David C. Rubinsztein

{{Infobox scientist

| name = David Rubinsztein

| birth_name = David Chaim Rubinsztein

| image =

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| caption = David Rubinsztein in 2014

| alt =

| birth_date = {{birth year and age|1963}}

| birth_place =

| other_names =

| residence =

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| fields = Autophagy
Neurodegenerative diseases{{Google scholar id}}

| workplaces = University of Cambridge
Cambridge Institute for Medical Research
Cambridge Drug Discovery Institute

| known_for = autophagy and polyglutamine expansions

| alma_mater = University of Cape Town (MBChB, PhD)

| thesis_title = Monogenic hypercholesterolemia in South Africans: familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100

| thesis_url = http://www.worldcat.org/oclc/890418932

| thesis_year = 1993

| doctoral_advisor = Prof. D.R. van der Westhuyzen

| academic_advisors =

| awards = {{Plainlist|

Fellow of the Academy of Medical Sciences (2004){{Cite web | url=https://acmedsci.ac.uk/more/news/14-academy-fellows-elected-to-the-royal-society-in-2017 | title=14 Academy Fellows elected to the Royal Society in 2017 | the Academy of Medical Sciences}}
EMBO Member (2011)
Fellow of the Royal Society (2017)
Prix Roger de Spoelberch (2017)

}}

| website = {{Plainlist|

{{URL|cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/rubinsztein}}
{{URL|http://www.neuroscience.cam.ac.uk/directory/profile.php?dcr1000}}}}

}}

David Chaim Rubinsztein (born 1963) is the Deputy Director of the Cambridge Institute of Medical Research (CIMR),{{cite web|url=http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/rubinsztein.html|title=Professor David C. Rubinsztein|publisher=University of Cambridge}}{{Dead link|date=July 2019 |bot=InternetArchiveBot |fix-attempted=yes }} Professor of Molecular Neurogenetics at the University of Cambridge{{Cite web|url=http://www.neuroscience.cam.ac.uk/directory/profile.php?dcr1000|title=Professor David Rubinsztein :: Cambridge Neuroscience|website=www.neuroscience.cam.ac.uk|access-date=2018-01-08}} and a UK Dementia Research Institute Professor.

Education

Rubinsztein completed his Bachelor of Medicine, Bachelor of Surgery (MB ChB) in 1986 and PhD in 1993 in the Medical Research Council/University of Cape Town Unit for the Cell Biology of Atherosclerosis. In 1993 he went to Cambridge as a senior registrar in Genetic Pathology.[http://f1000.com/prime/thefaculty/member/7810398887369674 F1000 Prime Faculty Member]

Career

In 1997, Rubinsztein acquired his Certificate of Completion of Specialist Training at the University of Cambridge. He was appointed to a Personal Readership at the University of Cambridge in 2003. In 2005, he was promoted to Professor of Molecular Neurogenetics at the University of Cambridge (personal chair). He has been an author on more than 400 scientific papers,[https://www.researchgate.net/profile/David_Rubinsztein/publications/ Research Gate] and was ranked as the 4th most cited European author from 2007 to 2013 in cell biology.{{Cite web |url=http://ki.se/sites/default/files/cellbiologystats.pdf |title=Publication analysis 2007–2013, Cell Biology |access-date=26 November 2015 |archive-date=4 March 2016 |archive-url=https://web.archive.org/web/20160304050615/http://ki.se/sites/default/files/cellbiologystats.pdf |url-status=dead }} Rubinsztein has been invited to give talks at major international conferences, including Gordon Research Conferences and Keystone Symposia.{{cite web|url=http://www.csap.cam.ac.uk/network/david-rubinsztein/|title=Centre for Science and Policy|publisher=University of Cambridge}}{{cite journal|last1=Renna|first1=M.|last2=Jimenez-Sanchez|first2=M.|last3=Sarkar|first3=S.|last4=Rubinsztein|first4=D. C.|title=Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases|journal=Journal of Biological Chemistry|volume=285|issue=15|year=2010|pages=11061–11067|issn=0021-9258|doi=10.1074/jbc.R109.072181|pmid=20147746|pmc=2856980|doi-access=free }} {{open access}}{{cite journal|url=http://www.jbc.org/content/285/15/11061/suppl/DC1|journal=The Journal of Biological Chemistry|title=Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases|year=2010 |pmid=20147746 |last1=Renna |first1=M. |last2=Jimenez-Sanchez |first2=M. |last3=Sarkar |first3=S. |last4=Rubinsztein |first4=D. C. |volume=285 |issue=15 |pages=11061–11067 |doi=10.1074/jbc.R109.072181 |pmc=2856980 |doi-access=free }}

