David Eisenberg

{{short description|American biochemist and biophysicist (born 1939)}}

{{for|the American physician|David M. Eisenberg}}

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{{Like resume|date=September 2021}}

{{Prose|date=September 2021}}

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{{Infobox scientist

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| image = David Eisenberg - journal.pcbi.1003116.g001.png

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| caption = David Eisenberg

| birth_date = {{Birth date and age|1939|03|15}}

| birth_place = Chicago, Illinois, US

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| fields = Proteins{{Cite journal | last1 = Eisenberg | first1 = D. | author-link1= David Eisenberg| last2 = McLachlan | first2 = A. D. | doi = 10.1038/319199a0 | title = Solvation energy in protein folding and binding | journal = Nature | volume = 319 | issue = 6050 | pages = 199–203 | year = 1986 | pmid = 3945310| bibcode = 1986Natur.319..199E | s2cid = 21867582 }}
Amyloid{{Cite journal

| last1 = Balbirnie | first1 = M.

| last2 = Grothe | first2 = R.

| last3 = Eisenberg | first3 = D. S.

| doi = 10.1073/pnas.041617698

| title = An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid

| journal = Proceedings of the National Academy of Sciences

| volume = 98

| issue = 5

| pages = 2375–2380

| year = 2001

| pmid = 11226247

| pmc =30146

| bibcode = 2001PNAS...98.2375B

| doi-access = free

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Structural biology{{Cite journal

| last1 = Lüthy | first1 = R.

| last2 = Bowie | first2 = J. U.

| last3 = Eisenberg | first3 = D.

| doi = 10.1038/356083a0

| title = Assessment of protein models with three-dimensional profiles

| journal = Nature

| volume = 356

| issue = 6364

| pages = 83–85

| year = 1992

| pmid = 1538787

| bibcode = 1992Natur.356...83L

| s2cid = 4369151

}}{{Cite journal

| doi = 10.1126/science.3133767

| last1 = Chapman | first1 = M. S.

| last2 = Suh | first2 = S. W.

| last3 = Curmi | first3 = P. M.

| last4 = Cascio | first4 = D.

| last5 = Smith | first5 = W. W.

| last6 = Eisenberg | first6 = D. S.

| title = Tertiary structure of plant RuBisCO: Domains and their contacts

| journal = Science

| volume = 241

| issue = 4861

| pages = 71–74

| year = 1988

| pmid = 3133767

| bibcode = 1988Sci...241...71C }}{{GoogleScholar|DLXzRi8AAAAJ}}

| workplaces = Howard Hughes Medical Institute
University of Oxford
University of California, Los Angeles
Harvard University
California Institute of Technology
Princeton University

| alma_mater = Harvard University (undergraduate)
The Queen's College, Oxford (postgraduate)

| thesis_title = Some problems in the electronic structure of molecules

| thesis_url = http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?docId=oxfaleph019444285

| thesis_year = 1965

| doctoral_advisor = Charles Coulson{{citation needed|date=June 2013}}

| academic_advisors =

| doctoral_students =

| notable_students = {{Plainlist|

  • Charlotte Deane{{Cite web|url=http://eisenberglab.mbi.ucla.edu/?page_id=87|title = Former Lab Members | David Eisenberg's Lab}} (postdoctoral fellow)
  • Michael Gribskov{{Cite web|url=http://eisenberglab.mbi.ucla.edu/?page_id=87|title = Former Lab Members | David Eisenberg's Lab}} (postdoctoral fellow)

}}

| known_for =

| awards = Harvey Prize (2008)
ISCB Senior Scientist Award (2013){{Cite journal | last1 = Fogg | first1 = C. N. | last2 = Kovats | first2 = D. E. | doi = 10.1371/journal.pcbi.1003116 | title = International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award | journal = PLOS Computational Biology | volume = 9 | issue = 6 | pages = e1003116 | year = 2013 | pmc =3681620 | bibcode = 2013PLSCB...9E3116F | doi-access = free }}

| signature =

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| website = {{Plainlist|

  • {{URL|http://eisenberglab.mbi.ucla.edu}}
  • {{URL|http://www.hhmi.org/research/investigators/eisenberg_bio.html}}

