DeAndre Hopkins

As an infant, Hopkins was given the nickname Nuk by his mother because he frequently chewed through NUK pacifiers. It is pronounced "nuke" (although the pacifier brand is pronounced "nook").{{cite web |title=The incredible survival story of DeAndre Hopkins and his mom |url=https://www.espn.com/espn/feature/story/_/id/27793196/the-incredible-survival-story-deandre-hopkins-mom |website=ESPN |date=2019-10-16 |archive-url=https://web.archive.org/web/20210805223100/https://www.espn.com/espn/feature/story/_/id/27793196/the-incredible-survival-story-deandre-hopkins-mom |archive-date=2021-08-05 |url-status=live |last1=Kimes |first1=Mina |author-link=Mina Kimes |access-date=August 5, 2021}}{{cite web |title=OTWS: DeAndre Hopkins on OTAs, Houston, "Nuk" |url=https://www.houstontexans.com/video/otws-deandre-hopkins-on-otas-houston-nuk-10257363 |website=Houston Texans |date=2013-06-01 |archive-url=https://web.archive.org/web/20210805223059/https://www.houstontexans.com/video/otws-deandre-hopkins-on-otas-houston-nuk-10257363 |archive-date=2021-08-05 |url-status=live |access-date=August 5, 2021}}{{Cite web |date=February 15, 2015 |title=NUK Knows |url=https://www.youtube.com/watch?v=RXkKrf09bXI&t=7s |url-status=live |archive-url=https://web.archive.org/web/20210805223059/https://www.youtube.com/watch?v=RXkKrf09bXI&t=7s |archive-date=August 5, 2021 |access-date=August 5, 2021 |website=YouTube |publisher=NUK}}

Hopkins attended D. W. Daniel High School in Central, South Carolina, where he played football, basketball, and ran track and field for the Lions athletic teams.{{Cite web |last=Keepfer |first=Scott |date=July 22, 2017 |title=Former Clemson star receiver catches his breath at home |url=https://www.greenvilleonline.com/story/sports/college/clemson/2017/07/22/former-clemson-star-receiver-catches-his-breath-home/501701001/ |url-status=live |archive-url=https://web.archive.org/web/20230122051259/https://www.greenvilleonline.com/story/sports/college/clemson/2017/07/22/former-clemson-star-receiver-catches-his-breath-home/501701001/ |archive-date=January 22, 2023 |access-date=March 25, 2018 |work=The Greenville News}} During his high school football career, Hopkins had 57 receptions for 1,266 yards and 18 touchdowns on offense and 28 interceptions and five touchdowns on defense.{{Cite web |last=Wilson |first=Aaron |date=December 1, 2018 |title=Hands down, Texans wide receiver DeAndre Hopkins one of the NFL's best |url=https://www.houstonchronicle.com/sports/texans/article/Hands-down-Texans-wide-receiver-D-Andre-13437084.php |url-status=live |archive-url=https://web.archive.org/web/20190422135533/https://www.houstonchronicle.com/sports/texans/article/Hands-down-Texans-wide-receiver-D-Andre-13437084.php |archive-date=April 22, 2019 |access-date=January 30, 2019 |work=Houston Chronicle}} While on the basketball team, he played as a shooting guard and point guard, scoring 1,453 career points.{{cite web |title=DeAndre Hopkins' (Central SC) High School Basketball Stats |url=http://www.maxpreps.com/athlete/deandre-hopkins/pQEIAfTrEeKZ5AAmVebBJg/gendersport/basketball-stats.htm |website=MaxPreps |archive-url=https://web.archive.org/web/20140527214935/http://www.maxpreps.com/athlete/deandre-hopkins/pQEIAfTrEeKZ5AAmVebBJg/gendersport/basketball-stats.htm |archive-date=2014-05-27 |url-status=live |publisher=CBS Sports |access-date=May 26, 2014}} His senior season, 2009–10, the Lions won their third South Carolina State Championship,{{Cite web |title=DeAndre Hopkins Biography – Clemson Tigers Official Athletic Site |url=http://www.clemsontigers.com/ViewArticle.dbml?ATCLID=205529373 |url-status=dead |archive-url=https://web.archive.org/web/20170824175337/http://www.clemsontigers.com/ViewArticle.dbml?ATCLID=205529373 |archive-date=August 24, 2017 |access-date=May 26, 2014 |website=Clemson Tigers Athletics}} and Hopkins was named the Independent Mail's player of the year.{{Cite web |title=Videos: All-Area boys basketball – Anderson, SC |url=http://www.independentmail.com/videos/detail/all-area-boys-basketball/ |url-status=dead |archive-url=https://web.archive.org/web/20140528020822/http://www.independentmail.com/videos/detail/all-area-boys-basketball/ |archive-date=May 28, 2014 |access-date=May 26, 2014 |work=Anderson Independent Mail |publisher=Scripps Interactive Newspapers Group}} He was rated as the 12th best wide receiver in the nation and the State of South Carolina. He received various rankings by reputable sports organizations, ESPN ranked him the 29th best athlete. He earned an All-State first-team from the state and The Charlotte Observer.{{Cite web |date=September 7, 2019 |title=DeAndre Hopkins Biography Facts, Childhood, Career, Net Worth, Life |url=https://sportytell.com/american-football/deandre-hopkins-biography-facts-childhood-career-net-worth-life/ |url-status=live |archive-url=https://web.archive.org/web/20210513213822/https://sportytell.com/american-football/deandre-hopkins-biography-facts-childhood-career-net-worth-life/ |archive-date=May 13, 2021 |access-date=May 13, 2021 |work=SportyTell}}

Hopkins enrolled in Clemson University, where he played for the Clemson Tigers football team from 2010 to 2012 under head coach Dabo Swinney.{{Cite web |date=December 17, 2015 |title=Swinney Says That DeAndre Hopkins Was His Most Competitive Player |url=https://houston.cbslocal.com/2015/12/17/swinney-says-that-deandre-hopkins-was-his-most-competitive-player/ |url-status=dead |archive-url=https://web.archive.org/web/20151226014906/https://houston.cbslocal.com/2015/12/17/swinney-says-that-deandre-hopkins-was-his-most-competitive-player/ |archive-date=December 26, 2015 |access-date=October 11, 2018 |work=CBS – Houston}}

Hopkins immediately became a contributor to the Clemson offense as a freshman in their 6–7 season.{{Cite web |title=2010 Clemson Tigers Stats |url=https://www.sports-reference.com/cfb/schools/clemson/2010.html |url-status=live |archive-url=https://web.archive.org/web/20220628021931/https://www.sports-reference.com/cfb/schools/clemson/2010.html |archive-date=June 28, 2022 |access-date=June 28, 2022 |website=Sports Reference |language=en}}{{Cite web |title=2010 Clemson Tigers Schedule and Results |url=https://www.sports-reference.com/cfb/schools/clemson/2010-schedule.html |url-status=live |archive-url=https://web.archive.org/web/20220628021931/https://www.sports-reference.com/cfb/schools/clemson/2010-schedule.html |archive-date=June 28, 2022 |access-date=June 28, 2022 |work=Sports Reference}} Hopkins started his collegiate career with two receptions for 23 receiving yards in a 35–10 victory over North Texas on September 24.{{Cite web |title=North Texas at Clemson Box Score, September 4, 2010 |url=https://www.sports-reference.com/cfb/boxscores/2010-09-04-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225103015/https://www.sports-reference.com/cfb/boxscores/2010-09-04-clemson.html |archive-date=February 25, 2019 |access-date=February 24, 2019 |work=Sports Reference}} The next week, against Presbyterian, he scored his first collegiate receiving touchdown on a nine-yard reception from Tajh Boyd in the 58–21 victory.{{Cite web |title=Presbyterian at Clemson Box Score, September 11, 2010 |url=https://www.sports-reference.com/cfb/boxscores/2010-09-11-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225044805/https://www.sports-reference.com/cfb/boxscores/2010-09-11-clemson.html |archive-date=February 25, 2019 |access-date=February 24, 2019 |work=Sports Reference}} On November 13, in a road 16–13 loss to Florida State, he had eight receptions for 106 receiving yards.{{Cite web |title=Clemson at Florida State Box Score, November 13, 2010 |url=https://www.sports-reference.com/cfb/boxscores/2010-11-13-florida-state.html |url-status=live |archive-url=https://web.archive.org/web/20190225044831/https://www.sports-reference.com/cfb/boxscores/2010-11-13-florida-state.html |archive-date=February 25, 2019 |access-date=February 24, 2019 |work=Sports Reference}} In the final game of the regular season, the Palmetto Bowl against rival South Carolina, he had seven receptions for 124 receiving yards and a receiving touchdown in the 29–7 loss.{{Cite web |title=South Carolina at Clemson Box Score, November 27, 2010 |url=https://www.sports-reference.com/cfb/boxscores/2010-11-27-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225044750/https://www.sports-reference.com/cfb/boxscores/2010-11-27-clemson.html |archive-date=February 25, 2019 |access-date=February 24, 2019 |work=Sports Reference}} In the 2010 Meineke Car Care Bowl against South Florida, he had nine receptions for 105 receiving yards in the 31–26 loss to close out his freshman season.{{Cite web |title=Meineke Car Care Bowl – South Florida vs Clemson Box Score, December 31, 2010 |url=https://www.sports-reference.com/cfb/boxscores/2010-12-31-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225103019/https://www.sports-reference.com/cfb/boxscores/2010-12-31-clemson.html |archive-date=February 25, 2019 |access-date=February 24, 2019 |work=Sports Reference}} Hopkins was Clemson's leading receiver with 52 receptions for 637 receiving yards and four receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2010 Game Log |url=https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2010/ |url-status=live |archive-url=https://web.archive.org/web/20180325233141/https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2010/ |archive-date=March 25, 2018 |access-date=March 25, 2018 |work=Sports Reference}} In addition, he played basketball after his freshman season.{{Cite web |last=Sawchik |first=Travis |date=December 28, 2010 |title=Hopkins to join Tigers basketball team next week |url=http://www.heraldonline.com/latest-news/article12268616.html |url-status=live |archive-url=https://web.archive.org/web/20181012053932/https://www.heraldonline.com/latest-news/article12268616.html |archive-date=October 12, 2018 |access-date=February 16, 2020 |work=Herald Online}} He played in seven games in the 2010–11 season for the Tigers basketball team.{{Cite web |title=DeAndre Hopkins 2010–11 Game Log |url=https://www.sports-reference.com/cbb/players/deandre-hopkins-1/gamelog/2011/ |url-status=live |archive-url=https://web.archive.org/web/20210206192923/https://www.sports-reference.com/cbb/players/deandre-hopkins-1/gamelog/2011/ |archive-date=February 6, 2021 |access-date=February 2, 2021 |website=College Basketball at Sports-Reference.com}}

