David A. Eisner

Eisner was born in 1955 in Manchester, the son of the physicist and writer Herbert Eisner.{{Cite news|url=https://www.telegraph.co.uk/news/obituaries/science-obituaries/8668910/Herbert-Eisner.html|title=Herbert Eisner|journal=The Daily Telegraph|date=28 July 2011|access-date=17 November 2018|issn=0307-1235}}{{Cite journal|date=20 July 2010|title=European Perspectives|journal=Circulation|volume=122|issue=3|doi=10.1161/cir.0b013e3181e8eb7f|issn=0009-7322|doi-access=free}} After attending Manchester Grammar School, he received his B.A. in natural sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil. in physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

Following postdoctoral research at the University of Cambridge on the kinetics of the sodium pump{{cite journal | vauthors = Eisner DA, Richards DE | title = The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts | journal = The Journal of Physiology | volume = 319 | pages = 403–18 | year = 1981 | pmid = 7320919 | pmc = 1243847 | doi = 10.1113/jphysiol.1981.sp013917 }} in the laboratory of Ian Glynn, he took up a lectureship in the Department of Physiology at University College London in 1980. In 1990 he moved to The University of Liverpool as professor of veterinary biology. In 1999 he took up a chair of cardiac physiology at the University of Manchester and, in 2000, was awarded the BHF Chair of Cardiac Physiology.{{cite web|url=https://www.bhf.org.uk/research/our-top-professors/professor-david-eisner |title=BHF Professor David Eisner – heart attack and arrhythmias |publisher=British Heart Foundation |access-date=30 April 2017}}

Eisner was chair of the editorial board of The Journal of Physiology from 1997 to 2000{{cite web|url=http://www.physoc.org/sites/default/files/page/Past%20Officers.pdf |title=Past Officers of the Physiological Society (1876–2001) |publisher=physoc.org |access-date=30 April 2017}} and editor-in chief of the Journal of Molecular and Cellular Cardiology from 2007 to 2016. He was president of The Federation of European Physiological Societies (FEPS) from 2011-2015{{Cite web |title=Past Officers of FEPS |url=https://www.feps.org/past-officers-feps |access-date=2022-11-10 |website=www.feps.org}} and The Physiological Society from 2016 to 2018.

Eisner's early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction.{{cite journal | vauthors = Eisner DA, Lederer WJ, Vaughan-Jones RD | title = The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres | journal = The Journal of Physiology | volume = 317 | pages = 163–87 | date = August 1981 | pmid = 7310731 | pmc = 1246783 | doi = 10.1113/jphysiol.1981.sp013819 }} He then investigated the control of intracellular calcium concentration{{cite journal | vauthors = Allen DG, Eisner DA, Orchard CH | title = Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle | journal = The Journal of Physiology | volume = 350 | pages = 615–30 | date = May 1984 | pmid = 6747860 | pmc = 1199289 | doi = 10.1113/jphysiol.1984.sp015221 }} and its role in the production of arrhythmias.{{cite journal | vauthors = Orchard CH, Eisner DA, Allen DG | title = Oscillations of intracellular Ca2+ in mammalian cardiac muscle | journal = Nature | volume = 304 | issue = 5928 | pages = 735–8 | year = 1983 | pmid = 6888540 | doi = 10.1038/304735a0 | bibcode = 1983Natur.304..735O | s2cid = 4306804 }} He has identified the factors that regulate the calcium content of the sarcoplasmic reticulum{{cite journal | vauthors = Eisner DA, Trafford AW, Díaz ME, Overend CL, O'Neill SC | title = The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation | journal = Cardiovascular Research | volume = 38 | issue = 3 | pages = 589–604 | date = June 1998 | pmid = 9747428 | doi = 10.1016/s0008-6363(98)00062-5 | doi-access = free }}{{cite journal | vauthors = Trafford AW, Díaz ME, Eisner DA | title = Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current | journal = Circulation Research | volume = 88 | issue = 2 | pages = 195–201 | date = February 2001 | pmid = 11157672 | doi = 10.1161/01.res.88.2.195 | doi-access = free }} and how this is altered in disease.{{cite journal | vauthors = Kashimura T, Briston SJ, Trafford AW, Napolitano C, Priori SG, Eisner DA, Venetucci LA | title = In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves | journal = Circulation Research | volume = 107 | issue = 12 | pages = 1483–9 | date = December 2010 | pmid = 20966392 | doi = 10.1161/CIRCRESAHA.110.227744 | doi-access = free }} His recent research has focused on the control of diastolic calcium{{Cite journal|last1=Eisner|first1=David A.|last2=Caldwell|first2=Jessica L.|last3=Trafford|first3=Andrew W.|last4=Hutchings|first4=David C.|date=31 January 2020|title=The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications|journal=Circulation Research|volume=126|issue=3|pages=395–412|doi=10.1161/CIRCRESAHA.119.315891|pmid=31999537|pmc=7004450|issn=0009-7330|doi-access=free}}{{cite journal | vauthors = Sankaranarayanan R, Kistamás K, Greensmith DJ, Venetucci LA, Eisner DA | title = i regulates diastolic levels in rat ventricular myocytes | journal = The Journal of Physiology | volume = 595 | issue = 16 | pages = 5545–5555 | date = August 2017 | pmid = 28617952 | pmc = 5556151 | doi = 10.1113/JP274366 }} and the effects of calcium buffering.{{cite journal | vauthors = Smith GL, Eisner DA | title = Calcium Buffering in the Heart in Health and Disease | journal = Circulation | volume = 139 | issue = 20 | pages = 2358–2371 | date = May 2019 | pmid = 31082292 | pmc = 6520234 | doi = 10.1161/CIRCULATIONAHA.118.039329 }}{{Cite journal |last1=Eisner |first1=David |last2=Neher |first2=Erwin |last3=Taschenberger |first3=Holger |last4=Smith |first4=Godfrey |date=2023-06-16 |title=Physiology of intracellular calcium buffering |journal=Physiological Reviews |volume=103 |issue=4 |pages=2767–2845 |doi=10.1152/physrev.00042.2022 |issn=1522-1210 |pmid=37326298|doi-access=free |pmc=11550887 }} He has also written{{Cite journal|last=Eisner|first=D. A.|date=January 2018|title=Reproducibility of science: Fraud, impact factors and carelessness|journal=Journal of Molecular and Cellular Cardiology|volume=114|pages=364–368|doi=10.1016/j.yjmcc.2017.10.009|issn=1095-8584|pmc=6565841|pmid=29079076}} and spoken{{Cite web|url=https://www.youtube.com/watch?v=vAlDrx5IJ2c|title=Does the 'system' reward fraud?|last=|first=|date=17 April 2020|website=Youtube|url-status=live|archive-url=https://web.archive.org/web/20210625074011/https://www.youtube.com/watch?v=vAlDrx5IJ2c |archive-date=25 June 2021 |access-date=}} about scientific reproducibility and fraud.

