Daniel L. Kastner

Kastner was born in Lockport, New York, in 1951.

Kastner earned a BA in philosophy from Princeton University in 1973. and an MD and PhD from Baylor College of Medicine.

Kastner joined the National Institutes of Health in 1985 and {{as of |2020|lc=yes}} is scientific director of the Division of Intramural Research of the National Human Genome Research Institute. His research there "has focused on using genetic and genomic strategies to understand inherited disorders of inflammation".

His work has led to the recognition and treatment of a range of autoinflammatory disorders. In 1987 his was one of two teams which simultaneously discovered and published the genetic mutation which causes FMF, and since then he has worked on disorders including TRAPS and DADA2. In 2020 he was one of the authors of the paper which first described the VEXAS syndrome.{{cite web |title=VEXAS: how a deadly disease was discovered |url=https://www.thenakedscientists.com/articles/interviews/vexas-how-deadly-disease-was-discovered |website=www.thenakedscientists.com |access-date=27 December 2020 |language=en |date=13 November 2020 |archive-date=16 March 2021 |archive-url=https://web.archive.org/web/20210316090424/https://www.thenakedscientists.com/articles/interviews/vexas-how-deadly-disease-was-discovered |url-status=live }}{{cite journal |last1=Beck |first1=David B.|author-link1=David B. Beck |last2=Ferrada |first2=Marcela A. |last3=Sikora |first3=Keith A. |last4=Ombrello |first4=Amanda K. |last5=Collins |first5=Jason C. |last6=Pei |first6=Wuhong |last7=Balanda |first7=Nicholas |last8=Ross |first8=Daron L. |last9=Ospina Cardona |first9=Daniela |last10=Wu |first10=Zhijie |last11=Patel |first11=Bhavisha |last12=Manthiram |first12=Kalpana |last13=Groarke |first13=Emma M. |last14=Gutierrez-Rodrigues |first14=Fernanda |last15=Hoffmann |first15=Patrycja |last16=Rosenzweig |first16=Sofia |last17=Nakabo |first17=Shuichiro |last18=Dillon |first18=Laura W. |last19=Hourigan |first19=Christopher S. |last20=Tsai |first20=Wanxia L. |last21=Gupta |first21=Sarthak |last22=Carmona-Rivera |first22=Carmelo |last23=Asmar |first23=Anthony J. |last24=Xu |first24=Lisha |last25=Oda |first25=Hirotsugu |last26=Goodspeed |first26=Wendy |last27=Barron |first27=Karyl S. |last28=Nehrebecky |first28=Michele |last29=Jones |first29=Anne |last30=Laird |first30=Ryan S. |last31=Deuitch |first31=Natalie |last32=Rowczenio |first32=Dorota |last33=Rominger |first33=Emily |last34=Wells |first34=Kristina V. |last35=Lee |first35=Chyi-Chia R. |last36=Wang |first36=Weixin |last37=Trick |first37=Megan |last38=Mullikin |first38=James |last39=Wigerblad |first39=Gustaf |last40=Brooks |first40=Stephen |last41=Dell’Orso |first41=Stefania |last42=Deng |first42=Zuoming |last43=Chae |first43=Jae J. |last44=Dulau-Florea |first44=Alina |last45=Malicdan |first45=May C.V. |last46=Novacic |first46=Danica |last47=Colbert |first47=Robert A. |last48=Kaplan |first48=Mariana J. |last49=Gadina |first49=Massimo |last50=Savic |first50=Sinisa |last51=Lachmann |first51=Helen J. |last52=Abu-Asab |first52=Mones |last53=Solomon |first53=Benjamin D. |last54=Retterer |first54=Kyle |last55=Gahl |first55=William A. |last56=Burgess |first56=Shawn M. |last57=Aksentijevich |first57=Ivona |last58=Young |first58=Neal S. |last59=Calvo |first59=Katherine R. |last60=Werner |first60=Achim |last61=Kastner |first61=Daniel L. |last62=Grayson |first62=Peter C. |display-authors=6 |title=Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease |journal=New England Journal of Medicine |date=27 October 2020 |volume=383 |issue=27 |pages=2628–2638 |doi=10.1056/NEJMoa2026834|pmid=33108101 |pmc=7847551 }} {{As of|2021}} he is working on Behçet's disease.

{{As of|2021}} Kastner has said that he plans to leave his post of scientific director at NHGRI "in the next few months". He will continue to work with the 3,000 patients in his clinic, and "find yet more disease genes, understand how they work, and develop new treatments."