Clemson took a major step forward in Hopkins's sophomore year, finishing with a 10–4 mark.{{Cite web |title=2011 Clemson Tigers Schedule and Results |url=https://www.sports-reference.com/cfb/schools/clemson/2011-schedule.html |url-status=live |archive-url=https://web.archive.org/web/20220628021931/https://www.sports-reference.com/cfb/schools/clemson/2011-schedule.html |archive-date=June 28, 2022 |access-date=June 28, 2022 |work=Sports Reference}} Hopkins started the 2011 season with nine receptions for 108 receiving yards and a receiving touchdown in two games combined against Troy and Wofford.{{Cite web |title=Troy at Clemson Box Score, September 3, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-09-03-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20201030220855/https://www.sports-reference.com/cfb/boxscores/2011-09-03-clemson.html |archive-date=October 30, 2020 |access-date=May 1, 2020 |work=Sports Reference}}{{Cite web |title=Wofford at Clemson Box Score, September 10, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-09-10-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20211129140247/https://www.sports-reference.com/cfb/boxscores/2011-09-10-clemson.html |archive-date=November 29, 2021 |access-date=May 1, 2020 |work=Sports Reference}} Against Auburn on September 17, Hopkins had seven receptions for 83 receiving yards and a receiving touchdown in the 38–24 victory.{{Cite web |title=Auburn at Clemson Box Score, September 17, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-09-17-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225044841/https://www.sports-reference.com/cfb/boxscores/2011-09-17-clemson.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} On October 22, against North Carolina, he had nine receptions for 157 receiving yards and a receiving touchdown in the 59–38 victory.{{Cite web |title=North Carolina at Clemson Box Score, October 22, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-10-22-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225102959/https://www.sports-reference.com/cfb/boxscores/2011-10-22-clemson.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} Nearly a month later, against NC State, he had five receptions for 124 receiving yards in the 37–13 loss.{{Cite web |title=Clemson at North Carolina State Box Score, November 19, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-11-19-north-carolina-state.html |url-status=live |archive-url=https://web.archive.org/web/20190225103038/https://www.sports-reference.com/cfb/boxscores/2011-11-19-north-carolina-state.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} In the ACC Championship against Virginia Tech, he had seven receptions for 92 receiving yards in the 38–10 victory.{{Cite web |title=Virginia Tech vs Clemson Box Score, December 3, 2011 |url=https://www.sports-reference.com/cfb/boxscores/2011-12-03-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225044750/https://www.sports-reference.com/cfb/boxscores/2011-12-03-clemson.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} In the 2012 Orange Bowl, he had 10 receptions for 107 receiving yards and a receiving touchdown in the historic 70–33 loss to West Virginia.{{Cite web |title=Orange Bowl – West Virginia vs Clemson Box Score, January 4, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-01-04-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20181006000922/https://www.sports-reference.com/cfb/boxscores/2012-01-04-clemson.html |archive-date=October 6, 2018 |access-date=February 25, 2019 |work=Sports Reference}}{{Cite web |title=West Virginia drubs Clemson 70–33 in Orange Bowl |url=https://www.nfl.com/news/west-virginia-drubs-clemson-70-33-in-orange-bowl-09000d5d825ba11a |url-status=live |archive-url=https://web.archive.org/web/20201018045412/https://www.nfl.com/news/west-virginia-drubs-clemson-70-33-in-orange-bowl-09000d5d825ba11a |archive-date=October 18, 2020 |access-date=May 1, 2020 |website=NFL.com}} As a sophomore in 2011, he had 72 receptions for 978 receiving yards and five receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2011 Game Log |url=https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2011/ |url-status=live |archive-url=https://web.archive.org/web/20180325232659/https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2011/ |archive-date=March 25, 2018 |access-date=March 25, 2018 |work=Sports Reference}} He finished second on the team in the major receiving categories to Sammy Watkins.{{Cite web |title=2011 Clemson Tigers Stats |url=https://www.sports-reference.com/cfb/schools/clemson/2011.html |url-status=live |archive-url=https://web.archive.org/web/20201031163732/https://www.sports-reference.com/cfb/schools/clemson/2011.html |archive-date=October 31, 2020 |access-date=May 1, 2020 |work=Sports Reference}}

In his junior year, Hopkins helped lead the Tigers to their first 11-win season since 1981.{{Cite web |title=Clemson Tigers Football Record By Year |url=https://www.sports-reference.com/cfb/schools/clemson/index.html |url-status=live |archive-url=https://web.archive.org/web/20220628021935/https://www.sports-reference.com/cfb/schools/clemson/index.html |archive-date=June 28, 2022 |access-date=June 28, 2022 |work=Sports Reference}} Hopkins started the 2012 season off strong with 13 receptions for 119 receiving yards and a receiving touchdown in a 26–19 win over Auburn in the Chick-fil-A Kickoff Game. With Clemson trailing in the fourth quarter, Hopkins had the go-ahead score.{{Cite web |title=Clemson vs Auburn Box Score, September 1, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-09-01-auburn.html |url-status=live |archive-url=https://web.archive.org/web/20190225103153/https://www.sports-reference.com/cfb/boxscores/2012-09-01-auburn.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} One week later, against Ball State, he had six receptions for 105 receiving yards and three receiving touchdowns in a 52–27 victory.{{Cite web |title=Ball State at Clemson Box Score, September 8, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-09-08-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190412125415/https://www.sports-reference.com/cfb/boxscores/2012-09-08-clemson.html |archive-date=April 12, 2019 |access-date=February 25, 2019 |work=Sports Reference}} Hopkins three touchdowns all came in the second quarter, setting a new school record for touchdowns in a quarter. Dating back to the prior season, this gave Hopkins three consecutive games with 100 receiving yards, tying a school record.{{Cite web |title=Clemson Tigers 2020 Football Media Guide |url=https://data.clemsontigers.com/pdf/football/2020-21/MediaGuide.pdf |url-status=live |archive-url=https://web.archive.org/web/20210202202020/https://data.clemsontigers.com/pdf/football/2020-21/MediaGuide.pdf |archive-date=February 2, 2021 |access-date=February 2, 2021 |work=Clemson Tigers Athletics}} On September 29, against Boston College, had had 11 receptions for 197 receiving yards and a receiving touchdown in the 45–31 victory.{{Cite web |title=Clemson at Boston College Box Score, September 29, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-09-29-boston-college.html |url-status=live |archive-url=https://web.archive.org/web/20190225103243/https://www.sports-reference.com/cfb/boxscores/2012-09-29-boston-college.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} In the following game, he had seven receptions for 173 receiving yards and two receiving touchdowns against Georgia Tech in a 47–31 victory.{{Cite web |title=Georgia Tech at Clemson Box Score, October 6, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-10-06-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190225103141/https://www.sports-reference.com/cfb/boxscores/2012-10-06-clemson.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} On November 3, in a game at Duke, he had four receptions for 128 receiving yards and three receiving touchdowns in the 56–20 victory.{{Cite web |title=Clemson at Duke Box Score, November 3, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-11-03-duke.html |url-status=live |archive-url=https://web.archive.org/web/20190225103251/https://www.sports-reference.com/cfb/boxscores/2012-11-03-duke.html |archive-date=February 25, 2019 |access-date=February 25, 2019 |work=Sports Reference}} Like his previous three-touchdown game against Ball State, Hopkins recorded all three touchdowns in one quarter, with this performance being the first quarter. He closed out the regular season with one receiving touchdown in each of the last three games against Maryland, North Carolina State, and South Carolina.{{Cite web |title=Maryland at Clemson Box Score, November 10, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-11-10-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20200111154617/https://www.sports-reference.com/cfb/boxscores/2012-11-10-clemson.html |archive-date=January 11, 2020 |access-date=May 1, 2020 |work=Sports Reference}}{{Cite web |title=North Carolina State at Clemson Box Score, November 17, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-11-17-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20190327195134/https://www.sports-reference.com/cfb/boxscores/2012-11-17-clemson.html |archive-date=March 27, 2019 |access-date=May 1, 2020 |work=Sports Reference}}{{Cite web |title=South Carolina at Clemson Box Score, November 24, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-11-24-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20201012180447/https://www.sports-reference.com/cfb/boxscores/2012-11-24-clemson.html |archive-date=October 12, 2020 |access-date=May 1, 2020 |work=Sports Reference}} In the 2012 Chick-fil-A Bowl against LSU, he had 13 receptions for 191 receiving yards and two receiving touchdowns in the 25–24 victory. Hopkins's touchdown came with under three minutes remaining to put Clemson down 2. Clemson eventually won the game on 37-yard field goal from Chandler Catanzaro.{{Cite web |title=Chick-fil-A Bowl – LSU vs Clemson Box Score, December 31, 2012 |url=https://www.sports-reference.com/cfb/boxscores/2012-12-31-clemson.html |url-status=live |archive-url=https://web.archive.org/web/20201007200906/https://www.sports-reference.com/cfb/boxscores/2012-12-31-clemson.html |archive-date=October 7, 2020 |access-date=February 25, 2019 |work=Sports Reference}} In his junior season in 2012, Hopkins had one of the best receiving seasons in ACC history, with a conference-best 1,405 yards on 82 catches and a school-record 18 touchdowns earning First-team All-Conference honors.{{cite web |title=DeAndre Hopkins |url=http://www.cbssports.com/nfl/draft/players/1737078/deandre-hopkins |website=CBS Sports |archive-url=https://web.archive.org/web/20130117200849/http://www.cbssports.com/nfl/draft/players/1737078/deandre-hopkins |archive-date=2013-01-17 |url-status=live}}{{Cite web |title=2012 Atlantic Coast Conference Leaders |url=https://www.sports-reference.com/cfb/conferences/acc/2012-leaders.html |url-status=live |archive-url=https://web.archive.org/web/20180325235101/https://www.sports-reference.com/cfb/conferences/acc/2012-leaders.html |archive-date=March 25, 2018 |access-date=March 25, 2018 |work=Sports Reference}}{{Cite web |title=DeAndre Hopkins 2012 Game Log |url=https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2012/ |url-status=live |archive-url=https://web.archive.org/web/20180325235109/https://www.sports-reference.com/cfb/players/deandre-hopkins-1/gamelog/2012/ |archive-date=March 25, 2018 |access-date=March 25, 2018 |website=Sports Reference |language=en}} Hopkins, along with junior quarterback Tajh Boyd and wide receiver Sammy Watkins, combined to make one of the most prolific passing offenses in college football and broke many individual and career school records. He scored a touchdown in each of the last ten games of the season, doubling the previous school record for consecutive games with a score. Hopkins left Clemson with career record for receiving yards (3,020) and career touchdown receptions (27).{{Cite web |title=Clemson Tigers Receiving |url=https://www.sports-reference.com/cfb/schools/clemson/ |url-status=live |archive-url=https://web.archive.org/web/20180310015513/https://www.sports-reference.com/cfb/schools/clemson/ |archive-date=March 10, 2018 |access-date=January 30, 2019 |work=Sports Reference}} His 206 career receptions were the most by a Clemson receiver since Aaron Kelly had 232 from 2005 to 2008. On January 10, 2013, Hopkins decided to forgo his senior season at Clemson and enter the NFL Draft.{{Cite web |last=Conway |first=Tyler |date=January 10, 2013 |title=Clemson WR DeAndre Hopkins Officially Enters NFL Draft |url=http://bleacherreport.com/articles/1479696-clemson-wr-deandre-hopkins-officially-enters-nfl-draft |url-status=live |archive-url=https://web.archive.org/web/20170824222813/http://bleacherreport.com/articles/1479696-clemson-wr-deandre-hopkins-officially-enters-nfl-draft |archive-date=August 24, 2017 |access-date=August 24, 2017 |work=Bleacher Report}}

