David Altshuler (physician)
{{short description|American geneticist}}
{{about|the physician and geneticist|the Judaic scholar of the same name|David Altshuler (curator)}}
{{Infobox scientist
| name = David Altshuler
| birth_name = David Matthew Altshuler
| image = David Altshuler Vertex Portrait.jpg
| image_size = 300px
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| birth_date = {{Birth date and age|1964|08|27}}
| birth_place = Ithaca, New York
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| workplaces = {{Plainlist|
| education = {{Plainlist|
| thesis_title = Endogenous retinal activities that influence the development of rod photoreceptors in vitro
| thesis_url = https://www.proquest.com/docview/304096852
| thesis_year = 1994
| doctoral_advisor = Connie Cepko
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| known_for = HapMap
awards = {{Plainlist|
- Curt Stern Award (2011){{Cite journal | last1 = Chakravarti | first1 = A. | author-link = Aravinda Chakravarti| title = 2011 Introduction to Curt Stern Award | doi = 10.1016/j.ajhg.2012.02.015 | journal = The American Journal of Human Genetics | volume = 90 | issue = 3 | pages = 405–406 | year = 2012 | pmid = 22405085 | pmc = 3309201}}{{Cite journal | last1 = Altshuler | first1 = D. | title = 2011 Curt Stern Award Address | doi = 10.1016/j.ajhg.2012.02.017 | journal = The American Journal of Human Genetics | volume = 90 | issue = 3 | pages = 407–409 | year = 2012 | pmid = 22405086 | pmc = 3309200}}
- Outstanding Scientific Achievement Award American Diabetes Association (2012){{citation needed|date=August 2014}}}}
| signature =
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| website = {{URL|http://www.vrtx.com/our-team/senior-management}}
| footnotes =
| spouse = Jill Suttenberg Altshuler
}}
David Matthew Altshuler (born August 27, 1964){{cite web |title=Altshuler, David, 1964- |url=https://id.loc.gov/authorities/names/n2010182548.html |website=id.loc.gov |access-date=January 7, 2021}} is a clinical endocrinologist and human geneticist. He is Executive Vice President, Global Research and Chief Scientific Officer at Vertex Pharmaceuticals.{{cite web|title=David Altshuler, M.D., Ph.D., Joins Vertex as Executive Vice President of Global Research and Chief Scientific Officer|url=http://investors.vrtx.com/releasedetail.cfm?ReleaseID=887657|website=Vertex|access-date=30 March 2015}} Prior to joining Vertex in 2014, he was at the Broad Institute of Harvard and MIT,{{cite web|url=http://www.broadinstitute.org/about/bios/bio-altshuler.html |title=David Altshuler | Broad Institute of MIT and Harvard |archive-date=2012-03-27 |archive-url=https://web.archive.org/web/20120327012941/http://www.broadinstitute.org/about/bios/bio-altshuler.html |url-status=dead }} and was a Professor of Genetics and Medicine at Harvard Medical School, and in the Department of Biology at Massachusetts Institute of Technology. He was also a faculty member in the Department of Molecular Biology, Center for Human Genetic Research, and the Diabetes Unit, all at Massachusetts General Hospital. He was one of four Founding Core Members of the Broad Institute, and served as the Institute's Deputy Director, Chief Academic Officer, and Director of the Program in Medical and Population Genetics.{{Scopus|id=7005798316}}{{Cite journal | pmid = 10973253| year = 2000| last1 = Altshuler| first1 = D| title = The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes| journal = Nature Genetics| volume = 26| issue = 1| pages = 76–80| last2 = Hirschhorn| first2 = J. N.| last3 = Klannemark| first3 = M| last4 = Lindgren| first4 = C. M.| last5 = Vohl| first5 = M. C.| last6 = Nemesh| first6 = J| last7 = Lane| first7 = C. R.| last8 = Schaffner| first8 = S. F.| last9 = Bolk| first9 = S| last10 = Brewer| first10 = C| last11 = Tuomi| first11 = T| last12 = Gaudet| first12 = D| last13 = Hudson| first13 = T. J.| last14 = Daly| first14 = M| last15 = Groop| first15 = L| last16 = Lander| first16 = E. S.| doi = 10.1038/79216| s2cid = 25842690}}
Education
Altshuler attended Commonwealth School in Boston, received his Bachelor of Science from Massachusetts Institute of Technology,{{cite web|url=http://alum.mit.edu/news/AlumniProfiles/Archive/altshuler |title=David Altshuler '86 | MIT Alumni Association's Infinite Connection |archive-date=2011-08-06 |archive-url=https://web.archive.org/web/20110806164707/http://alum.mit.edu/news/AlumniProfiles/Archive/altshuler |url-status=dead }} his Ph.D from Harvard University, and his M.D. from Harvard Medical School.{{cite web|url=http://genetics.med.harvard.edu/faculty/altshuler |title=David Altshuler, M.D., Ph.D. | HMS Department of Genetics |archive-date=2012-03-08 |archive-url=https://web.archive.org/web/20120308210843/http://genetics.med.harvard.edu/faculty/altshuler |url-status=dead }} He completed his internship, residency, and clinical fellowship training at Massachusetts General Hospital.
