizerawardees1.pdf|url-status=dead}}
- Cope Scholar Award from the American Chemical Society, 2000{{cite web|title=Cope Scholar Award Announcement|url=http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1319&content_id=CTP_004496&use_sec=true&sec_url_var=region1&__uuid=1462d5f0-9d3f-4086-b823-af7b598205da}}
- ASBMB William Rose Award, 2010{{cite web|title=ASBMB William Rose award announcement|url=http://www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=5876}}
- National Academy of Sciences Inductee, 2018{{Cite web|url=http://www.nasonline.org/member-directory/members/20041818.html|title=Dan Herschlag|website=www.nasonline.org|access-date=2020-01-31}}{{Cite web|url=https://news.stanford.edu/2018/05/02/three-stanford-faculty-elected-national-academy-sciences/|title=Three Stanford faculty elected to the National Academy of Sciences|last=University|first=Stanford|date=2018-05-02|website=Stanford News|language=en|access-date=2020-01-31}}
- Biophysical Society Founders Award, 2020{{Cite web|url=https://www.biophysics.org/news-room/dan-herschlag-to-receive-biophysical-societys-2020-founders-award|title=Dan Herschlag to Receive Biophysical Society's 2020 Founders Award|website=The Biophysical Society|language=en-US|access-date=2020-01-31}}{{Cite web|url=https://www.binghamton.edu/alumni/news-and-learning/alumni-connect/february-2020/chaperoningaccolades.html|title=RNA chaperoning earns alumnus science accolades – Alumni Association {{!}} Binghamton University|website=Alumni Association - Binghamton University|language=en|access-date=2020-02-15}}
Selected publications
- {{cite journal |doi=10.1038/344405a0 |title=DNA cleavage catalysed by the ribozyme from Tetrahymena |year=1990 |last1=Herschlag |first1=Daniel |last2=Cech |first2=Thomas R. |journal=Nature |volume=344 |issue=6265 |pages=405–9 |pmid=1690858|bibcode = 1990Natur.344..405H |s2cid=4242188 }}
- {{cite journal |pmid=7545662 |year=1995 |last1=Herschlag |first1=Daniel |title=RNA Chaperones and the RNA Folding Problem |volume=270 |issue=36 |pages=20871–4 |journal=The Journal of Biological Chemistry |doi=10.1074/jbc.270.36.20871 |doi-access=free }}
- {{cite journal |doi=10.1016/S1074-5521(99)80033-7 |title=Catalytic promiscuity and the evolution of new enzymatic activities |year=1999 |last1=O'Brien |first1=Patrick J |last2=Herschlag |first2=Daniel |journal=Chemistry & Biology |volume=6 |issue=4 |pmid=10099128 |pages=R91–R105|doi-access=free }}
- {{cite journal |doi=10.1073/pnas.221593598 |title=Exploring the Folding Landscape of a Structured RNA |year=2001 |journal=Proceedings of the National Academy of Sciences |volume=99 |first1=Rick |last1=Russell |first2=Xiaowei |last2=Zhuang |first3=Hazen P. |last3=Babcock |first4=Ian S. |last4=Millett |first5=Sebastian |last5=Doniach |first6=Steven |last6=Chu |first7=Daniel |last7=Herschlag |jstor=3057508 |bibcode=2002PNAS...99..155R |pmid=11756689 |pages=155–60 |issue=1 |pmc=117531|doi-access=free }}
- {{cite journal |doi=10.1021/ja056528r |title=Alkaline Phosphatase Mono- and Diesterase Reactions: Comparative Transition State Analysis |year=2006 |last1=Zalatan |first1=Jesse G. |last2=Herschlag |first2=Daniel |journal=Journal of the American Chemical Society |volume=128 |issue=4 |pages=1293–303 |pmid=16433548 |pmc=2538955}}
- {{cite journal |doi=10.1038/nature08717 |title=Multiple native states reveal persistent ruggedness of an RNA folding landscape |year=2010 |last1=Solomatin |first1=Sergey V. |last2=Greenfeld |first2=Max |last3=Chu |first3=Steven |last4=Herschlag |first4=Daniel |journal=Nature |volume=463 |issue=7281 |pages=681–4 |pmid=20130651 |pmc=2818749|bibcode = 2010Natur.463..681S }}
- {{cite journal |doi=10.1073/pnas.2220485120 |title=Dissecting the energetic architecture within an RNA tertiary structural motif via high-throughput thermodynamic measurements. |year=2023 |last1=Shin |first1=John H. |last2=Bonilla |first2=Steve L. |last3=Denny |first3=Sarah K. |last4=Greenleaf |first4=William J. |last5=Herschlag |first5=Daniel |journal=Proc Natl Acad Sci U S A |volume=120 |issue=11 |pages=e2220485120 |pmid=36897989 |pmc=10243134 |bibcode=2023PNAS..12020485S }}
Personal
Herschlag currently lives in Menlo Park, CA with his wife and two children.
See also
References
{{Reflist}}
External links
- [http://herschlaglab.stanford.edu/ Herschlag Lab Website]
- [http://biochem.stanford.edu/ Stanford University School of Medicine Biochemistry Department]
- [http://med.stanford.edu/profiles/Daniel_Herschlag/ Stanford Community Academic Profile, Daniel Herschlag]
{{Pfizer Award in Enzyme Chemistry}}
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Category:Stanford University School of Medicine faculty
Category:21st-century American biochemists
Category:Brandeis University alumni
Category:Binghamton University alumni
Category:Fellows of the American Association for the Advancement of Science