Coming out of Clemson, Hopkins was considered a top prospect and received an invitation to the NFL combine. He completed nearly all of the combine drills, but was unable to finish the three-cone drill after suffering an apparent calf injury. After the combine, the hotel room Hopkins shared with Rutgers wide receiver Mark Harrison was found to be left in a state where "urine and feces were found around the bathroom, toothpaste was left on the mirror and partially eaten food was on one of the beds," per ESPN. Both players denied responsibility.{{cite web |title=Sources: WRs occupied trashed hotel room |url=https://www.espn.com/nfl/draft2013/story/_/id/9187853/deandre-hopkins-mark-harrison-occupied-trashed-hotel-rooms-combine-sources-say |website=ESPN |date=2013-04-18 |archive-url=https://web.archive.org/web/20210724050539/https://www.espn.com/nfl/draft2013/story/_/id/9187853/deandre-hopkins-mark-harrison-occupied-trashed-hotel-rooms-combine-sources-say |archive-date=2021-07-24 |url-status=live |last1=Schefter |first1=Adam |author-link=Adam Schefter |access-date=July 24, 2021}}

On March 7, 2013, he participated in Clemson's pro day.{{Cite web |date=March 6, 2013 |title=Twelve Former Tigers at Pro Day Thursday |url=http://www.clemsontigers.com/ViewArticle.dbml?DB_OEM_ID=28500&ATCLID=206629361 |archive-url=https://web.archive.org/web/20171201034758/http://www.clemsontigers.com/ViewArticle.dbml?DB_OEM_ID=28500&ATCLID=206629361 |archive-date=December 1, 2017 |access-date=November 23, 2017 |work=Clemson Tigers Athletics}} Hopkins attended private workouts or visits with the Dallas Cowboys, Carolina Panthers, New England Patriots, and had two with the St. Louis Rams.{{cite news |title=NFL Draft private workout tracker 2013: The latest visit list from around the NFL |url=https://www.sbnation.com/nfl/2013/4/10/4207116/nfl-draft-private-workout-tracker-2013-updated-visitor-list |date=2013-04-10 |archive-url=https://web.archive.org/web/20190330044717/https://www.sbnation.com/platform/amp/nfl/2013/4/10/4207116/nfl-draft-private-workout-tracker-2013-updated-visitor-list |archive-date=2019-03-30 |url-status=live |work=SB Nation |last1=Gotta |first1=Griffin |access-date=November 24, 2017}}{{cite web |title=DeAndre Hopkins has second visit with the Rams |url=https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/deandre-hopkins-has-second-visit-with-the-rams |website=NBC Sports |date=2013-04-22 |last1=Alper |first1=Josh |access-date=2025-02-18 |language=en-US}}{{Cite web |last=Kyed |first=Doug |date=March 21, 2013 |title=Report: DeAndre Hopkins, Andre Ellington Had Private Workout With Patriots |url=https://nesn.com/2013/03/report-deandre-hopkins-andre-ellington-had-private-workout-with-patriots-last-week/ |url-status=live |archive-url=https://web.archive.org/web/20170616152539/http://nesn.com/2013/03/report-deandre-hopkins-andre-ellington-had-private-workout-with-patriots-last-week/ |archive-date=June 16, 2017 |access-date=November 24, 2017 |website=NESN.com}}

At the conclusion of the predraft process, Hopkins was projected to be a first or second round pick by NFL draft experts and scouts. He was ranked as the third best wide receiver prospect by NFL.com draft analyst Josh Norris, the fourth best wide receiver by Sports Illustrated, and was ranked the fifth best wide receiver by NFLDraftScout.com and NFL analyst Mike Mayock.{{Cite web |last=Mayock |first=Mike |author-link=Mike Mayock |date=April 19, 2013 |title=2013 NFL Draft: Mike Mayock's top 100 prospects |url=http://www.nfl.com/draft/story/0ap1000000146289/article/mike-mayock-alters-position-rankings-for-2013-nfl-draft |url-status=live |archive-url=https://web.archive.org/web/20171201030358/http://www.nfl.com/draft/story/0ap1000000146289/article/mike-mayock-alters-position-rankings-for-2013-nfl-draft |archive-date=December 1, 2017 |access-date=November 24, 2017 |website=NFL.com}}{{Cite web |last=Norris |first=Josh |date=April 10, 2013 |title=2013 NFL Draft: Tavon Austin headlines wide receiver rankings |url=https://www.nfl.com/news/2013-nfl-draft-tavon-austin-headlines-wide-receiver-rankings-0ap1000000158865 |url-status=live |archive-url=https://web.archive.org/web/20171201040804/http://www.nfl.com/news/story/0ap1000000158865/article/2013-nfl-draft-tavon-austin-headlines-wide-receiver-rankings |archive-date=December 1, 2017 |access-date=November 24, 2017 |website=NFL.com}}{{cite web |title=2013 NFL Draft Position Rankings: Offense |url=https://www.si.com/nfl/audibles/2013/03/26/2013-nfl-draft-position-rankings-offense |website=Sports Illustrated |date=2013-03-26 |archive-url=https://web.archive.org/web/20171201040453/https://www.si.com/nfl/audibles/2013/03/26/2013-nfl-draft-position-rankings-offense |archive-date=2017-12-01 |url-status=live |last1=Burke |first1=Chris |access-date=November 24, 2017}}

{{NFL predraft

| height ft = 6

| height in = 1

| weight = 214

| dash = 4.57

| twenty split = 2.69

| ten split = 1.62

| shuttle = 4.50

| cone drill = 6.83

| vertical = 36

| broad ft = 9

| broad in = 7

| bench = 15

| hand span = 10

| arm span = 33 3/8

| note = All results from NFL Combine/Clemson's Pro Day{{Cite web |title=NFL Events: Combine Player Profiles – DeAndre Hopkins |url=http://www.nfl.com/combine/profiles/deandre-hopkins?id=2540165 |url-status=live |archive-url=https://web.archive.org/web/20200418053248/http://www.nfl.com/combine/profiles/deandre-hopkins?id=2540165 |archive-date=April 18, 2020 |access-date=May 1, 2020 |website=NFL.com}}{{Cite web |title=*DeAndre Hopkins – Clemson, WR : 2013 NFL Draft Scout Player Profile |url=http://www.nfldraftscout.com/ratings/dsprofile.php?pyid=108645&draftyear=2013&genpos=WR |url-status=dead |archive-url=https://web.archive.org/web/20170811104959/http://www.nfldraftscout.com/ratings/dsprofile.php?pyid=108645&draftyear=2013&genpos=WR |archive-date=August 11, 2017 |access-date=September 15, 2013 |website=NFLDraftScout.com}}

}}

The Houston Texans selected Hopkins in the first round with the 27th overall pick in the 2013 NFL draft.{{Cite web |date=April 26, 2013 |title=Houston Texans take DeAndre Hopkins at No. 27 in NFL draft |url=https://www.nfl.com/news/houston-texans-take-deandre-hopkins-at-no-27-in-nfl-draft-0ap1000000164015 |url-status=live |archive-url=https://web.archive.org/web/20220618033025/https://www.nfl.com/news/houston-texans-take-deandre-hopkins-at-no-27-in-nfl-draft-0ap1000000164015 |archive-date=June 18, 2022 |access-date=June 18, 2022 |website=NFL.com}} He was the second wide receiver selected, behind Tavon Austin (Rams, eighth overall).{{Cite web |title=2013 NFL Draft Listing |url=https://www.pro-football-reference.com/years/2013/draft.htm |url-status=live |archive-url=https://web.archive.org/web/20181002095516/https://www.pro-football-reference.com/years/2013/draft.htm |archive-date=October 2, 2018 |access-date=August 24, 2017 |website=Pro Football Reference}} Hopkins was the second wide receiver in franchise history to be drafted in the first round, the first being Andre Johnson who was selected third overall in 2003. It was also just the second time in 10 years that the Texans selected an offensive player (the other selection was left tackle Duane Brown) in the first round.{{Cite web |title=Houston Texans All-Time Draft History |url=https://www.pro-football-reference.com/teams/htx/draft.htm |url-status=live |archive-url=https://web.archive.org/web/20180325233252/https://www.pro-football-reference.com/teams/htx/draft.htm |archive-date=March 25, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}} He became the highest wide receiver out of Clemson since Rod Gardner went 15th overall in 2001.{{Cite web |title=Clemson Players/Alumni |url=https://www.pro-football-reference.com/schools/clemson/index.htm |url-status=live |archive-url=https://web.archive.org/web/20210430020721/https://www.pro-football-reference.com/schools/clemson/index.htm |archive-date=April 30, 2021 |access-date=February 2, 2021 |work=Pro Football Reference}} On July 24, 2013, Hopkins signed a four-year, $7.62 million contract with the team. The first three years of the contract were fully guaranteed.{{Cite web |last=McClain |first=John |author-link=John McClain |date=July 22, 2013 |title=Texans sign first-round pick DeAndre Hopkins |url=http://blog.chron.com/ultimatetexans/2013/07/texans-sign-first-round-pick-deandre-hopkins/ |url-status=live |archive-url=https://web.archive.org/web/20130725055003/http://blog.chron.com/ultimatetexans/2013/07/texans-sign-first-round-pick-deandre-hopkins/ |archive-date=July 25, 2013 |access-date=May 1, 2020 |website=Chron.com}}{{Cite web |title=Spotrac.com: DeAndre Hopkins contract |url=http://www.spotrac.com/nfl/houston-texans/deandre-hopkins-12307/ |url-status=live |archive-url=https://web.archive.org/web/20171119202847/http://www.spotrac.com/nfl/houston-texans/deandre-hopkins-12307/ |archive-date=November 19, 2017 |access-date=November 24, 2017 |website=spotrac.com}}

