David Keays

Keays studied Science and Law at the University of Queensland, graduating with a BSc majoring in neuroscience and LLB (Hons) in 1998. He received his honours degree in science from the University of Melbourne in 2001 with a thesis describing the isolation and discovery of a novel conotoxin with analgesic activity from the cone shell Conus victoriae.{{Cite journal |doi = 10.1021/bi034043e|title = A Novel α-Conotoxin Identified by Gene Sequencing is Active in Suppressing the Vascular Response to Selective Stimulation of Sensory Nerves in Vivo†|journal = Biochemistry|volume = 42|issue = 22|pages = 6904–6911|year = 2003|last1 = Sandall|first1 = D. W.|last2 = Satkunanathan|first2 = N.|last3 = Keays|first3 = D. A.|last4 = Polidano|first4 = M. A.|last5 = Liping|first5 = X.|last6 = Pham|first6 = V.|last7 = Down|first7 = J. G.|last8 = Khalil|first8 = Z.|last9 = Livett|first9 = B. G.|last10 = Gayler|first10 = K. R.|pmid = 12779345}} He practiced law as a criminal prosecutor with the Office of Public Prosecutions (OPP) and was admitted to the Supreme Court of Victoria as a Barrister and Solicitor in 2002.

In 2002, Keays was appointed as Christopher Welch Scholar by the University of Oxford and joined the lab of Jonathan Flint at the Wellcome Trust Centre for Human Genetics to conduct research for a DPhil degree. During his degree he identified an ENU-induced mutation of α-1 tubulin that resulted in abnormal hippocampal layering in mice. He went on to show that mutations in the human homolog (TUBA1A), cause cortical brain malformations in humans.{{Cite journal |doi = 10.1016/j.cell.2006.12.017 |pmc=1885944 |title = Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans|journal = Cell|volume = 128|pages = 45–57|year = 2007|last1 = Keays|first1 = David A.|last2 = Tian|first2 = Guoling|last3 = Poirier|first3 = Karine|last4 = Huang|first4 = Guo-Jen|last5 = Siebold|first5 = Christian|last6 = Cleak|first6 = James|last7 = Oliver|first7 = Peter L.|last8 = Fray|first8 = Martin|last9 = Harvey|first9 = Robert J.|last10 = Molnár|first10 = Zoltán|last11 = Piñon|first11 = Maria C.|last12 = Dear|first12 = Neil|last13 = Valdar|first13 = William|last14 = Brown|first14 = Steve D.M.|last15 = Davies|first15 = Kay E.|last16 = Rawlins|first16 = J. Nicholas P.|last17 = Cowan|first17 = Nicholas J.|last18 = Nolan|first18 = Patrick|last19 = Chelly|first19 = Jamel|last20 = Flint|first20 = Jonathan|issue=1 |pmid=17218254 }} He was awarded a DPhil in 2006 and became a Wellcome Trust OXION research fellow at St Anne's College, Oxford to continue his research on the molecular processes that drive neuronal migration during neuronal development.

When Keays started his own research group at the IMP in Vienna as an Independent Fellow in 2008, he decided to start a second research branch, investigating the molecular, cellular and neuroanatomical basis of magnetoreception. Using the pigeon as their model organism, his lab was able to show that iron-rich structures in the beaks of pigeons were not part of magnetosensitive neurons but iron deposits in macrophages.{{Cite journal |doi = 10.1038/nature11046|title = Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons|journal = Nature|volume = 484|issue = 7394|pages = 367–370|year = 2012|last1 = Treiber|first1 = Christoph Daniel|last2 = Salzer|first2 = Marion Claudia|last3 = Riegler|first3 = Johannes|last4 = Edelman|first4 = Nathaniel|last5 = Sugar|first5 = Cristina|last6 = Breuss|first6 = Martin|last7 = Pichler|first7 = Paul|last8 = Cadiou|first8 = Herve|last9 = Saunders|first9 = Martin|last10 = Lythgoe|first10 = Mark|last11 = Shaw|first11 = Jeremy|last12 = Keays|first12 = David Anthony|pmid = 22495303|bibcode = 2012Natur.484..367T|s2cid = 205228624}} His work has continued to challenge the magnetite-based theory of magnetoreception,Edelman, NB., Fritz, T., Nimpf, S., Pichler, P., Lauwers, M., Hickman, RW., Papadaki-Anastasopoulou, A., Ushakova, L., Heuser, T., Resch, GP., Saunders, M., Shaw, JA., Keays, DA. (2015). No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening. Proc Natl Acad Sci U S A. 112(1):262-7 but advanced electromagnetic induction as an alternative mechanism that allows animals to detect magnetic fields. He has identified a highly sensitive electroceptor (CaV1.3) within the pigeon inner ear, that would enable the detection of minute electric currents generated by movement through the Earth's magnetic field.Nimpf S, Nordmann GC, Kagerbauer D, Malkemper EP, Landler L, Papadaki-Anastasopoulou A, Ushakova L, Wenninger-Weinzierl A, Novatchkova M, Vincent P, Lendl T, Colombini M, Mason MJ, Keays DA. A putative mechanism for magnetoreception by electromagnetic induction in the pigeon inner ear. Curr Biol. 2019 Dec 2;29(23):4052-4059