Research

Rubinsztein has made major contributions to the field of neurodegeneration with his laboratory's discovery that autophagy regulates the levels of intracytoplasmic aggregate-prone proteins that cause many neurodegenerative diseases, including Huntington's, Parkinson's and Alzheimer's disease.{{Cite journal | doi = 10.1038/nrd3802| pmid = 22935804| title = Autophagy modulation as a potential therapeutic target for diverse diseases| journal = Nature Reviews Drug Discovery| volume = 11| issue = 9| pages = 709–730| year = 2012| last1 = Rubinsztein | first1 = D. C. | pmc = 3518431}}{{Cite journal | doi = 10.1038/ng1362| title = Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease| journal = Nature Genetics| volume = 36| issue = 6| pages = 585–595 | year = 2004| last1 = Ravikumar | first1 = B. | last2 = Rubinsztein | first2 = D. C. | pmid=15146184| doi-access = free}}{{Cite web|url=http://archive.sciencewatch.com/ana/st/autophagy/08julSTAutoRubi/|title=David Rubinsztein Interview - Special Topic of Autophagy - ScienceWatch.com|last=Analytics|first=Clarivate|website=archive.sciencewatch.com|access-date=2018-01-08}}{{Cite journal | doi = 10.1038/nm1242| title = Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice| journal =Nature Medicine| volume = 11| issue = 6| pages = 672–677 | year = 2005| last1 = Davies | first1 = J. E. | last2 = Rubinsztein | first2 = D. C. | pmid=15864313| s2cid = 13190118}}{{Cite journal | doi = 10.1038/nchembio883| title = Small molecules enhance autophagy and reduce toxicity in Huntington's disease models| journal = Nature Chemical Biology| volume = 3| issue = 6| pages = 331–338 | year = 2007| last1 = Sarkar | first1 = S. | last2 = Rubinsztein | first2 = D. C. | pmid=17486044 | pmc=2635561}} His lab has found that autophagy may be inhibited in various neurodegenerative diseases{{Cite journal | doi = 10.1083/jcb.201003122 | pmid = 20855506| title = α-Synuclein impairs macroautophagy: implications for Parkinson's disease| journal = The Journal of Cell Biology| volume = 190| issue = 6| pages = 1023–1037| year = 2010 | last1 = Winslow | first1 = A. R. | last2 = Rubinsztein | first2 = D. C.| pmc = 3101586}} and has elucidated the pathological consequences of autophagy compromise.{{Cite journal | doi = 10.1038/ng1591| title = Dynein mutations impair autophagic clearance of aggregate-prone proteins| journal = Nature Genetics| volume = 37| issue = 7| pages = 771–776| year = 2005| last1 = Ravikumar | first1 = B. | last2 = Rubinsztein | first2 = D. C. | pmid=15980862| s2cid = 7628772}} In addition his research has advanced the basic understanding of autophagy, identifying the plasma membrane as a source of autophagosome membrane{{Cite journal | doi = 10.1038/ncb2078 | title = Plasma membrane contributes to the formation of pre-autophagosomal structures| journal = Nature Cell Biology| volume = 12| issue = 8| pages = 747–757| year = 2010 | last1 = Ravikumar | first1 = B. | last2 = Rubinsztein | first2 = D. C. | pmid=20639872 | pmc=2923063}} and characterising early events in autophagosome biogenesis,.{{Cite journal | doi = 10.1016/j.cell.2011.06.023| title = Autophagosome precursor maturation requires homotypic fusion| journal = Cell| volume = 146| issue = 2| pages = 303–317| year = 2011 | last1 = Moreau | first1 = K. | last2 = Rubinsztein | first2 = D. C. | pmid=21784250 | pmc=3171170}}{{Cite journal | doi = 10.1016/j.cell.2013.08.044| title = Diverse autophagosome membrane sources coalesce in recycling endosomes| journal = Cell| volume = 154| issue = 6| pages = 1285–1299| year = 2013 | last1 = Puri | first1 = C. | last2 = Rubinsztein | first2 = D. C. | pmid=24034251 | pmc=3791395}}{{Cite journal | doi = 10.1016/j.molcel.2014.12.007| pmid = 25578879| pmc = 4306530| title = PI(5)P regulates autophagosome biogenesis| journal = Molecular Cell| volume = 57| issue = 2| pages = 219–234| year = 2015 | last1 = Vicinanza | first1 = M. | last2 = Rubinsztein | first2 = D. C.}} Furthermore, he studied how lysosomal positioning regulates autophagy.{{Cite journal | doi = 10.1038/ncb2204| pmid = 21394080| pmc = 3071334| title = Lysosomal positioning coordinates cellular nutrient responses| journal = Nature Cell Biology| volume = 13| issue = 4| pages = 453–460| year = 2011 | last1 = Korolchuk | first1 = V. I. | last2 = Rubinsztein | first2 = D. C.}} His goal is to understand the links between these diseases and autophagy. He is currently focused on understanding how to induce autophagy in vivo to remove toxic proteins and avoid the development of neurodegenerative disease{{Cite news|url=http://www.sens.org/videos/autophagy-guardian-against-neurodegeneration-part-2-david-rubinsztein/|title=Autophagy, a guardian against neurodegeneration - Part 2 - David Rubinsztein|date=2013-11-27|work=SENS Research Foundation|access-date=2018-01-08|language=en|archive-date=8 December 2015|archive-url=https://web.archive.org/web/20151208133422/http://www.sens.org/videos/autophagy-guardian-against-neurodegeneration-part-2-david-rubinsztein/|url-status=dead}}