Hopkins made his NFL debut in the season opener against the San Diego Chargers and made five receptions for 55 yards in the 31–28 victory, a game where the Texans at one point trailed 28–7.{{Cite web |date=September 10, 2013 |title=Texans rally from 21 down to stun Chargers 31–28 |url=https://www.sandiegouniontribune.com/sdut-texans-rally-from-21-down-to-stun-chargers-31-28-2013sep09-story.html |url-status=live |archive-url=https://web.archive.org/web/20230122051258/https://www.sandiegouniontribune.com/sdut-texans-rally-from-21-down-to-stun-chargers-31-28-2013sep09-story.html |archive-date=January 22, 2023 |access-date=June 26, 2022 |work=San Diego Union-Tribune}} His first NFL reception came on a pass from Matt Schaub for no gain in the second quarter.{{Cite web |title=Houston Texans at San Diego Chargers – September 9th, 2013 |url=https://www.pro-football-reference.com/boxscores/201309090sdg.htm |url-status=live |archive-url=https://web.archive.org/web/20170824220847/https://www.pro-football-reference.com/boxscores/201309090sdg.htm |archive-date=August 24, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}} On September 15, Hopkins caught a season-high seven passes for 117 receiving yards and scored his first career touchdown reception on a three-yard pass from quarterback Matt Schaub in the Texans' 30–24 overtime victory against the Tennessee Titans. It was Hopkins's first game with over one hundred receiving yards.{{Cite web |last=Sidhu |first=Deepi |date=September 15, 2013 |title=Texans win overtime thriller |url=http://www.houstontexans.com/news/article-2/Texans-win-overtime-thriller-/33dd415f-51da-4098-a2ee-d1a1fcd108eb |url-status=dead |archive-url=https://web.archive.org/web/20170811142736/http://www.houstontexans.com/news/article-2/Texans-win-overtime-thriller-/33dd415f-51da-4098-a2ee-d1a1fcd108eb |archive-date=August 11, 2017 |access-date=September 15, 2013 |work=Houston Texans}} Hopkins was named the NFL Rookie of the Month for September.{{Cite web |title=Houston Texans 2020 Football Media Guide |url=https://static.nfl.com/static/content/public/static/pdf/media-guides/HOU-Media-Guide.pdf |url-status=live |archive-url=https://web.archive.org/web/20210206125528/https://static.nfl.com/static/content/public/static/pdf/media-guides/HOU-Media-Guide.pdf |archive-date=February 6, 2021 |access-date=February 2, 2021 |website=NFL.com}} In Week 7, he caught three passes for 76 yards and scored a touchdown on a 29-yard pass from Case Keenum during a 16–17 loss to Kansas City Chiefs.{{Cite web |title=Houston Texans at Kansas City Chiefs – October 20th, 2013 |url=https://www.pro-football-reference.com/boxscores/201310200kan.htm |url-status=live |archive-url=https://web.archive.org/web/20180119235032/https://www.pro-football-reference.com/boxscores/201310200kan.htm |archive-date=January 19, 2018 |access-date=May 1, 2020 |work=Pro Football Reference}} On December 2, 2013, Head coach Gary Kubiak was fired after the Texans posted a 2–11 record.{{Cite web |last=Gantt |first=Darin |date=December 6, 2013 |title=Gary Kubiak fired by Texans after 11th straight loss |url=https://profootballtalk.nbcsports.com/2013/12/06/gary-kubiak-fired-by-texans-after-11th-straight-loss/ |url-status=live |archive-url=https://web.archive.org/web/20201111182511/https://profootballtalk.nbcsports.com/2013/12/06/gary-kubiak-fired-by-texans-after-11th-straight-loss/ |archive-date=November 11, 2020 |access-date=October 30, 2020 |work=ProFootballTalk}} Hopkins finished the {{NFL Year|2013}} season with 52 receptions for 802 receiving yards and two touchdowns. His rookie season was marred by inconsistent quarterback play by Matt Schaub that led to Schaub's benching after nine interceptions in five games.{{Cite web |title=DeAndre Hopkins 2013 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2013 |url-status=live |archive-url=https://web.archive.org/web/20170825020905/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2013 |archive-date=August 25, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}} Hopkins was named to the NFL All-Rookie Team for the 2013 season.{{Cite web |title=2013 NFL All-Rookie Team |url=https://www.pro-football-reference.com/awards/nfl-all-rookie-2013.htm |url-status=live |archive-url=https://web.archive.org/web/20180325233211/https://www.pro-football-reference.com/awards/nfl-all-rookie-2013.htm |archive-date=March 25, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}}

File:DeAndre Hopkins.JPG

Hopkins returned as a starting wide receiver alongside Andre Johnson under new head coach Bill O'Brien to begin the 2014 season.{{Cite web |title=Houston Texans Depth Chart Archive |url=https://www.ourlads.com/nfldepthcharts/archive/162/HOU |url-status=live |archive-url=https://web.archive.org/web/20220130185310/https://www.ourlads.com/nfldepthcharts/archive/162/HOU |archive-date=January 30, 2022 |access-date=January 30, 2022 |website=Ourlads.com}}

Hopkins started in the season-opening 17–6 victory over the Washington Redskins and caught four passes for 89 yards and scored a new career-long 76-yard touchdown on a pass by quarterback Ryan Fitzpatrick.{{Cite web |last=Sidhu |first=Deepi |date=September 7, 2014 |title=DeAndre Hopkins scores on career-long TD |url=http://www.houstontexans.com/news/article-2/DeAndre-Hopkins-scores-on-career-long-TD/779bbeab-9a19-4248-a0ff-8afb9ce289ce |url-status=dead |archive-url=https://web.archive.org/web/20170811104749/http://www.houstontexans.com/news/article-2/DeAndre-Hopkins-scores-on-career-long-TD/779bbeab-9a19-4248-a0ff-8afb9ce289ce |archive-date=August 11, 2017 |access-date=September 7, 2014 |work=Houston Texans}} In Week 3, he had six receptions for 116 yards during a 30–14 victory over the New York Giants.{{Cite web |title=Houston Texans at New York Giants – September 21st, 2014 |url=https://www.pro-football-reference.com/boxscores/201409210nyg.htm |url-status=live |archive-url=https://web.archive.org/web/20170824233014/https://www.pro-football-reference.com/boxscores/201409210nyg.htm |archive-date=August 24, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}} In the game, Hopkins had a spectacular one-handed 53-yard catch that was negated by an illegal formation penalty.{{Cite web |last=Newport |first=Kyle |date=September 21, 2014 |title=Texans' DeAndre Hopkins Makes Great 1-Handed Catch Against Giants |url=http://bleacherreport.com/articles/2205980-texans-deandre-hopkins-makes-great-1-handed-catch-against-giants |url-status=live |archive-url=https://web.archive.org/web/20170824221352/http://bleacherreport.com/articles/2205980-texans-deandre-hopkins-makes-great-1-handed-catch-against-giants |archive-date=August 24, 2017 |access-date=August 24, 2017 |work=Bleacher Report}} During a Week 7 matchup against the Pittsburgh Steelers, Hopkins made six receptions for 108 receiving yards in a 23–30 loss.{{Cite web |title=Houston Texans at Pittsburgh Steelers – October 20th, 2014 |url=https://www.pro-football-reference.com/boxscores/201410200pit.htm |url-status=live |archive-url=https://web.archive.org/web/20170824233010/https://www.pro-football-reference.com/boxscores/201410200pit.htm |archive-date=August 24, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}} On November 30, 2014, Hopkins caught a season-high nine passes for a season-high 238 receiving yards and two touchdowns as the Texans routed the Titans 45–21 in Week 13.{{Cite web |title=Tennessee Titans at Houston Texans – November 30th, 2014 |url=https://www.pro-football-reference.com/boxscores/201411300htx.htm |url-status=live |archive-url=https://web.archive.org/web/20170825020447/https://www.pro-football-reference.com/boxscores/201411300htx.htm |archive-date=August 25, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}} Hopkins was the Texans' leading receiver in {{NFL year|2014}}, recording 76 receptions for 1,210 yards and six touchdowns in 16 games and 16 starts.{{Cite web |title=DeAndre Hopkins 2014 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2014 |url-status=live |archive-url=https://web.archive.org/web/20170825020319/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2014 |archive-date=August 25, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}}

Hopkins was solidified as the Texans' number one receiver to begin the 2015 season after veteran Andre Johnson departed to the Indianapolis Colts in free agency.{{cite web |title=The Texans have released wide receiver Andre Johnson |url=https://www.si.com/nfl/2015/03/09/houston-texans-andre-johnson-released-free-agency |website=Sports Illustrated |date=2015-03-09 |archive-url=https://web.archive.org/web/20181012053939/https://www.si.com/nfl/2015/03/09/houston-texans-andre-johnson-released-free-agency |archive-date=2018-10-12 |url-status=live |last1=Axson |first1=Scooby |access-date=October 11, 2018}}

Hopkins started in the Texans' season-opener against the Chiefs and caught nine passes for 98 yards and two touchdowns as the Texans lost 27–20.{{Cite web |title=Kansas City Chiefs at Houston Texans – September 13th, 2015 |url=https://www.pro-football-reference.com/boxscores/201509130htx.htm |url-status=live |archive-url=https://web.archive.org/web/20180111170752/https://www.pro-football-reference.com/boxscores/201509130htx.htm |archive-date=January 11, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}} Two weeks later, he recorded his first 100-yard receiving game of the season, with eight receptions for 101 yards and a touchdown in a 19–9 victory over the Tampa Bay Buccaneers.{{Cite web |title=Tampa Bay Buccaneers at Houston Texans – September 27th, 2015 |url=https://www.pro-football-reference.com/boxscores/201509270htx.htm |url-status=live |archive-url=https://web.archive.org/web/20180307082244/https://www.pro-football-reference.com/boxscores/201509270htx.htm |archive-date=March 7, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}} Hopkins increased his production the following week, recording nine receptions for 157 yards in a 48–21 loss to the Atlanta Falcons.{{Cite web |title=Houston Texans at Atlanta Falcons – October 4th, 2015 |url=https://www.pro-football-reference.com/boxscores/201510040atl.htm |url-status=live |archive-url=https://web.archive.org/web/20171210072013/https://www.pro-football-reference.com/boxscores/201510040atl.htm |archive-date=December 10, 2017 |access-date=March 25, 2018 |work=Pro Football Reference}} During Week 6 against the Jacksonville Jaguars he had 10 receptions for 142 yards and two touchdowns to earn his first career AFC Offensive Player of the Week award.{{Cite web |title=Houston Texans at Jacksonville Jaguars – October 18th, 2015 |url=https://www.pro-football-reference.com/boxscores/201510180jax.htm |url-status=live |archive-url=https://web.archive.org/web/20170828233450/https://www.pro-football-reference.com/boxscores/201510180jax.htm |archive-date=August 28, 2017 |access-date=March 25, 2018 |work=Pro Football Reference}}{{Cite web |title=2015 NFL Week 6 Leaders & Scores |url=https://www.pro-football-reference.com/years/2015/week_6.htm |url-status=live |archive-url=https://web.archive.org/web/20180326063916/https://www.pro-football-reference.com/years/2015/week_6.htm |archive-date=March 26, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}} During Week 13 against the Buffalo Bills, Hopkins broke the Texans' franchise record for most touchdown receptions in a season, which was formerly held by Andre Johnson,{{cite web |title=Hopkins set Texans single season TD record |url=https://www.houstontexans.com/news/hopkins-set-texans-single-season-td-record-16440568 |website=Houston Texans |date=2015-12-06 |archive-url=https://web.archive.org/web/20210417144720/https://www.houstontexans.com/news/hopkins-set-texans-single-season-td-record-16440568 |archive-date=2021-04-17 |url-status=live |last1=Dougherty |first1=Drew |access-date=October 30, 2020}} with his tenth score. In the 2015 season, his usage increased to 192 targets, which ranked third among NFL wide receivers, trailing only Antonio Brown of the Steelers and Julio Jones of the Falcons.{{Cite web |title=DeAndre Hopkins Advanced Stats and Metrics Profile: Efficiency |url=http://www.playerprofiler.com/nfl/deandre-hopkins |url-status=live |archive-url=https://web.archive.org/web/20200531093451/https://www.playerprofiler.com/nfl/deandre-hopkins/ |archive-date=May 31, 2020 |access-date=May 1, 2020 |website=PlayerProfiler.com}}{{Cite web |title=2015 NFL Receiving |url=https://www.pro-football-reference.com/years/2015/receiving.htm |url-status=live |archive-url=https://web.archive.org/web/20170824233012/https://www.pro-football-reference.com/years/2015/receiving.htm |archive-date=August 24, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}}