In parallel Keays has continued his research on the microtubule cytoskeleton and neurodevelopment. Employing mice and cerebral organoids as model systems his laboratory has shown that mutations in the beta tubulin TUBB5 cause microcephaly,Breuss, M., Heng, JI., Poirier, K., Tian, G., Jaglin, XH., Qu, Z., Braun, A., Gstrein, T., Ngo, L., Haas, M., Bahi-Buisson, N., Moutard, ML., Passemard, S., Verloes, A., Gressens, P., Xie, Y., Robson, KJ., Rani, DS., Thangaraj, K., Clausen, T., Chelly, J., Cowan, NJ., Keays, DA. (2012). Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell Rep. 2(6):1554-62 that variants in the microtubule associated protein MAST1 result in mega corpus callosum syndrome,Tripathy R, van Dijk T, van Bon B, Gstrein T, Bahi-Buisson N, Paciorkowski A, Pagnamenta A, Taylor J, Terrone G, Vitiello G, D’Amico A, Del Giudice E, Brunetti-Pierri N, Reymond A, Voisin N, Bernstein JA, Farrelly E, Pierson T, Kini U, Leonard T, Mirzaa G, Baas F, Chelly J, Keays DA. Mutations in MAST1 cause mega corpus callosum syndrome and cortical malformations. Neuron. 2018 Dec 19;100(6):1354-1368. and that mutations in PIK3r4 are associated with neurodevelopmental disorders.Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. (2018). Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nature Neuroscience. Feb;21(2):207-217

Awards and Honours

Keays has been awarded the Amgen Australian Award in Biotechnology (2000), the Verne Chapman Young Investigator Award (2004), the Peter Beaconsfield Prize in Biosciences (2014), an EMBO Young Investigator (YIP) Award (2013), and the Otto Loewi Prize in Neuroscience (2015). In addition Keays has received a FWF START Award and an ERC Starting Grant in 2014, as well as an ERC Consolidator grant in 2019.{{Cite web | url=http://keayslab.org/people/ | title=People | keays lab}} In 2014 Keays was admitted to the Austrian Academy of Sciences as a Young Member.

David Attenborough refers to research findings from the Keays lab in Natural Curiosities Episode 2, Series 4{{Cite web | url=https://www.bbc.co.uk/programmes/b09tmnhk |title = BBC Two - David Attenborough's Natural Curiosities, Series 4, Finding the Way}} and the group's work has been featured in articles in the Economist,{{Cite news|url=https://www.economist.com/science-and-technology/2013/07/13/columbarian-columbuses|title = Columbarian Columbuses|newspaper = The Economist|date = 13 July 2013}} the New Yorker,{{Cite magazine|url=https://www.newyorker.com/tech/elements/how-do-animals-keep-from-getting-lost|title = How do Animals Keep from Getting Lost?| magazine=The New Yorker |date = 28 May 2016}} BBC Radio 4,{{Cite web|url=https://www.bbc.co.uk/programmes/b03mhw27|title = BBC Radio 4 - Show Me the Way to Go Home}} as well as NBC News {{Cite web|url=https://www.nbcnews.com/science/iron-found-bird-brains-could-be-key-migration-6C9803906?franchiseSlug=sciencemain|title = Iron found in bird brains could be key to migration| website=NBC News | date=6 May 2013 }} and ABC Australia.{{Cite news|url=https://www.abc.net.au/news/2012-04-12/pigeon-riddle-flies-in-face-of-science/3944894|title = Pigeon riddle has scientists in a flap| newspaper=ABC News |date = 11 April 2012}}

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Category:1976 births

Category:University of Queensland alumni

Category:University of Melbourne alumni

Category:Alumni of Merton College, Oxford

Category:Australian expatriates in Austria

Category:Australian expatriates in England

Category:Living people