=Honours and awards=

Rubinsztein has won numerous awards including:

1997 Glaxo-Wellcome Fellowship{{citation needed|date=May 2017}}
2001 Medical Research Council (MRC) Programme grant, Wellcome Trust Senior Clinical Fellowship
2004 Elected a Fellow of the Academy of Medical Sciences (FMedSci){{cite web|url=http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-david-rubinsztein|website=acmedsci.ac.uk|publisher=Academy of Medical Sciences|location=London|author=Anon|year=2004|title=Professor David Rubinsztein FMedSci|access-date=26 November 2015|archive-date=4 March 2016|archive-url=https://web.archive.org/web/20160304053326/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-david-rubinsztein/|url-status=dead}}
2005 Professor of Molecular Neurogenetics, University of Cambridge
2006 MRC Programme grant, Wellcome Trust Senior Clinical Fellowship{{Cite web |url=http://www.wellcome.ac.uk/Funding/Biomedical-science/Funded-projects/Awards-made/Wellcome-Fellows/WTD003260.htm/ |title=Wellcome Trust |access-date=26 November 2015 |archive-date=2 October 2015 |archive-url=https://web.archive.org/web/20151002023748/http://www.wellcome.ac.uk/Funding/Biomedical-science/Funded-projects/Awards-made/Wellcome-Fellows/WTD003260.htm |url-status=dead }}
2007 Graham Bull Prize for Clinical Science by the Royal College of Physicians{{cite web|url=http://www.nature.com/cdd/about/biographies.html/ |title=Editor biographies|website=Nature}}
2011 Member of the European Molecular Biology Organization (EMBO){{cite web|url=http://people.embo.org/profile/david-c-rubinsztein|website=people.embo.org|title=EMBO people: David C. Rubinsztein}}
2012 Wellcome Trust Principal Fellowship{{Cite web | url=https://wellcome.ac.uk/funding/people-and-projects/grant-funding-data |title = Funded People and Projects - Grant Funding | Wellcome}}
2013 Deputy Director of Cambridge Institute for Medical Research, University of Cambridge
2014 Thomson Reuters Highly Cited Researcher for 2014 in the categories Biology and Biochemistry and Molecular Biology and Genetics[http://highlycited.com/ Thomson Reuters]
2015 Thomson Reuters Highly Cited Researcher for 2015 in the categories Biology and Biochemistry
2015 Academic Lead of ARUK Cambridge Drug Discovery Institute
2015 4th highest cited cell biologist in Europe and Israel for articles published between 2007 and 2013{{Cite web | url=http://www.labtimes.org/labtimes/ranking/2015_05/index.lasso | title=Labtimes: Publication Statistics: Cell Biology | access-date=12 April 2016 | archive-date=29 July 2017 | archive-url=https://web.archive.org/web/20170729050236/http://www.labtimes.org/labtimes/ranking/2015_05/index.lasso | url-status=dead }}
2016 Awarded Thudichum Medal from Biochemical Society for 2017{{cite web|url=http://www.biochemistry.org/Awards/2017Winners.aspx|publisher=biochemistry.org|title=2017 Award Winners|access-date=12 April 2016|archive-date=4 June 2016|archive-url=https://web.archive.org/web/20160604165124/http://www.biochemistry.org/Awards/2017Winners.aspx|url-status=dead}}