File:NFL Players Before 2016 Pro Bowl.jpg]]

Hopkins finished the 2015 season with then-career highs in receptions (111), receiving yards (1,521), and touchdowns (11), despite playing with four different quarterbacks (Brian Hoyer, Ryan Mallett, T. J. Yates, and Brandon Weeden).{{cite web |title=4 QBs, zero problems for WR DeAndre Hopkins |url=https://www.houstontexans.com/news/4-qbs-zero-problems-for-wr-deandre-hopkins-16656561 |website=Houston Texans |date=2016-01-06 |archive-url=https://web.archive.org/web/20210830172645/https://www.houstontexans.com/news/4-qbs-zero-problems-for-wr-deandre-hopkins-16656561 |archive-date=2021-08-30 |url-status=live |access-date=June 18, 2022}} He earned his first career Pro Bowl nomination and was named second-team All-Pro.{{Cite web |title=2015 NFL Pro Bowlers |url=https://www.pro-football-reference.com/years/2015/probowl.htm |url-status=live |archive-url=https://web.archive.org/web/20180308103829/https://www.pro-football-reference.com/years/2015/probowl.htm |archive-date=March 8, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}} He was also ranked 19th by his fellow players on the NFL Top 100 Players of 2016.{{Cite web |title=2016 NFL Top 100 |url=https://www.pro-football-reference.com/awards/2016-nfl-top-100.htm |url-status=live |archive-url=https://web.archive.org/web/20210108032657/https://www.pro-football-reference.com/awards/2016-nfl-top-100.htm |archive-date=January 8, 2021 |access-date=June 18, 2022 |work=Pro Football Reference}}

On July 30, 2016, Hopkins did not report to training camp after he announced he was holding out for a new contract.{{Cite news |last=Eilerson |first=Nick |date=July 30, 2016 |title=Houston Texans' top target DeAndre Hopkins holding out of training camp |url=https://www.washingtonpost.com/news/early-lead/wp/2016/07/30/houston-texans-top-target-deandre-hopkins-holding-out-of-training-camp/ |url-status=live |archive-url=https://web.archive.org/web/20190102135052/https://www.washingtonpost.com/news/early-lead/wp/2016/07/30/houston-texans-top-target-deandre-hopkins-holding-out-of-training-camp/ |archive-date=January 2, 2019 |access-date=May 1, 2020 |work=Washington Post}}

On September 15, 2016, Hopkins was fined $6,076 for an equipment violation regarding improper cleats on his shoes. The cleats were revealed to be Yeezy 350 Boosts cleats designed by Kanye West.{{cite web |title=DeAndre Hopkins fined for Yeezy 350 Boosts cleats designed by Kanye West |url=https://www.espn.com/nfl/story/_/id/17556327/deandre-hopkins-houston-texans-fined-6k-yeezy-cleats |website=ESPN |date=2016-09-15 |archive-url=https://web.archive.org/web/20170520134054/http://www.espn.com/nfl/story/_/id/17556327/deandre-hopkins-houston-texans-fined-6k-yeezy-cleats |archive-date=2017-05-20 |url-status=live |last1=Barshop |first1=Sarah |access-date=September 15, 2016}} In the 2016 season, Hopkins suffered through some small regression as the quarterback play of Brock Osweiler lacked positive consistency.{{Cite web |last=Wilson |first=Aaron |date=December 11, 2016 |title=Several factors contributing to Texans wide receiver DeAndre Hopkins' lessened production |url=https://www.houstonchronicle.com/sports/texans/article/Several-factors-contributing-to-Texans-wide-10788532.php |url-status=live |archive-url=https://web.archive.org/web/20220618033025/https://www.houstonchronicle.com/sports/texans/article/Several-factors-contributing-to-Texans-wide-10788532.php |archive-date=June 18, 2022 |access-date=June 18, 2022 |work=Houston Chronicle}} The Texans finished atop the AFC South with a 9–7 record.{{Cite web |title=2016 Houston Texans Statistics & Players |url=https://www.pro-football-reference.com/teams/htx/2016.htm |url-status=live |archive-url=https://web.archive.org/web/20180111170732/https://www.pro-football-reference.com/teams/htx/2016.htm |archive-date=January 11, 2018 |access-date=March 25, 2018 |website=Pro Football Reference |language=en}} In the Wild Card Round, against the Oakland Raiders, Hopkins had five receptions for 67 yards and a touchdown in the 27–14 victory.{{Cite web |title=Wild Card – Oakland Raiders at Houston Texans – January 7th, 2017 |url=https://www.pro-football-reference.com/boxscores/201701070htx.htm |url-status=live |archive-url=https://web.archive.org/web/20171015050107/https://www.pro-football-reference.com/boxscores/201701070htx.htm |archive-date=October 15, 2017 |access-date=January 22, 2023 |work=Pro Football Reference}} The Texans went on to lose in the Divisional Round of the 2016–17 NFL playoffs to the eventual Super Bowl champion Patriots. Hopkins had six receptions for 65 yards in the 34–16 loss.{{Cite web |title=Divisional Round – Houston Texans at New England Patriots – January 14th, 2017 |url=https://www.pro-football-reference.com/boxscores/201701140nwe.htm |url-status=live |archive-url=https://web.archive.org/web/20181203061940/https://www.pro-football-reference.com/boxscores/201701140nwe.htm |archive-date=December 3, 2018 |access-date=January 22, 2023 |work=Pro Football Reference}}

Hopkins had 78 receptions for 954 yards and four touchdowns in the 2016 season, all his lowest totals since his rookie season in 2013.{{Cite web |title=DeAndre Hopkins Career Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/ |url-status=live |archive-url=https://web.archive.org/web/20170824215755/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/ |archive-date=August 24, 2017 |access-date=August 24, 2017 |website=Pro Football Reference}}

On August 31, 2017, the Houston Texans signed Hopkins to a five-year, $81 million contract extension with $49 million guaranteed and a signing bonus of $7.5 million.{{Cite web |last=Patra |first=Kevin |date=August 31, 2017 |title=DeAndre Hopkins, Texans agree on 5-year, $81M deal |url=http://www.nfl.com/news/story/0ap3000000837455/article/texans-finalizing-5year-contract-for-deandre-hopkins |url-status=dead |archive-url=https://web.archive.org/web/20190608202454/http://www.nfl.com/news/story/0ap3000000837455/article/texans-finalizing-5year-contract-for-deandre-hopkins |archive-date=June 8, 2019 |website=NFL.com}}

During the season-opening 29–7 loss to the Jaguars, Hopkins caught the first NFL touchdown pass of quarterback and fellow Clemson Tiger Deshaun Watson's career.{{cite web |title=Texans QB Deshaun Watson Throws 1st Career Touchdown vs. Jaguars |url=https://bleacherreport.com/articles/2732492-texans-qb-deshaun-watson-throws-first-career-touchdown-vs-jaguars |website=Bleacher Report |date=2017-09-10 |archive-url=https://web.archive.org/web/20220618032249/https://bleacherreport.com/articles/2732492-texans-qb-deshaun-watson-throws-first-career-touchdown-vs-jaguars |archive-date=2022-06-18 |url-status=live |last1=Wassink |first1=Zac |access-date=June 18, 2022}} He finished with seven receptions for 55 yards and a touchdown.{{Cite web |title=Jacksonville Jaguars at Houston Texans – September 10th, 2017 |url=https://www.pro-football-reference.com/boxscores/201709100htx.htm |url-status=live |archive-url=https://web.archive.org/web/20210108032711/https://www.pro-football-reference.com/boxscores/201709100htx.htm |archive-date=January 8, 2021 |access-date=October 6, 2017 |website=Pro Football Reference}} During Week 8 against the Seattle Seahawks, Hopkins posted an impressive performance with eight receptions for 224 receiving yards, which was highlighted by a 72-yard touchdown. However, his performance was overshadowed as the Texans lost on the road by a score of 38–41.{{Cite web |title=Houston Texans at Seattle Seahawks – October 29th, 2017 |url=https://www.pro-football-reference.com/boxscores/201710290sea.htm |url-status=live |archive-url=https://web.archive.org/web/20171108032544/https://www.pro-football-reference.com/boxscores/201710290sea.htm |archive-date=November 8, 2017 |access-date=November 7, 2017 |work=Pro Football Reference}} On December 19, 2017, Hopkins was named to his second Pro Bowl.{{Cite web |date=December 19, 2017 |title=NFL announces 2018 Pro Bowl rosters |url=https://www.nfl.com/news/updated-player-rosters-for-2018-pro-bowl-in-orlando-0ap3000000895772 |url-status=live |archive-url=https://web.archive.org/web/20171220125215/http://www.nfl.com/news/story/0ap3000000895772/article/nfl-announces-2018-pro-bowl-rosters |archive-date=December 20, 2017 |access-date=December 23, 2017 |website=NFL.com}} Hopkins did not play in Week 17 due to a calf injury.{{Cite web |last=Patra |first=Kevin |date=December 28, 2017 |title=Injuries: DeAndre Hopkins expected to sit out Sunday |url=https://www.nfl.com/news/injuries-deandre-hopkins-expected-to-sit-out-sunday-0ap3000000899523 |url-status=live |archive-url=https://web.archive.org/web/20180101020832/http://www.nfl.com/news/story/0ap3000000899523/article/injuries-deandre-hopkins-expected-to-sit-out-sunday |archive-date=January 1, 2018 |access-date=January 1, 2018 |website=NFL}}

Hopkins finished the 2017 season with 96 receptions for 1,378 yards and a league-leading 13 touchdowns. He led the league in scoring among wide receivers with 78 points.{{Cite web |title=2017 NFL Scoring Summary |url=https://www.pro-football-reference.com/years/2017/scoring.htm |url-status=live |archive-url=https://web.archive.org/web/20180127214418/https://www.pro-football-reference.com/years/2017/scoring.htm |archive-date=January 27, 2018 |access-date=February 25, 2018 |work=Pro Football Reference}} He became the first player in franchise history to lead the league in receiving touchdowns for a single season.{{Cite web |title=NFL Receiving Touchdowns Year-by-Year Leaders |url=https://www.pro-football-reference.com/leaders/rec_td_year_by_year.htm |url-status=live |archive-url=https://web.archive.org/web/20181012014621/https://www.pro-football-reference.com/leaders/rec_td_year_by_year.htm |archive-date=October 12, 2018 |access-date=January 22, 2023 |work=Pro Football Reference}} He was named as a First-team All-Pro for the 2017 season and was ranked 13th by his fellow players on the NFL Top 100 Players of 2018.{{Cite web |title=2017 NFL All-Pros |url=https://www.pro-football-reference.com/years/2017/allpro.htm |url-status=live |archive-url=https://web.archive.org/web/20180329105114/https://www.pro-football-reference.com/years/2017/allpro.htm |archive-date=March 29, 2018 |access-date=March 25, 2018 |work=Pro Football Reference}}{{Cite web |last=Wilson |first=Aaron |date=June 19, 2018 |title=Texans' DeAndre Hopkins ranked 13th in NFL Network top 100 list |url=https://www.sfgate.com/sports/texans/article/Texans-DeAndre-Hopkins-13-NFL-Network-top-100-13005613.php |url-status=live |archive-url=https://web.archive.org/web/20181010011248/https://www.sfgate.com/sports/texans/article/Texans-DeAndre-Hopkins-13-NFL-Network-top-100-13005613.php |archive-date=October 10, 2018 |access-date=October 11, 2018 |work=SFGate}}

