David Siderovski
{{Short description|American pharmacologist}}
{{Primary sources|date=June 2024}}
{{Infobox scientist
| name = David Siderovski
| image = David Siderovski on June 4th 2019.jpg
| image_size =
| alt =
| caption =
| fields = Biochemistry
Pharmacology
Neuroscience
Medical education
| workplaces = Amgen Research Institute
University of North Carolina at Chapel Hill
West Virginia University
University of North Texas Health Science Center
| education = {{unbulleted list | Queen's University (BSc) | University of Toronto (PhD) }}
| thesis_title = Human Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat)
| thesis_url = http://www.collectionscanada.gc.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ27724.pdf
| thesis_year = 1997
| doctoral_advisor = Tak Wah Mak
| academic_advisors = Alfred G. Gilman
Robert J. Lefkowitz
| prizes = ASPET's John J. Abel Award in 2004
}}
David Siderovski is a North American pharmacologist.{{Cite web|url=https://www.aspet.org/docs/default-source/uploadedfiles/knowledge_center/abel-number.pdf|title=Abel Numbers|date=May 30, 2019|website=ASPET.org|access-date=November 21, 2019}} Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center.{{cite news |last1=Joy |first1=William |title=New COVID-19 treatment has helped dozens in China, UNTHSC researchers say |url=https://www.wfaa.com/article/news/health/coronavirus/new-covid-19-treatment-has-helped-dozens-in-china-unthsc-researchers-say/287-22675c63-0cac-4837-843f-c7a0748afdc5 |work=wfaa.com |publisher=WFAA (ABC Channel 8 Dallas, TX) |date=12 March 2020}} From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine.{{Cite news|url=https://www.chronicle.com/article/One-University-Takes-On-the/241325|title=One University Takes On the Opioid Crisis|last=Mcmurtrie|first=Beth|date=2017-10-01|work=The Chronicle of Higher Education|access-date=2019-11-21|language=en-US|issn=0009-5982}}
Education
Siderovski attended Earl Haig Secondary School in North York, Ontario,{{cite news |last1=Gotlieb |first1=Risha |title=School caters to bright kids |url=https://www.proquest.com/docview/1370727936/ |access-date=27 December 2021 |work=The Toronto Star |issue=Page NY5 |publisher=Torstar Syndication Services, a Division of Toronto Star Newspapers Limited |date=9 Sep 1993 |language=en}} graduating in 1985.{{cite news |last1=Little |first1=James |title=Two students who had 98.5 averages are both dubbed Metro's top students |url=https://www.proquest.com/docview/1400913014 |access-date=27 December 2021 |work=The Toronto Star |publisher=Torstar Syndication Services, a Division of Toronto Star Newspapers Limited |date=5 July 1985|id={{ProQuest|1400913014}} }} In 1989, Siderovski graduated with a BSc from Queen's University in Kingston, Ontario.{{cite web|title=Prince of Wales Prizes|url=http://www.queensu.ca/studentawards/automatic-awards-open-all-students|website=Automatic Awards Open to All Upper Year Students|publisher=Queen's University|access-date=11 August 2015|archive-url=https://web.archive.org/web/20150924121248/http://www.queensu.ca/studentawards/automatic-awards-open-all-students|archive-date=24 September 2015|url-status=dead}}
Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto. He successfully defended his PhD thesis in November 1997.{{cite book |author=Siderovski, David Peter |title=Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat): Random mutagenesis and interaction with PKR |year=1997 |publisher=University of Toronto |url=http://www.collectionscanada.gc.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ27724.pdf |access-date=2015-08-04}} He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor.{{cite web|title=Methods of modulating T-cell activation WO 1997041438 A1|url=https://patents.google.com/patent/WO1997041438A1?oq=Siderovski|access-date=9 August 2015}}{{cite web|title=Apoptosis-inducing factor CA 2352467 A1|url=https://patents.google.com/patent/CA2352467A1/en?oq=Siderovski|access-date=9 August 2015}}{{cite web|title=Apoptosis-inducing factor CA 2352467 C|url=https://patents.google.com/patent/CA2352467C/en?oq=Siderovski|access-date=9 August 2015}}
Career