Eisner is married to Susan Wray, professor of cellular and molecular physiology at the University of Liverpool, with whom he has three children.

Eisner was elected as a Fellow of The Academy of Medical Sciences in 1999{{cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-David-Eisner-0005695 |title=Professor David Eisner | The Academy of Medical Sciences |publisher=Acmedsci.ac.uk |access-date=30 April 2017}} and The International Society for Heart Research in 2001.{{cite web|url=http://www.ishrworld.org/?page=Fellows |title=Fellows of the ISHR |publisher=International Society for Heart Research |access-date=30 April 2017}} and as a Member of Academia Europaea in 2007.{{cite web|url=http://www.ae-info.org/ae/Member/Eisner_David |title=Academy of Europe: Eisner David |publisher=Ae-info.org |access-date=30 April 2017}} He was elected to Honorary Fellowship of The Royal College of Physicians in 2010. In 2018 he received an honorary doctorate, Doctor Honoris Causa, from The University of Debrecen.{{Cite web|url=https://edu.unideb.hu/news.php?id=476|title=University of Debrecen -|last=születnek|first=www.WebDeb.hu – ahol a weblapok|website=edu.unideb.hu|access-date=15 June 2018}} and, in 2021 from The University of Szeged.{{Cite web|title=Szeged University, University Day 2021| date=13 November 2021 |url=https://u-szeged.hu/sztehirek/2021-november/diszdoktori-cimek?objectParentFolderId=19396|url-status=live|archive-url=https://web.archive.org/web/20211116134448/https://u-szeged.hu/sztehirek/2021-november/diszdoktori-cimek?objectParentFolderId=19396 |archive-date=16 November 2021 }} Prizes awarded to him include: The GL Brown{{cite web|url=http://www.physoc.org/gl-brown-prize-lecture |title=GL Brown Prize Lecture | Physiological Society |publisher=Physoc.org |date=29 May 2011 |access-date=30 April 2017}}{{cite web|url=https://www.youtube.com/watch?v=VXSJkq5Dk8o |title=Calcium in the heart: from physiology to disease – David Eisner (GL Brown Lecture 2014) |via=YouTube |date=16 May 2014 |access-date=30 April 2017}} and Annual Review Lecture{{cite journal | vauthors = Eisner DA | title = Ups and downs of calcium in the heart | journal = The Journal of Physiology | volume = 596 | issue = 1 | pages = 19–30 | date = January 2018 | pmid = 29071725 | pmc = 5746526 | doi = 10.1113/JP275130 }} of The Physiological Society; the Keith Reimer Lecture{{cite web|url=http://www.ishrworld.org/?page=PastAwardRecipients#Reimer |title=ISHR Hall of Fame |publisher=International Society for Heart Research |access-date=30 April 2017}}{{cite journal | vauthors = Eisner DA, Kashimura T, O'Neill SC, Venetucci LA, Trafford AW | title = What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? | journal = Journal of Molecular and Cellular Cardiology | volume = 46 | issue = 4 | pages = 474–81 | date = April 2009 | pmid = 19150449 | doi = 10.1016/j.yjmcc.2008.12.005 }} and the Peter Harris Distinguished Scientist Award of the International Society for Heart Research; the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology;{{Cite journal|last=escardio|date=25 October 2013|title=The Carmeliet-Coraboeuf-Weidmann Lecture – David Eisner|url=https://www.slideshare.net/escardio/eisner-ccw-lecture-for-website}} the Fabio Ruzzier Lecture of The Italian Physiological Society.{{Cite web|url=https://www.feps-sif2019.com/lectures/|title=Lectures|website=FEPS SIF 2019|access-date=25 June 2019}} He has also delivered the Burdon-Sanderson Lecture (Oxford) in 2013.{{Cite web|url=https://www.dpag.ox.ac.uk/about-us/john-burdon-sanderson-lecture|title=Sir John Burdon-Sanderson Prize Lecture Series – Physiology, Anatomy and Genetics|publisher=University of Oxford|access-date=26 February 2020|archive-date=18 February 2020|archive-url=https://web.archive.org/web/20200218073859/https://www.dpag.ox.ac.uk/about-us/john-burdon-sanderson-lecture|url-status=dead}}

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Category:British cardiologists

Category:Fellows of the Academy of Medical Sciences (United Kingdom)

Category:1955 births

Category:Living people

Category:Alumni of King's College, Cambridge

Category:People educated at Manchester Grammar School

Category:Fellows of the Royal College of Physicians

Category:British physiologists

Category:The Journal of Physiology editors

Category:Presidents of The Physiological Society