2017 Elected a Fellow of the Royal Society{{cite web|url=https://royalsociety.org/people/david-rubinsztein-13418/|title=Professor David Rubinsztein FRS|publisher=royalsociety.org|location=London|author=Anon|year=2017}}
2017 UK Dementia Research Institute Professor
2018 Awarded Prix Roger de Spoelberch for 2017
2018 Clarivate Analytics Highly Cited Researcher for 2018{{Cite web | url=https://hcr.clarivate.com | title=Highly Cited Researchers - the Most Influential Scientific Minds}}
2019 Clarivate Analytics Highly Cited Researcher for 2019{{Cite web | url=https://recognition.webofsciencegroup.com/awards/highly-cited/2019/ | title=Highly Cited Researchers}}
2020 Awarded Goudie Medal and lecture from Pathological Society of Great Britain & Ireland{{cite web |url= https://www.pathsoc.org/files/meetings/2020WM/WM2020MainProg14.01.20.pdf/ |title= Main Programme 212th Scientific Meeting of the Pathological Society of Great Britain & Ireland }}{{Dead link|date=October 2022 |bot=InternetArchiveBot |fix-attempted=yes }}
2020 Clarivate Analytics Highly Cited Researcher 2020{{Cite web | url=https://recognition.webofscience.com/awards/highly-cited/2020/ | title=Highly Cited Researchers| date=13 November 2024}}
2021 Clarivate Analytics Highly Cited Researcher 2021{{Cite web | url=https://recognition.webofscience.com/awards/highly-cited/2021// | title=Highly Cited Researchers | access-date=24 November 2021 | archive-date=24 November 2021 | archive-url=https://web.archive.org/web/20211124080303/https://recognition.webofscience.com/awards/highly-cited/2021/ | url-status=dead }}
2022 Elected member of Academia Europaea, The Academy of Europe{{Cite web | url=https://www.ae-info.org/ae/Member/Rubinsztein_David// | title= Member > Rubinsztein David}}
2022 Clarivate Analytics Highly Cited Researcher 2022{{Cite web | url=https://clarivate.com/highly-cited-researchers/| title=Highly Cited Researchers| date=13 November 2024}}
2023 Clarivate Analytics Highly Cited Researcher 2023{{Cite web | url=https://clarivate.com/highly-cited-researchers/?action=clv_hcr_members_filter&clv-paged=1&clv-category=&clv-institution=&clv-region=&clv-name=Rubinsztein| title=Highly Cited Researchers| date=13 November 2024}}
2024 American Academy of Neurology Movement Disorders Research Award{{Cite web | url=https://www.aan.com/research/scientific-research-award-recipients//| title=Scientific Research Award Recipients}}
2024 Clarivate Analytics Highly Cited Researcher 2024{{Cite web | url=https://clarivate.com/highly-cited-researchers/?action=clv_hcr_members_filter&clv-paged=1&clv-category=&clv-institution=&clv-region=&clv-name=Rubinsztein| title=Highly Cited Researchers| date=13 November 2024}}

References

Category:1963 births

Category:Wellcome Trust Principal Research Fellows

Category:University of Cape Town alumni

Category:Fellows of the Royal Society

Category:Fellows of the Academy of Medical Sciences (United Kingdom)

Category:Members of the European Molecular Biology Organization

Category:Members of Academia Europaea

Category:British medical researchers

Category:British neuroscientists

Category:British geneticists

Category:Living people