The chair of the Crafoord Prize committee, {{ill|Olle Kämpe|sv}}, said in 2021:

Dan Kastner is often called the father of autoinflammatory diseases, a title that he thoroughly deserves. His discoveries have taught us a great deal about the immune system and its functions, contributing to effective treatments that reduce the symptoms of diseases from which patients previously suffered enormously, sometimes leading to premature death

Kastner was elected to the National Academy of Sciences in 2010{{cite web |title=Daniel L. Kastner |url=http://www.nasonline.org/member-directory/members/20022361.html |website=www.nasonline.org |publisher=National Academy of Sciences |access-date=27 December 2020 |archive-date=24 March 2019 |archive-url=https://web.archive.org/web/20190324142454/http://www.nasonline.org/member-directory/members/20022361.html |url-status=live }} and to the National Academy of Medicine in 2012.{{cite web |title=Daniel L. Kastner, M.D., Ph.D. |url=https://nam.edu/member/?member_id=nsbY3y8gA9sNjGp7SPvUyQ%3D%3D |publisher=National Academy of Medicine |access-date=27 December 2020}}

In 2018 Kastner was named "Federal Employee of the Year" in the Samuel J. Heyman Service to America Medals ("the Sammies").{{cite web |last1=Palmer |first1=Kiara S. |title=NHGRI Scientific Director Dan Kastner Named 2018 Federal Employee of the Year |url=https://www.genome.gov/news/news-release/NHGRI-Scientific-Director-Dan-Kastner-Named-2018-Federal-Employee-of-the-Year |website=Genome.gov |access-date=27 December 2020 |language=en |date=October 2, 2018 |archive-date=9 January 2021 |archive-url=https://web.archive.org/web/20210109154343/https://www.genome.gov/news/news-release/NHGRI-Scientific-Director-Dan-Kastner-Named-2018-Federal-Employee-of-the-Year |url-status=live }}{{cite web |last1= |title=Daniel L. Kastner, M.D., Ph.D. |url=https://servicetoamericamedals.org/honorees/daniel-l-kastner-m-d-ph-d/ |publisher=Samuel J. Heyman Service to America Medals |access-date=27 December 2020 |archive-date=14 January 2021 |archive-url=https://web.archive.org/web/20210114215449/https://servicetoamericamedals.org/honorees/daniel-l-kastner-m-d-ph-d/ |url-status=live }} and in 2019 he won the Ross Prize for Molecular Medicine.{{cite web |title=Ross Prize in Molecular Medicine: Past winners |url=https://molmed.biomedcentral.com/about/rossprize |website=Molecular Medicine |access-date=27 December 2020 |language=en |archive-date=12 August 2020 |archive-url=https://web.archive.org/web/20200812153135/https://molmed.biomedcentral.com/about/rossprize |url-status=live }}

He was awarded the 2021 Crafoord Prize in Polyarthritis, with the citation "for establishing the concept of autoinflammatory diseases".{{cite web |title=The Crafoord Prize in Polyarthritis 2021 |date=31 January 2021 |url=https://www.crafoordprize.se/press_release/the-crafoord-prize-in-polyarthritis-2021 |publisher=Crafoord Prize |access-date=1 February 2021 |archive-date=1 February 2021 |archive-url=https://web.archive.org/web/20210201132047/https://www.crafoordprize.se/press_release/the-crafoord-prize-in-polyarthritis-2021 |url-status=live }}{{cite news |last1=Hunt |first1=Katie |title=Mysterious untreatable fevers once devastated whole families. This doctor discovered what caused them |url=https://edition.cnn.com/2021/02/01/health/daniel-kastner-rare-diseases-autoinflammatory-scn/index.html?fbclid=IwAR23zJDi9g-rJxClJqB27VIv8cPgoYQ3VFcG11RNLwg18dzKLwz8hdPfb70 |access-date=4 February 2021 |work=CNN |date=2 February 2021}}

{{reflist}}

• {{official website|https://www.genome.gov/staff/Dan-Kastner-MD-PhD}}
• {{Google Scholar id|_J-vYPYAAAAJ}}

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{{DEFAULTSORT:Kastner, Dan}}

Category:1951 births

Category:Date of birth missing (living people)

Category:Place of birth missing (living people)

Category:Living people

Category:Princeton University alumni

Category:Baylor College of Medicine alumni

Category:National Institutes of Health people

Category:Members of the United States National Academy of Sciences

Category:Members of the National Academy of Medicine

Category:People from Lockport, New York

Category:American medical researchers

Category:American geneticists