Research
Altshuler's academic research focused on human genetic variation and its application to disease,{{Cite journal | last1 = Altshuler | first1 = D. | last2 = Daly | first2 = M. J. | last3 = Lander | first3 = E. S. | author-link3 = Eric Lander| doi = 10.1126/science.1156409 | title = Genetic Mapping in Human Disease | journal = Science | volume = 322 | issue = 5903 | pages = 881–888 | year = 2008 | pmid = 18988837 | pmc =2694957 | bibcode = 2008Sci...322..881A }}{{Cite journal | last1 = Mootha | first1 = V. K. | last2 = Lindgren | first2 = C. M. | last3 = Eriksson | first3 = K. F. | last4 = Subramanian | first4 = A. | last5 = Sihag | first5 = S. | last6 = Lehar | first6 = J. | last7 = Puigserver | first7 = P. | last8 = Carlsson | first8 = E. | last9 = Ridderstråle | first9 = M. | last10 = Laurila | doi = 10.1038/ng1180 | first10 = E. | last11 = Houstis | first11 = N. | last12 = Daly | first12 = M. J. | last13 = Patterson | first13 = N. | last14 = Mesirov | first14 = J. P. | author14-link = Jill P. Mesirov| last15 = Golub | first15 = T. R. | last16 = Tamayo | first16 = P. | last17 = Spiegelman | first17 = B. | last18 = Lander | first18 = E. S. | last19 = Hirschhorn | first19 = J. N. | last20 = Altshuler | first20 = D. | last21 = Groop | first21 = L. C. | title = PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | journal = Nature Genetics | volume = 34 | issue = 3 | pages = 267–273 | year = 2003 | pmid = 12808457| s2cid = 13940856 }}{{Cite journal | last1 = Lander | first1 = E. S. | author-link1 = Eric Lander| last2 = Altshuler | first2 = M. | last3 = Ireland | first3 = D. | last4 = Sklar | first4 = J. | last5 = Ardlie | first5 = P. | last6 = Patil | first6 = K. | last7 = Shaw | first7 = N. | last8 = Lane | first8 = C. R. | last9 = Lim | first9 = E. P. | last10 = Kalyanaraman | first10 = N. | last11 = Nemesh | first11 = J. | last12 = Ziaugra | first12 = L. | last13 = Friedland | first13 = L. | last14 = Rolfe | first14 = A. | last15 = Warrington | first15 = J. | last16 = Lipshutz | first16 = R. | last17 = Daley | first17 = G. Q. | last18 = Lander | first18 = E. S. | title = Characterization of single-nucleotide polymorphisms in coding regions of human genes | journal = Nature Genetics | volume = 22 | issue = 3 | pages = 231–238 | doi = 10.1038/10290 | year = 1999 | pmid = 10391209 | s2cid = 195213008 }}{{Cite journal | last1 = De Bakker | first1 = P. I. W. | last2 = Yelensky | first2 = R. | last3 = Pe'Er | first3 = I. | last4 = Gabriel | first4 = S. B. | last5 = Daly | first5 = M. J. | last6 = Altshuler | first6 = D.| doi = 10.1038/ng1669 | title = Efficiency and power in genetic association studies | journal = Nature Genetics | volume = 37 | issue = 11 | pages = 1217–1223 | year = 2005 | pmid = 16244653| s2cid = 15464860 }} using information from the Human Genome Project.