During Week 2, Hopkins had six catches for 110 yards and a touchdown in a 20–17 road loss against the Titans.{{Cite web |last=Dougherty |first=Drew |date=September 16, 2018 |title=DeAndre Hopkins scores, cracks 100-yd mark at Tennessee |url=https://www.houstontexans.com/news/watson-to-hopkins-connection-gets-texans-a-td |url-status=live |archive-url=https://web.archive.org/web/20180917005626/https://www.houstontexans.com/news/watson-to-hopkins-connection-gets-texans-a-td |archive-date=September 17, 2018 |access-date=October 11, 2018 |work=Houston Texans}} During Week 4 against the Colts, he had 10 receptions for 169 yards and a touchdown in the 37–34 overtime victory.{{Cite web |last=Wood |first=Anthony R. |date=October 1, 2018 |title=DeAndre Hopkins unfazed by previous losses |url=https://texanswire.usatoday.com/2018/10/01/texans-wr-deandre-hopkins-unfazed-previous-losses/ |url-status=live |archive-url=https://web.archive.org/web/20181011214720/https://texanswire.usatoday.com/2018/10/01/texans-wr-deandre-hopkins-unfazed-previous-losses/ |archive-date=October 11, 2018 |access-date=October 11, 2018 |work=USA Today}} In the following game, on Sunday Night Football against the Cowboys, he had nine receptions for 151 yards, which included a key 49 yard catch-and-run in overtime to help set up the game-winning field goal.{{cite web |title=Texans' DeAndre Hopkins: Records 151 yards in OT victory |url=https://www.cbssports.com/fantasy/football/news/texans-deandre-hopkins-records-151-receiving-yards-in-ot-victory/ |website=CBS Sports |date=2018-10-07 |archive-url=https://web.archive.org/web/20220626202000/https://www.cbssports.com/fantasy/football/news/texans-deandre-hopkins-records-151-yards-in-ot-victory/ |archive-date=2022-06-26 |url-status=live |access-date=October 11, 2018}}{{cite web |title=DeAndre Hopkins' ridiculous double spin move puts Cowboys on ice, ignites NFL Twitter |url=https://www.cbssports.com/nfl/news/deandre-hopkins-ridiculous-double-spin-move-puts-cowboys-on-ice-ignites-nfl-twitter/ |website=CBS Sports |date=2018-10-08 |archive-url=https://web.archive.org/web/20181012014450/https://www.cbssports.com/nfl/news/deandre-hopkins-ridiculous-double-spin-move-puts-cowboys-on-ice-ignites-nfl-twitter/ |archive-date=2018-10-12 |url-status=live |last1=Skiver |first1=Kevin |access-date=October 11, 2018}}

Hopkins finished the 2018 season with a career-high 115 catches for a career-high 1,572 receiving yards and 11 touchdowns.{{Cite web |title=DeAndre Hopkins 2018 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2018/ |url-status=live |archive-url=https://web.archive.org/web/20220130185522/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2018/ |archive-date=January 30, 2022 |access-date=January 30, 2022 |work=Pro Football Reference}} He finished third in the league in receptions and second in receiving yards.{{Cite web |title=2018 NFL Receiving |url=https://www.pro-football-reference.com/years/2018/receiving.htm |url-status=live |archive-url=https://web.archive.org/web/20201005170531/https://www.pro-football-reference.com/years/2018/receiving.htm |archive-date=October 5, 2020 |access-date=January 30, 2019 |work=Pro Football Reference}} He was named to his third Pro Bowl and his second straight First-team All-Pro.{{Cite web |last=Teope |first=Herbie |date=January 4, 2019 |title=All-Pro Team: Donald, Mahomes among highlights |url=https://www.nfl.com/news/all-pro-team-donald-mahomes-among-highlights-0ap3000001007645 |url-status=live |archive-url=https://web.archive.org/web/20190807044014/http://www.nfl.com/news/story/0ap3000001007645/article/allpro-team-patrick-mahomes-among-2018-highlights |archive-date=August 7, 2019 |access-date=July 23, 2019 |website=NFL.com}} The Texans won the AFC South win an 11–5 record and earned the #3-seed for the AFC Playoffs.{{Cite web |title=2018 Houston Texans Statistics & Players |url=https://www.pro-football-reference.com/teams/htx/2018.htm |url-status=live |archive-url=https://web.archive.org/web/20190203141710/https://www.pro-football-reference.com/teams/htx/2018.htm |archive-date=February 3, 2019 |access-date=January 30, 2019 |work=Pro Football Reference}} In the Wild Card Round against the Colts, playing with a torn ligament in his shoulder, he finished with five receptions for 37 yards in the 21–7 loss.{{Cite web |title=Wild Card – Indianapolis Colts at Houston Texans – January 5th, 2019 |url=https://www.pro-football-reference.com/boxscores/201901050htx.htm |url-status=live |archive-url=https://web.archive.org/web/20190122044017/https://www.pro-football-reference.com/boxscores/201901050htx.htm |archive-date=January 22, 2019 |access-date=January 30, 2019 |work=Pro Football Reference}} He was ranked 11th by his fellow players on the NFL Top 100 Players of 2019.{{Cite web |title=2019 NFL Top 100 |url=https://www.pro-football-reference.com/awards/2019-nfl-top-100.htm |url-status=live |archive-url=https://web.archive.org/web/20220511024217/https://www.pro-football-reference.com/awards/2019-nfl-top-100.htm |archive-date=May 11, 2022 |access-date=June 18, 2022 |work=Pro Football Reference}}

In the season-opener against the New Orleans Saints, Hopkins had eight receptions for 111 receiving yards and two receiving touchdowns in the narrow 30–28 road loss.{{cite web |title=Lutz's 58-yard field goal lifts Saints over Texans, 30–28 |url=https://www.espn.com/nfl/recap?gameId=401128021 |website=ESPN |date=2019-09-09 |archive-url=https://web.archive.org/web/20191227103301/https://www.espn.com/nfl/recap?gameId=401128021 |archive-date=2019-12-27 |url-status=live |access-date=September 9, 2019 |agency=Associated Press}} Three weeks later against the Panthers, he caught five passes for 41 receiving yards and threw an interception in a 16–10 loss.{{cite web |title=Panthers down Texans 16–10 despite Allen's fumbles |url=https://www.espn.com/nfl/recap?gameId=401128026 |website=ESPN |date=2019-09-29 |archive-url=https://web.archive.org/web/20190930071518/https://www.espn.com/nfl/recap?gameId=401128026 |archive-date=2019-09-30 |url-status=live |access-date=September 29, 2019 |agency=Associated Press}} During Week 7 against the Colts, Hopkins caught nine passes for 106 receiving yards and a receiving touchdown in the 30–23 road loss.{{cite web |title=Colts take AFC South lead with 30–23 victory over Texans |url=https://www.espn.com/nfl/recap?gameId=401127951 |website=ESPN |date=2019-10-20 |archive-url=https://web.archive.org/web/20220315211532/https://www.espn.com/nfl/recap?gameId=401127951 |archive-date=2022-03-15 |url-status=live |access-date=October 20, 2019 |agency=Associated Press}} In the next game against the Raiders, Hopkins caught a season-high 11 passes for 109 receiving yards in the 27–24 victory.{{cite web |title=Watson's 3 TD passes lead Texans over Raiders 27–24 |url=https://www.espn.com/nfl/recap?gameId=401128043 |website=ESPN |date=2019-10-27 |archive-url=https://web.archive.org/web/20191214062558/https://www.espn.com/nfl/recap?gameId=401128043 |archive-date=2019-12-14 |url-status=live |access-date=October 27, 2019 |agency=Associated Press}} During Week 12 against the Colts, Hopkins caught six catches for 94 receiving yards and two receiving touchdowns in the 20–17 win.{{cite web |title=Hopkins has 2 TDs, Texans beat Colts 20–17 to top AFC South |url=https://www.espn.com/nfl/recap?gameId=401127865 |website=ESPN |date=2019-11-21 |archive-url=https://web.archive.org/web/20191125021215/https://www.espn.com/nfl/recap?gameId=401127865 |archive-date=2019-11-25 |url-status=live |access-date=November 21, 2019 |agency=Associated Press}} In the next game against the Patriots, he caught five passes for 64 receiving yards and threw a six-yard touchdown pass to quarterback Deshaun Watson during the 28–22 win.{{cite web |title=Watson throws 3 TDs, catches another; Texans top Pats 28–22 |url=https://www.espn.com/nfl/recap?gameId=401127967 |website=ESPN |date=2019-12-01 |archive-url=https://web.archive.org/web/20191203161827/https://www.espn.com/nfl/recap?gameId=401127967 |archive-date=2019-12-03 |url-status=live |access-date=December 1, 2019 |agency=Associated Press}} In the following week's game against the Denver Broncos, Hopkins caught seven passes for 120 receiving yards and a receiving touchdown during the 38–24 loss.{{cite web |title=Lock throws 3 TDs in first half as Broncos beat Texans 38–24 |url=https://www.espn.com/nfl/recap?gameId=401127920 |website=ESPN |date=2019-12-08 |archive-url=https://web.archive.org/web/20191210191927/https://www.espn.com/nfl/recap?gameId=401127920 |archive-date=2019-12-10 |url-status=live |access-date=December 8, 2019 |agency=Associated Press}} During Week 15 against the Titans, he had six receptions for 119 receiving yards in the 24–21 road victory.{{Cite web |title=Houston Texans at Tennessee Titans – December 15th, 2019 |url=https://www.pro-football-reference.com/boxscores/201912150oti.htm |url-status=live |archive-url=https://web.archive.org/web/20191215052838/https://www.pro-football-reference.com/boxscores/201912150oti.htm |archive-date=December 15, 2019 |access-date=January 2, 2020 |work=Pro Football Reference}} Hopkins did not play in Week 17 due to an illness.{{Cite web |last=Gresham |first=Chet |date=December 29, 2019 |title=DeAndre Hopkins active for Week 17, but could get rest |url=https://dknation.draftkings.com/2019/12/29/21041343/deandre-hopkins-texans-status-inactive-week-17-fantasy-football-vs-titans |url-status=live |archive-url=https://web.archive.org/web/20220130185640/https://dknation.draftkings.com/2019/12/29/21041343/deandre-hopkins-texans-status-inactive-week-17-fantasy-football-vs-titans |archive-date=January 30, 2022 |access-date=January 30, 2022 |work=DraftKings Nation}}

