DayQuil

Selecting a product should depend on the specific symptom presentation of the user. Products should be selected with active ingredients limited only to those symptoms, thereby reducing the risk of over treatment with medications that the user is not showing symptoms for. Additionally, careful note should be taken when purchasing multiple over-the-counter cold and flu medicines because many products may contain the same active ingredient. The potential for overdose increases when consumers are unaware of the duplication of active ingredients in these medicines.{{cite journal | author = Yin HS | title = Use of active ingredient information for low socioeconomic status parents' decision-making regarding cough and cold medications: role of health literacy | journal = Academic Pediatrics | year = 2013 |display-authors=etal | pmid=23680341 | doi=10.1016/j.acap.2013.01.004 | volume=13 | issue = 3 | pmc=3747773 | pages=229–35}}

There are conflicting studies showing the effectiveness of over-the-counter cold medicine in reducing cold and flu symptoms. A number of studies have found acetaminophen (alone and in combination) to be effective{{cite journal | url = http://www.clinicaltherapeutics.com/article/S0149-2918(06)00216-5/abstract | author = Burnett I | title = Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: a double-blind, placebo-controlled study in adult patients with acute sore throat| journal = Clinical Therapeutics | year = 2006 | volume = 28 | issue = 9 | pages = 1273–1278 | doi = 10.1016/j.clinthera.2006.09.009 | pmid = 17062300 |display-authors=etal}}{{cite journal | author = Mizoguchi H | title = Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms | journal = International Journal of Clinical Pharmacology and Therapeutics | year = 2007 |display-authors=etal | pmid=17474541 | volume=45 | issue = 4 | pages=230–6 | doi=10.5414/cpp45230}} and a safe treatment for common cold symptoms such as sore throat and body aches. In contrast, a systematic review including 26 randomized controlled trials compared the use of over-the-counter cough medicines with no treatment in children and adults exhibiting cough in the ambulatory or outpatient setting.{{cite journal | url = http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001831.pub4/abstract;jsessionid=37913D4FD7536094559F574F940421A1.f02t02 | author = Smith SM | editor-first1 = Susan M. | editor-last1 = Smith | title = Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory setting | journal = Cochrane Database of Systematic Reviews | year = 2012 |display-authors=etal | doi=10.1002/14651858.CD001831.pub4 | pmid=22895922 | volume=8 | issue = 8 | page=CD001831}}{{Update inline|reason=Updated version https://www.ncbi.nlm.nih.gov/pubmed/25420096|date=August 2017}} Among the studies, there was conflicting evidence of the effectiveness of cough medicines containing an antitussive, antihistamine or decongestant in providing better cough resolution outcomes versus no treatment.

Abuse and recreational use of dextromethorphan have been reported with over-the-counter preparations and can cause euphoric and dissociative effects at higher than recommended doses.{{cite journal | author = Bryner JK | title = Dextromethorphan abuse in adolescence: an increasing trend | journal = Archives of Pediatrics and Adolescent Medicine | year = 2006 |display-authors=etal | pmid=17146018 | doi=10.1001/archpedi.160.12.1217 | volume=160 | issue = 12 | pmc=2257867 | pages=1217–22}}

There is a risk of severe liver damage with the concurrent use of acetaminophen products and excessive alcohol use (≥3 alcoholic drinks/day depending on body weight). Acetaminophen is an active ingredient of many over-the-counter single ingredient products (e.g. to treat headache), multiple ingredient combination products as well as prescription-only medications written by a physician. Each formulation also varies per dose. When purchasing over-the-counter medications, avoid purchasing multiple products with acetaminophen ingredients. The suggested maximum daily intake of acetaminophen is limited to <4 grams (4,000 mg) daily in adults or <2.6g (2,600 mg) daily in children <12 years of age to reduce the risk of liver damage.{{cite journal | url = http://www.ccjm.org/content/77/1/19.long | author = Schilling A | title = Acetaminophen: Old drug, new warnings | journal = Cleveland Clinic Journal of Medicine | year = 2010 | volume = 77 | issue = 1 | pages = 19–27 | doi = 10.3949/ccjm.77a.09084 | pmid = 20048026 | s2cid = 17368757 |display-authors=etal| doi-access = free }}{{cite web | url = http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee/UCM164897.pdf | author = FDA | title = Acetaminophen Overdose and Liver Injury - Background and Options for Reducing Injury | website = Food and Drug Administration }}

Those prescribed monoamine oxidase inhibitor (MAO-i) should avoid the use of DayQuil products containing dextromethorphan within 2 weeks to avoid risks of Serotonin Syndrome.{{cite journal | author = Gillman PK | title = Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. | journal = British Journal of Anaesthesia | year = 2005 | pmid=16051647 | doi=10.1093/bja/aei210 | volume=95 | issue = 4 | pages=434–41| doi-access = free }}

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Category:Vicks brands

Category:Products introduced in 1974