After completing his industrial postdoctoral position at the Amgen Research Institute in 1998,{{Cite web|url=http://www.the-scientist.com/?articles.view/articleNo/24053/title/Can-You-Go-Home-Again-/|title=Can You Go Home Again? {{!}} The Scientist Magazine|website=The Scientist|access-date=2016-06-09}} Siderovski joined the faculty at the University of North Carolina at Chapel Hill as an assistant professor of pharmacology.{{cite news |last1=Lang |first1=Leslie |title=UNC's Siderovski wins pharmacology award |url=https://www.eurekalert.org/news-releases/819735 |access-date=28 December 2021 |work=EurekAlert! |date=25 March 2004 |language=en}} His earliest publications discuss the RGS protein superfamily,{{cite journal |last1=Roush |first1=Wade |title=Regulating G Protein Signaling |journal=Science |date=23 February 1996 |volume=271 |issue=5252 |pages=1056–1058 |doi= 10.1126/science.271.5252.1056|pmid=8599078 |bibcode=1996Sci...271.1056R |s2cid=83216123 }}{{cite journal |vauthors = Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP | title = Molecular cloning and expression analysis of rat Rgs12 and Rgs14 | journal = Biochem Biophys Res Commun | volume = 233 | issue = 3 | pages = 770–7 | date = April 1997 | pmid = 9168931 | doi = 10.1006/bbrc.1997.6537}}{{cite journal |vauthors=Snow BE, Antonio L, Suggs S, Siderovski DP | title = Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene | journal = Gene | volume = 206 | issue = 2 | pages = 247–53 | date = January 1998 | pmid = 9469939 | doi =10.1016/s0378-1119(97)00593-3}}{{cite journal |vauthors=Siderovski DP, Strockbine B, Behe CI | title = Whither goest the RGS proteins? | journal = Crit Rev Biochem Mol Biol | volume = 34 | issue = 4 | pages = 215–51 | pmid = 10517644 | doi =10.1080/10409239991209273 | year=1999}} and determinations of their varied protein structures{{cite journal |last1=Davis |first1=Molly |title=Picture-perfect Proteins |journal=Endeavors |date=1 May 2007 |url=https://endeavors.unc.edu/spr2007/siderovski.php}}{{cite journal |vauthors=Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17749–55 | date = July 1998 | pmid = 9651375 | doi =10.1074/jbc.273.28.17749| doi-access = free }}{{cite journal |vauthors = Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP | title = A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits | journal = Proceedings of the National Academy of Sciences of the United States of America| volume = 95 | issue = 22 | pages = 13307–12 | date = October 1998 | pmid = 9789084 | pmc = 23793| doi = 10.1073/pnas.95.22.13307| bibcode = 1998PNAS...9513307S | doi-access = free }} and cellular functions.{{cite journal |vauthors=Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP | title = Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity | journal = J Neurosci | volume = 18 | issue = 18 | pages = 7178–88 | date = September 1998 | pmid = 9736641 | pmc = 6793237| doi =10.1523/JNEUROSCI.18-18-07178.1998|display-authors=etal}}{{better source needed|reason=no independent sourcing|date=December 2021}}
In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics.{{cite journal |title=ASPET AWARD WINNERS FOR 2004 |journal=The Pharmacologist |date=March 2004 |volume=46 |issue=1 |page=3 |url=https://www.aspet.org/docs/default-source/news-files/the-pharmacologist/journal_search/v46n1_3_04.pdf?sfvrsn=aeff8bd2_0 |access-date=27 December 2021}}{{cite news |last1=Lang |first1=Leslie |title=UNC's Siderovski wins pharmacology award |url=https://www.eurekalert.org/news-releases/819735 |access-date=28 December 2021 |work=EurekAlert! |date=25 March 2004 |language=en}}{{better source needed|reason=no independent sourcing|date=December 2021}}
From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program.{{cite web|title=Leadership |url=http://www.med.unc.edu/mdphd/fps/leadership |website=UNC MD-PhD Program (circa March 24, 2012) |publisher=Internet Archive Wayback Machine |access-date=12 August 2015 |url-status=dead |archive-url=https://web.archive.org/web/20120324031923/http://www.med.unc.edu/mdphd/fps/leadership |archive-date=March 24, 2012 }} In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program.{{cite web|title=Siderovski Chosen to Oversee M.D./PH.D. Scholars Program|url=http://medicine.hsc.wvu.edu/news/story?headline=siderovski-chosen-to-oversee-m-d-ph-d-scholars-program|website=School of Medicine > Home > News > Story| date=11 August 2014 |publisher=WVU School of Medicine|access-date=13 August 2015}} Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012.{{Cite web|url=https://apps.asbmb.org/jbcboard/Default.aspx?SearchPhrase=siderovski|title=JBC Editorial Board}}
References
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Category:Queen's University at Kingston alumni
Category:American pharmacologists
Category:West Virginia University faculty