Hopkins finished the 2019 season with 104 receptions for 1,165 receiving yards and seven receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2019 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2019/ |url-status=live |archive-url=https://web.archive.org/web/20200111010722/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2019/ |archive-date=January 11, 2020 |access-date=January 2, 2020 |work=Pro Football Reference}} He was ranked 8th by his fellow players on the NFL Top 100 Players of 2020.{{Cite web |title=2020 NFL Top 100 |url=https://www.pro-football-reference.com/awards/2020-nfl-top-100.htm |url-status=live |archive-url=https://web.archive.org/web/20220408124719/https://www.pro-football-reference.com/awards/2020-nfl-top-100.htm |archive-date=April 8, 2022 |access-date=June 18, 2022 |work=Pro Football Reference}}

The Texans finished atop the AFC South with a 10–6 record and qualified for the playoffs.{{Cite web |title=2019 NFL Standings & Team Stats |url=https://www.pro-football-reference.com/years/2019/index.htm |url-status=live |archive-url=https://web.archive.org/web/20220603045242/https://www.pro-football-reference.com/years/2019/index.htm |archive-date=June 3, 2022 |access-date=June 18, 2022 |work=Pro Football Reference}} In the Wild Card Round against the Bills, Hopkins recorded six receptions for 90 receiving yards and a crucial two-point conversion in a 22–19 overtime victory. The two-point conversion put the Texans up 19–16 in regulation. On the Texans' final drive in overtime, Hopkins had a key first down early to set in motion the eventual game-winning field goal.{{Cite web |title=Wild Card – Buffalo Bills at Houston Texans – January 4th, 2020 |url=https://www.pro-football-reference.com/boxscores/202001040htx.htm |url-status=live |archive-url=https://web.archive.org/web/20200101132118/https://www.pro-football-reference.com/boxscores/202001040htx.htm |archive-date=January 1, 2020 |access-date=June 26, 2022 |work=Pro Football Reference}} In the Divisional Round against the Chiefs, he caught nine passes for 118 receiving yards during the 51–31 road loss.{{cite web |title=Chiefs rally from 24–0 hole to beat Texans 51–31 in playoffs |url=https://www.espn.com/nfl/recap?gameId=401131043 |website=ESPN |date=2020-01-12 |archive-url=https://web.archive.org/web/20200306163825/https://www.espn.com/nfl/recap?gameId=401131043 |archive-date=2020-03-06 |url-status=live |access-date=January 12, 2020 |agency=Associated Press}}

File:Cardinals WR DeAndre Hopkins.jpg

On March 16, 2020, the Texans traded Hopkins and a fourth-round pick in the 2020 NFL draft to the Arizona Cardinals for running back David Johnson, a 2020 second-round pick, and a 2021 fourth-round pick.{{cite web |title=Cards get DeAndre Hopkins, ship RB David Johnson to Texans |url=https://www.espn.com/nfl/story/_/id/28911551/cardinals-get-deandre-hopkins-ship-rb-david-johnson-texans |website=ESPN |date=2020-03-16 |archive-url=https://web.archive.org/web/20200317145631/https://www.espn.com/nfl/story/_/id/28911551/cardinals-get-deandre-hopkins-ship-rb-david-johnson-texans |archive-date=2020-03-17 |url-status=live |last1=Barshop |first1=Sarah |access-date=March 18, 2020}}{{cite web |title=DeAndre Hopkins Deal Another Big Trade For Cardinals, Steve Keim |url=https://www.azcardinals.com/news/deandre-hopkins-david-johnson-deal-another-big-trade-for-cardinals-steve-keim |website=Arizona Cardinals |date=2020-03-20 |archive-url=https://web.archive.org/web/20200321145032/https://www.azcardinals.com/news/deandre-hopkins-david-johnson-deal-another-big-trade-for-cardinals-steve-keim |archive-date=2020-03-21 |url-status=live |last1=Urban |first1=Darren |access-date=March 21, 2020}} Reception to the trade was highly critical of the Texans, as well as the head coach at the time, Bill O'Brien, with many sportswriters calling it one of the worst of all time from their perspective, while simultaneously praising the Cardinals for "robbing" the Texans.{{Cite web |last=Harmon |first=Matt |date=March 16, 2020 |title=Houston Texans deal DeAndre Hopkins to Arizona Cardinals: This is the worst trade of all time |url=https://sports.yahoo.com/the-houston-texans-trade-of-de-andre-hopkins-is-the-worst-trade-of-alltime-215411647.html |url-status=live |archive-url=https://web.archive.org/web/20200526091945/https://sports.yahoo.com/the-houston-texans-trade-of-de-andre-hopkins-is-the-worst-trade-of-alltime-215411647.html |archive-date=May 26, 2020 |access-date=May 27, 2020 |work=Yahoo}}{{Cite web |last=Joseph |first=Andrew |date=March 16, 2020 |title=The Texans' trade of DeAndre Hopkins was so bad that it got declined in Madden |url=https://ftw.usatoday.com/2020/03/texans-cardinals-trade-madden-declined-deandre-hopkins-david-johnson-obrien |url-status=live |archive-url=https://web.archive.org/web/20200426134831/https://ftw.usatoday.com/2020/03/texans-cardinals-trade-madden-declined-deandre-hopkins-david-johnson-obrien |archive-date=April 26, 2020 |access-date=May 27, 2020 |work=USA Today |publisher=For the Win}}{{cite web |title=DeAndre Hopkins trade grade: The Texans flunked, and the Cardinals got an elite receiver |url=https://www.espn.com/nfl/story/_/id/28911663/deandre-hopkins-trade-grade-texans-flunked-cardinals-got-elite-receiver |website=ESPN |date=2020-03-16 |archive-url=https://web.archive.org/web/20200527081235/https://www.espn.com/nfl/story/_/id/28911663/deandre-hopkins-trade-grade-texans-flunked-cardinals-got-elite-receiver |archive-date=2020-05-27 |url-status=live |last1=Barnwell |first1=Bill |access-date=May 27, 2020}}

On September 8, 2020, Hopkins signed a two-year, $54.5 million contract extension with the Cardinals.{{Cite web |last=Shook |first=Nick |date=September 8, 2020 |title=Cardinals, DeAndre Hopkins agree to 2-year, $54.5 million extension |url=https://www.nfl.com/news/cardinals-deandre-hopkins-2-year-54-5-million-extension |url-status=live |archive-url=https://web.archive.org/web/20200917173818/https://www.nfl.com/news/cardinals-deandre-hopkins-2-year-54-5-million-extension |archive-date=September 17, 2020 |access-date=September 18, 2020 |website=NFL.com}}

On September 13, 2020, Hopkins made his debut as a Cardinal against the San Francisco 49ers, recording a career-high 14 receptions for 151 yards in the 24–20 win.{{Cite web |title=Arizona Cardinals at San Francisco 49ers – September 13th, 2020 |url=https://www.pro-football-reference.com/boxscores/202009130sfo.htm |url-status=live |archive-url=https://web.archive.org/web/20200922122437/https://www.pro-football-reference.com/boxscores/202009130sfo.htm |archive-date=September 22, 2020 |access-date=September 18, 2020 |work=Pro Football Reference}} In Week 2 against the Washington Football Team, Hopkins caught eight passes for 68 yards and his first receiving touchdown as a Cardinal during the 30–15 win.{{Cite web |title=Washington Football Team at Arizona Cardinals – September 20th, 2020 |url=https://www.pro-football-reference.com/boxscores/202009200crd.htm |url-status=live |archive-url=https://web.archive.org/web/20200818093711/https://www.pro-football-reference.com/boxscores/202009200crd.htm |archive-date=August 18, 2020 |access-date=September 23, 2020 |work=Pro Football Reference}} In Week 3, he recorded ten receptions for 137 receiving yards in the 26–23 loss to the Detroit Lions.{{Cite web |title=Detroit Lions at Arizona Cardinals – September 27th, 2020 |url=https://www.pro-football-reference.com/boxscores/202009270crd.htm |url-status=live |archive-url=https://web.archive.org/web/20200924112916/https://www.pro-football-reference.com/boxscores/202009270crd.htm |archive-date=September 24, 2020 |access-date=September 30, 2020 |work=Pro Football Reference}} In Week 5 against the New York Jets, Hopkins recorded six catches for 131 yards, including a 37-yard touchdown reception, during the 30–10 win.{{Cite web |title=Arizona Cardinals at New York Jets – October 11th, 2020 |url=https://www.pro-football-reference.com/boxscores/202010110nyj.htm |url-status=live |archive-url=https://web.archive.org/web/20201016200917/https://www.pro-football-reference.com/boxscores/202010110nyj.htm |archive-date=October 16, 2020 |access-date=October 11, 2020 |work=Pro Football Reference}} In Week 7 against the Seahawks on Sunday Night Football, Hopkins recorded 10 catches for 103 yards and a touchdown during the 37–34 overtime win.{{Cite web |title=Seattle Seahawks at Arizona Cardinals – October 25th, 2020 |url=https://www.pro-football-reference.com/boxscores/202010250crd.htm |url-status=live |archive-url=https://web.archive.org/web/20201101080738/https://www.pro-football-reference.com/boxscores/202010250crd.htm |archive-date=November 1, 2020 |access-date=October 26, 2020 |work=Pro Football Reference}} In Week 10 against the Bills, Hopkins recorded seven receptions for 127 yards and the game winning touchdown on a 43-yard Hail Mary pass thrown by Kyler Murray with one second left in the 32–30 win which would later be referred to as Hail Murray. Hopkins leaped over three defenders to catch the touchdown.{{cite web |title=Cardinals vs. Bills score: DeAndre Hopkins delivers unbelievable game-winning catch from Kyler Murray |url=https://www.cbssports.com/nfl/news/cardinals-vs-bills-score-deandre-hopkins-delivers-unbelievable-game-winning-catch-from-kyler-murray/live/ |website=CBS Sports |date=2020-11-15 |archive-url=https://web.archive.org/web/20201116005538/https://www.cbssports.com/nfl/news/cardinals-vs-bills-score-deandre-hopkins-delivers-unbelievable-game-winning-catch-from-kyler-murray/live/ |archive-date=2020-11-16 |url-status=live |last1=Walker |first1=Patrik |access-date=November 16, 2020}}{{cite web |title=Arizona Cardinals beat Buffalo Bills on Kyler Murray-to-DeAndre Hopkins Hail Mary |url=https://www.espn.com/nfl/story/_/id/30325839/arizona-cardinal-beat-buffalo-bills-kyler-murray-deandre-hopkins-hail-mary |website=ESPN |date=2020-11-16 |archive-url=https://web.archive.org/web/20201116004730/https://www.espn.com/nfl/story/_/id/30325839/arizona-cardinal-beat-buffalo-bills-kyler-murray-deandre-hopkins-hail-mary |archive-date=2020-11-16 |url-status=live |last1=Weinfuss |first1=Josh |access-date=November 16, 2020}} Hopkins was named the NFC Offensive Player of the Week for his performance.{{Cite web |last=Gordon |first=Grant |date=November 18, 2020 |title=Cardinals WR DeAndre Hopkins, Steelers QB Ben Roethlisberger among Players of the Week |url=https://www.nfl.com/news/deandre-hopkins-ben-roethlisberger-players-of-the-week |url-status=live |archive-url=https://web.archive.org/web/20201118133542/https://www.nfl.com/news/deandre-hopkins-ben-roethlisberger-players-of-the-week |archive-date=November 18, 2020 |access-date=November 18, 2020 |website=NFL.com}}