{{Cite journal | last1 = Gabriel | first1 = S. B. | last2 = Schaffner | first2 = S. F. | last3 = Nguyen | first3 = H. | last4 = Moore | first4 = J. M. | last5 = Roy | first5 = J. | last6 = Blumenstiel | first6 = B. | last7 = Higgins | first7 = J. | last8 = Defelice | first8 = M. | last9 = Lochner | first9 = A. | last10 = Faggart | first10 = M. | last11 = Liu-Cordero | first11 = S. N. | last12 = Rotimi | first12 = C. | last13 = Adeyemo | first13 = A. | last14 = Cooper | first14 = R. | last15 = Ward | first15 = R. | last16 = Lander | first16 = E. S. | last17 = Daly | first17 = M. J. | last18 = Altshuler | first18 = D. | title = The Structure of Haplotype Blocks in the Human Genome | doi = 10.1126/science.1069424 | journal = Science | volume = 296 | issue = 5576 | pages = 2225–2229 | year = 2002 | pmid = 12029063| bibcode = 2002Sci...296.2225G | s2cid = 10069634 | doi-access = free }} He has co-led the SNP Consortium, International HapMap Project,{{Cite journal
| last1 = Gibbs | first1 = R. A. | last2 = Belmont | first2 = J. W. | last3 = Hardenbol | first3 = P. | last4 = Willis | first4 = T. D. | last5 = Yu | first5 = F. | last6 = Yang | first6 = H. | last7 = Ch'Ang | first7 = L. Y. | last8 = Huang | first8 = W. | doi = 10.1038/nature02168
| last9 = Liu | first9 = B.
| last10 = Shen | first10 = Y.
| last11 = Tam | first11 = P. K. H.
| last12 = Tsui | first12 = L. C.
| last13 = Waye | first13 = M. M. Y.
| last14 = Wong | first14 = J. T. F.
| last15 = Zeng | first15 = C.
| last16 = Zhang | first16 = Q.
| last17 = Chee | first17 = M. S.
| last18 = Galver | first18 = L. M.
| last19 = Kruglyak | first19 = S.
| last20 = Murray | first20 = S. S.
| last21 = Oliphant | first21 = A. R.
| last22 = Montpetit | first22 = A.
| last23 = Hudson | first23 = T. J.
| last24 = Chagnon | first24 = F.
| last25 = Ferretti | first25 = V.
| last26 = Leboeuf | first26 = M.
| last27 = Phillips | first27 = M. S.
| last28 = Verner | first28 = A.
| last29 = Kwok | first29 = P. Y. | title = The International HapMap Project | journal = Nature | volume = 426 | issue = 6968 | pages = 789–796 | year = 2003 | pmid = 14685227 | bibcode = 2003Natur.426..789G
| url = https://deepblue.lib.umich.edu/bitstream/2027.42/62838/1/nature02168.pdf| hdl = 2027.42/62838
| s2cid = 4387110
| hdl-access = free }}{{Cite journal | last1 = Frazer | first1 = K. A. | last2 = Frazer | first2 = D. G. | last3 = Ballinger | first3 = D. R. | last4 = Cox | first4 = D. A. | last5 = Hinds | first5 = L. L. | last6 = Stuve | first6 = R. A. | last7 = Gibbs | first7 = J. W. | last8 = Belmont | first8 = A. | last9 = Boudreau | first9 = P. | last10 = Hardenbol | doi = 10.1038/nature06258 | first10 = S. M. | last11 = Leal | first11 = S. | last12 = Pasternak | first12 = D. A. | last13 = Wheeler | first13 = T. D. | last14 = Willis | first14 = F. | last15 = Yu | first15 = H. | last16 = Yang | first16 = C. | last17 = Zeng | first17 = Y. | last18 = Gao | first18 = H. | last19 = Hu | first19 = W. | last20 = Hu | first20 = C. | last21 = Li | first21 = W. | last22 = Lin | first22 = S. | last23 = Liu | first23 = H. | last24 = Pan | first24 = X. | last25 = Tang | first25 = J. | last26 = Wang | first26 = W. | last27 = Wang | first27 = J. | last28 = Yu | first28 = B. | last29 = Zhang | first29 = Q. | last30 = Zhang | first30 = H. | display-authors = 1 | title = A second generation human haplotype map of over 3.1 million SNPs | journal = Nature | volume = 449 | issue = 7164 | pages = 851–861 | year = 2007 | pmid = 17943122 | pmc =2689609 | bibcode = 2007Natur.449..851F }} and 1000 Genomes Project{{Cite journal | last1 = Gabriel | first1 = S. B. | last2 = Schaffner | first2 = S. F. | last3 = Nguyen | first3 = H. | last4 = Moore | first4 = J. M. | last5 = Roy | first5 = J. | last6 = Blumenstiel | first6 = B. | last7 = Higgins | first7 = J. | last8 = Defelice | first8 = M. | last9 = Lochner | first9 = A. | last10 = Faggart | first10 = M. | last11 = Liu-Cordero | first11 = S. N. | last12 = Rotimi | first12 = C. | last13 = Adeyemo | first13 = A. | last14 = Cooper | first14 = R. | last15 = Ward | first15 = R. | last16 = Lander | first16 = E. S. | last17 = Daly | first17 = M. J. | last18 = Altshuler | first18 = D. | title = The Structure of Haplotype Blocks in the Human Genome | doi = 10.1126/science.1069424 | journal = Science | volume = 296 | issue = 5576 | pages = 2225–2229 | year = 2002 | pmid = 12029063| bibcode = 2002Sci...296.2225G | s2cid = 10069634 | doi-access = free }}{{Cite journal | last1 = Sachidanandam | first1 = R. | last2 = Weissman | first2 = D. | last3 = Schmidt | first3 = S. C. | last4 = Kakol | first4 = J. M. | last5 = Stein | first5 = L. D. | author-link5 = Lincoln Stein| last6 = Marth | first6 = G. | last7 = Sherry | first7 = S. | last8 = Mullikin | first8 = J. C. | last9 = Mortimore | first9 = B. J. | last10 = Willey | doi = 10.1038/35057149 | first10 = D. L. | last11 = Hunt | first11 = S. E. | last12 = Cole | first12 = C. G. | last13 = Coggill | first13 = P. C. | last14 = Rice | first14 = C. M. | last15 = Ning | first15 = Z. | last16 = Rogers | first16 = J. | last17 = Bentley | first17 = D. R. | last18 = Kwok | first18 = P. Y. | last19 = Mardis | first19 = E. R. | last20 = Yeh | first20 = R. T. | last21 = Schultz | first21 = B. | last22 = Cook | first22 = L. | last23 = Davenport | first23 = R. | last24 = Dante | first24 = M. | last25 = Fulton | first25 = L. | last26 = Hillier | first26 = L. | last27 = Waterston | first27 = R. H. | last28 = McPherson | first28 = J. D. | last29 = Gilman | first29 = B. | last30 = Schaffner | first30 = S. | title = A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms | journal = Nature | volume = 409 | issue = 6822 | pages = 928–933 | year = 2001 | pmid = 11237013| bibcode = 2001Natur.409..928S | doi-access = free }}[https://scholar.google.co.uk/scholar?q=david+altshuler David Altshuler publications in Google Scholar] His research focused on the genetic basis of Type 2 Diabetes, and his laboratory contributed to mapping dozens of gene variants that are associated with risk of Type 2 Diabetes, lipid levels, myocardial infarction, rheumatoid arthritis, lupus, prostate cancer, and other disorders.
Awards and honors
Among his awards is election to the American Society for Clinical Investigation, the Association of American Physicians, and the Institute of Medicine. He is a member of the board of directors of the American Society of Human Genetics and was previously a member of the board of Vertex Pharmaceuticals. In 2011 he won the Curt Stern Award of the American Society of Human Genetics, and in 2012 the Outstanding Scientific Achievement Award of the American Diabetes Association. He is a member of the board of trustees of Becket Chimney Corners YMCA.
References
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Category:Commonwealth School alumni
Category:Harvard Medical School alumni
Category:Massachusetts Institute of Technology School of Science alumni