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David S. Eisenberg (born 15 March 1939{{citation needed|date=June 2013}}) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. He has been a professor at the University of California, Los Angeles since the early 1970s and was director of the UCLA-DOE Institute for Genomics & Proteomics, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.[http://www.hhmi.org/research/investigators/eisenberg_bio.html HHMI profile of David Eisenberg][http://www.doe-mbi.ucla.edu/People/Eisenberg/ The Eisenberg research lab at UCLA][http://www.doe-mbi.ucla.edu UCLA-DOE Institute for Genomics & Proteomics]{{YouTube|S7U-nXAWtvs|David Eisenberg’s speech during the Harvey Prize ceremony}}{{cite book |author1=Eisenberg, David |author2=Kauzmann, Walter |title=The structure and properties of water |publisher=Clarendon Press |location=Oxford |year=2005 |isbn=0-19-857026-0 }}{{AcademicSearch|926759}}{{Scopus|id=19434183500}}

Education

Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965{{cite thesis |degree=PhD |first=David J.|last=Eisenberg |title=Some problems in the electronic structure of molecules |publisher=University of Oxford |date=1965 |url=http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?docId=oxfaleph019444285|author-link=David Eisenberg}} for research supervised by Charles Coulson.

Research

Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.{{Cite journal

| last1 = Salwinski | first1 = L.

| last2 = Miller | first2 = C. S.

| last3 = Smith | first3 = A. J.

| last4 = Pettit | first4 = F. K.

| last5 = Bowie | first5 = J. U.

| last6 = Eisenberg | first6 = D.

| author-link6 = David Eisenberg

| title = The Database of Interacting Proteins: 2004 update

| doi = 10.1093/nar/gkh086

| journal = Nucleic Acids Research

| volume = 32

| issue = 90001

| pages = D449–D451

| year = 2004

| pmid = 14681454

| pmc =308820

}}

Career

Awards

He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.[https://harveypz.net.technion.ac.il/harvey-prize-laureates/ Harvey Prize Award]

  • 1961 - L.J. Henderson Prize
  • 1958-1960 - Harvard College Honorary Scholarships
  • 1961-1964 - Rhodes Scholarship
  • 1972-1977 - USPHS Career Development Award
  • 1975 - UCLA Distinguished Teaching Award
  • 1982 - McCoy Award of the UCLA Department of Chemistry and Biochemistry for innovative research
  • 1989 - Member, National Academy of Sciences (Biophysics & Computational Biology section){{Cite web|title=David S. Eisenberg|url=http://www.nasonline.org/member-directory/members/7987.html|access-date=2021-09-14|website=www.nasonline.org}}
  • 1992 - Pierce Award of the Immunotoxin Society
  • 1996 - Protein Society Stein & Moore Award
  • 1998 - American Chemical Society Repligen Corporation Award in Chemistry of Biological Processes
  • 2000 - Investigator, Howard Hughes Medical Institute
  • 2000 - Amgen Award of the Protein Society
  • 2001 - Fellow, American Association for the Advancement of Science
  • 2003 - Member, American Philosophical Society{{Cite web|title=APS Member History|url=https://search.amphilsoc.org/memhist/search?creator=David+S.+Eisenberg&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced|access-date=2021-09-14|website=search.amphilsoc.org}}
  • 2004 - UCLA Glenn T. Seaborg Medal{{Cite web |title=UCLA Glenn T. Seaborg Symposium - Previous Recipients |url=https://www.seaborg.ucla.edu/previous_recipients.html |access-date=2024-01-05 |website=www.seaborg.ucla.edu}}
  • 2005 - Harvard University's Westheimer Medal
  • 2008 - ACS Nobel Laureate Signature Award for Graduate Education in Chemistry (as preceptor, student was Rebecca Anne Nelson)
  • 2013 - ISCB (International Society for Computational Biology) Senior Scientist Award
  • 2020 - Passano Award[https://www.passanofoundation.org/services Passano Award 2020]

References