David A. Ferenbach

David Arthur Ferenbach was born and raised in Edinburgh, Scotland, the eldest of three brothers and one sister. He attended George Watson's College in Edinburgh and matriculated at the University of Edinburgh, graduating with a Bachelor of Medicine, Bachelor of Surgery (MBChB), alongside an intercalated Bachelor of Science with honours in Pathology.{{cite web |title=The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice |url=https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2787660 |accessdate=9 May 2025 |publisher=American Society of Nephrology}} Following medical school, he completed house officer rotations in Edinburgh. He then moved to Glasgow, working as a Senior House Officer on the Royal Infirmary medical rotation and later as an SHO3 in Renal Medicine at the Glasgow Royal and Western Infirmaries.

Ferenbach pursued his doctoral research in Nephrology at the University of Edinburgh under the supervision of Professor Jeremy Hughes and Dr David Kluth. His PhD was supported by a Clinical Training Fellowship from Kidney Research UK (2005–2008),{{cite journal |last1=Ferenbach |first1=D. A. |last2=Ramdas |first2=V. |last3=Spencer |first3=N. |last4=Marson |first4=L. |last5=Anegon |first5=I. |last6=Hughes |first6=J. |last7=Kluth |first7=D. C. |date=2010 |title=Macrophages Expressing Heme Oxygenase-1 Improve Renal ... |journal=Molecular Therapy : The Journal of the American Society of Gene Therapy |volume=18 |issue=9 |pages=1706–1713 |doi=10.1038/mt.2010.100 |pmc=2956932 |pmid=20551909}} followed by a Research Fellowship from Medical Research Scotland (2008–2009). He was appointed Clinical Lecturer in Nephrology at the University of Edinburgh in 2011. In 2013, he was awarded a Wellcome Trust Intermediate Clinical Fellowship, during which he conducted research at Harvard Medical School and Edinburgh.{{cite journal |last1=Ferenbach |first1=David A. |date=25 May 2016 |title=Kidney tubules: intertubular, vascular, and glomerular cross-talk |journal=Current Opinion in Nephrology and Hypertension |volume=25 |issue=3 |pages=194–202 |doi=10.1097/MNH.0000000000000218 |pmid=27023838|pmc=4845750 }} In 2022, he received an MRC Senior Clinical Fellowship to investigate senescent cell signalling pathways.{{cite web |title=Professor David Ferenbach |date=10 September 2024 |url=https://inflammation-research.ed.ac.uk/research/research-groups/professor-david-ferenbach |publisher=University of Edinburgh |accessdate=9 May 2025}} He was promoted to Personal Chair of Regenerative Nephrology at the University of Edinburgh in April 2023.{{cite web |title=David Ferenbach |url=https://www.research.ed.ac.uk/en/persons/david-ferenbach |publisher=University of Edinburgh |accessdate=9 May 2025}} He is also a fellow in the Royal College of Physicians of Edinburgh.

Ferenbach's research centres on the mechanisms of acute kidney injury, the role of macrophages in renal repair, the effects of ageing and cellular senescence on kidney disease progression, and the development of senescence‑targeted anti‑fibrotic therapies. As of 2025, he has authored over 37 peer‑reviewed articles and led multiple grants funded by the Medical Research Council, ARGENX BV, and Kidney Research UK. Ferenbach's work has been featured in outlets such as Medical Xpress{{cite web |date=31 May 2023 |title=Study shines light on cause of chronic kidney disease |url=https://medicalxpress.com/news/2023-05-chronic-kidney-disease.html |accessdate=9 May 2025 |publisher=}} and SciTechDaily.{{cite web |date=20 July 2023 |title=New Research Shines Light on Cause of Chronic Kidney Disease |url=https://scitechdaily.com/new-research-shines-light-on-cause-of-chronic-kidney-disease/ |accessdate=9 May 2025 |publisher=}}

• {{cite journal |last1=O'Sullivan |first1=Eoin D. |last2=Mylonas |first2=Katie J. |last3=Xin |first3=Cuiyan |last4=Baird |first4=David P. |last5=Carvalho |first5=Cyril |last6=Docherty |first6=Marie‑Helena |last7=Campbell |first7=Ross A. |last8=Matchett |first8=Kylie P. |last9=Waddell |first9=Scott H. |last10=Walker |first10=Alexander D. |title=Indian Hedgehog release from TNF‑activated renal epithelia drives local and remote organ fibrosis |journal=Science Translational Medicine |volume=15 |issue=698 |pages=eabn0736 |date=31 May 2023 |doi=10.1126/scitranslmed.abn0736 |pmid=37256934 |pmc=11977576 }}
• {{cite journal |last1=Ferreira-Gonzalez |first1=Sofia |last2=Man |first2=Tak Yung |last3=Esser |first3=Hannah |last4=Aird |first4=Rhona |last5=Kilpatrick |first5=Alastair M. |last6=Rodrigo‑Torres |first6=Daniel |last7=Younger |first7=Nicholas |last8=Campana |first8=Lara |last9=Gadd |first9=Victoria L. |last10=Dwyer |first10=Benjamin |title=Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage |journal=Science Translational Medicine |volume=14 |issue=674 |pages=eabj4375 |date=7 December 2022 |doi=10.1126/scitranslmed.abj4375 |pmid=36475903 |url=https://www.pure.ed.ac.uk/ws/files/312938681/abj4375_Combined_PDF_Sofia_Ferreira_Gonza.pdf }}
• {{cite journal |last1=O'Sullivan |first1=Eoin D. |last2=Mylonas |first2=Katie J. |last3=Bell |first3=Rachel |last4=Carvalho |first4=Cyril |last5=Baird |first5=David P. |last6=Campbell |first6=Ross A. |last7=Docherty |first7=Marie‑Helena |last8=Mylonas |first8=Hannah |title=Single‑cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis |journal=JCI Insight |volume=7 |issue=22 |pages=e154124 |date=22 November 2022 |doi=10.1172/jci.insight.154124 |pmid=36509292 |pmc=9746814 }}
• {{cite journal |last1=Campbell |first1=Ross A. |last2=Docherty |first2=Marie‑Helena |last3=Ferenbach |first3=David A. |last4=Mylonas |first4=Katie J. |title=The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis |journal=Frontiers in Immunology |volume=12 |page=700790 |date=1 June 2021 |doi=10.3389/fimmu.2021.700790 |doi-access=free |pmid=34220864 |pmc=8248495 }}

• [https://orcid.org/0000-0002-9202-1428 ORCID profile]
• [https://www.ed.ac.uk/inflammation-research/people/principal-investigators/dr-david-ferenbach University of Edinburgh profile]
• [https://uk.linkedin.com/in/david-ferenbach-455a2813 LinkedIn profile]

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Category:Living people

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