On November 19, Hopkins became the youngest player to reach 700 catches, a record that was held by his teammate, Larry Fitzgerald,{{Cite web |last=Dunham |first=Torrence |date=November 20, 2020 |title=Hopkins passes teammate Fitzgerald as youngest player to 700 receptions |url=https://arizonasports.com/story/2455032/hopkins-passes-teammate-fitzgerald-as-youngest-player-to-700-receptions/ |url-status=live |archive-url=https://web.archive.org/web/20210109185554/https://arizonasports.com/story/2455032/hopkins-passes-teammate-fitzgerald-as-youngest-player-to-700-receptions/ |archive-date=January 9, 2021 |access-date=November 24, 2020 |work=Arizona Sports}} during the 28–21 loss to Seattle. In Week 14 against the Giants, Hopkins recorded nine receptions for 136 yards during the 26–7 victory.{{Cite web |title=Arizona Cardinals at New York Giants – December 13th, 2020 |url=https://www.pro-football-reference.com/boxscores/202012130nyg.htm |url-status=live |archive-url=https://web.archive.org/web/20201213083939/https://www.pro-football-reference.com/boxscores/202012130nyg.htm |archive-date=December 13, 2020 |access-date=December 18, 2020 |work=Pro Football Reference}} In Week 15 against the Philadelphia Eagles, Hopkins recorded nine catches for 169 yards and a touchdown during the 33–26 win.{{Cite web |title=Philadelphia Eagles at Arizona Cardinals – December 20th, 2020 |url=https://www.pro-football-reference.com/boxscores/202012200crd.htm |url-status=live |archive-url=https://web.archive.org/web/20201219042606/https://www.pro-football-reference.com/boxscores/202012200crd.htm |archive-date=December 19, 2020 |access-date=December 20, 2020 |work=Pro Football Reference}} In Week 17, against the Los Angeles Rams, Hopkins went over 10,000 receiving yards for his career. He became the youngest player in NFL history to eclipse the mark.{{Cite web |date=February 26, 2021 |title=Cardinals WR DeAndre Hopkins laughs at Texans: 'They said I'm only worth a 2nd rounder' |url=https://texanswire.usatoday.com/2021/02/26/deandre-hopkins-laughs-texans-only-worth-2nd-rounder/ |url-status=live |archive-url=https://web.archive.org/web/20210415174206/https://texanswire.usatoday.com/2021/02/26/deandre-hopkins-laughs-texans-only-worth-2nd-rounder/ |archive-date=April 15, 2021 |access-date=June 26, 2022 |work=Texans Wire}} Overall, Hopkins finished the season with 115 receptions for 1,407 receiving yards and six receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2020 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2020/ |url-status=live |archive-url=https://web.archive.org/web/20210707004121/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2020 |archive-date=July 7, 2021 |access-date=January 8, 2021 |work=Pro Football Reference}} His 115 receptions set a new franchise mark for a single season, breaking Fitzgerald's marks in 2015 and 2017.{{Cite web |title=Chicago/St. Louis/Arizona Cardinals Single-Season Receiving Leaders |url=https://www.pro-football-reference.com/teams/crd/single-season-receiving.htm |url-status=live |archive-url=https://web.archive.org/web/20180629000845/https://www.pro-football-reference.com/teams/crd/single-season-receiving.htm |archive-date=June 29, 2018 |access-date=January 8, 2021 |work=Pro Football Reference}} He was ranked 8th by his fellow players on the NFL Top 100 Players of 2021{{Cite web |title=2021 NFL Top 100 |url=https://www.pro-football-reference.com/awards/2021-nfl-top-100.htm |url-status=live |archive-url=https://web.archive.org/web/20211115200023/https://www.pro-football-reference.com/awards/2021-nfl-top-100.htm |archive-date=November 15, 2021 |access-date=June 18, 2022 |work=Pro Football Reference}} and was named to his fifth Pro Bowl.{{cite web |title=Kyler Murray, DeAndre Hopkins, Budda Baker Named To Pro Bowl |url=https://www.azcardinals.com/news/kyler-murray-deandre-hopkins-budda-baker-named-to-pro-bowl |website=Arizona Cardinals |date=2020-12-21 |archive-url=https://web.archive.org/web/20210622111619/https://www.azcardinals.com/news/kyler-murray-deandre-hopkins-budda-baker-named-to-pro-bowl |archive-date=2021-06-22 |url-status=live |last1=Urban |first1=Darren |access-date=June 26, 2022}}

In a Week 1 matchup against the Titans, Hopkins had six receptions for 83 yards and two touchdowns in the 38–13 rout.{{Cite web |title=Arizona Cardinals at Tennessee Titans – September 12th, 2021 |url=https://www.pro-football-reference.com/boxscores/202109120oti.htm |url-status=live |archive-url=https://web.archive.org/web/20220130185732/https://www.pro-football-reference.com/boxscores/202109120oti.htm |archive-date=January 30, 2022 |access-date=January 30, 2022 |work=Pro Football Reference}} On October 24, a Week 7 game against his former team the Texans, Hopkins caught seven passes for 53 yards and a touchdown in the 31–5 win for the eighth straight defeat and a perfect 7–0 record.{{Cite web |title=Houston Texans at Arizona Cardinals – October 24th, 2021 |url=https://www.pro-football-reference.com/boxscores/202110240crd.htm |url-status=live |archive-url=https://web.archive.org/web/20220130185812/https://www.pro-football-reference.com/boxscores/202110240crd.htm |archive-date=January 30, 2022 |access-date=January 30, 2022 |work=Pro Football Reference}} After the Thursday Night Football loss to the Green Bay Packers, 24–21, Hopkins missed the next three weeks with a hamstring injury.{{cite news |title=DeAndre Hopkins forced his way back into game after injury and Kliff Kingsbury wasn't happy |url=https://sports.yahoo.com/de-andre-hopkins-forced-his-way-back-into-game-after-injury-and-kliff-kingsbury-wasnt-happy-141312475.html |date=2021-10-29 |archive-url=https://web.archive.org/web/20220130185856/https://sports.yahoo.com/de-andre-hopkins-forced-his-way-back-into-game-after-injury-and-kliff-kingsbury-wasnt-happy-141312475.html |archive-date=2022-01-30 |url-status=live |work=Yahoo Sports |last1=Cwik |first1=Chris |access-date=January 30, 2022}} In Week 14, he suffered a torn MCL and was placed on injured reserve on December 18.{{cite web |title=DeAndre Hopkins, Robert Alford To IR; Chase Edmonds Activated |url=https://www.azcardinals.com/news/deandre-hopkins-robert-alford-to-ir-chase-edmonds-activated |website=Arizona Cardinals |date=2021-12-18 |archive-url=https://web.archive.org/web/20211219003431/https://www.azcardinals.com/news/deandre-hopkins-robert-alford-to-ir-chase-edmonds-activated |archive-date=2021-12-19 |url-status=live |last1=Urban |first1=Darren |access-date=January 30, 2022}} He finished the season with 42 catches for 572 yards and eight touchdowns in 10 games.{{Cite web |title=DeAndre Hopkins 2021 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2021/ |url-status=live |archive-url=https://web.archive.org/web/20220130185934/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2021/ |archive-date=January 30, 2022 |access-date=January 30, 2022 |work=Pro Football Reference}} He was ranked 37th by his fellow players on the NFL Top 100 Players of 2022.{{Cite web |title=2022 NFL Top 100 |url=https://www.pro-football-reference.com/awards/2022-nfl-top-100.htm |url-status=live |archive-url=https://web.archive.org/web/20221213101426/https://www.pro-football-reference.com/awards/2022-nfl-top-100.htm |archive-date=December 13, 2022 |access-date=January 22, 2023 |work=Pro Football Reference}}

On May 2, 2022, the NFL announced that Hopkins would be suspended for the first six games of the season for a violation of the league's performance-enhancing drugs policy.{{Cite web |last=Baca |first=Michael |date=May 2, 2022 |title=NFL suspending Cardinals WR DeAndre Hopkins six games for violating PED policy |url=https://www.nfl.com/news/nfl-suspending-cardinals-wr-deandre-hopkins-six-games-for-violating-ped-policy |url-status=live |archive-url=https://web.archive.org/web/20220502202200/https://www.nfl.com/news/nfl-suspending-cardinals-wr-deandre-hopkins-six-games-for-violating-ped-policy |archive-date=May 2, 2022 |access-date=May 2, 2022 |website=NFL.com}} Hopkins returned in Week 7 and had ten receptions for 103 yards in the 42–34 victory over the Saints.{{Cite web |title=New Orleans Saints at Arizona Cardinals – October 20th, 2022 |url=https://www.pro-football-reference.com/boxscores/202210200crd.htm |url-status=live |archive-url=https://web.archive.org/web/20221107010000/https://www.pro-football-reference.com/boxscores/202210200crd.htm |archive-date=November 7, 2022 |access-date=November 4, 2022 |work=Pro Football Reference}} In Week 8, he had 12 receptions for 159 yards and one touchdown in the 34–26 loss to the Minnesota Vikings.{{Cite web |title=Arizona Cardinals at Minnesota Vikings – October 30th, 2022 |url=https://www.pro-football-reference.com/boxscores/202210300min.htm |url-status=live |archive-url=https://web.archive.org/web/20221104193428/https://www.pro-football-reference.com/boxscores/202210300min.htm |archive-date=November 4, 2022 |access-date=November 4, 2022 |work=Pro Football Reference}} Hopkins appeared in nine games in the 2022 season. He finished with 64 receptions for 717 receiving yards and three receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2022 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2022/ |url-status=live |archive-url=https://web.archive.org/web/20221215221219/https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2022/ |archive-date=December 15, 2022 |access-date=January 22, 2023 |work=Pro Football Reference}}

On May 26, 2023, Hopkins was released by the Cardinals.{{cite web |title=Cardinals Release DeAndre Hopkins |url=https://www.si.com/nfl/cardinals/news/arizona-cardinals-release-deandre-hopkins |website=Sports Illustrated |date=2023-05-26 |last1=Druin |first1=Donnie |access-date=January 23, 2024}}

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Hopkins signed a two-year contract with the Titans on July 24, 2023.{{cite web |title=Titans Agree to Terms – and Sign – WR DeAndre Hopkins |url=https://www.tennesseetitans.com/news/titans-agree-to-terms-and-sign-wr-deandre-hopkins |website=Tennessee Titans |date=2023-07-24 |last1=Wyatt |first1=Jim |access-date=January 22, 2024}}

In Week 5 of the 2023 season, Hopkins had eight receptions for 140 yards in a loss to the Colts.{{Cite web |title=Tennessee Titans at Indianapolis Colts – October 8th, 2023 |url=https://www.pro-football-reference.com/boxscores/202310080clt.htm |access-date=January 22, 2024 |work=Pro Football Reference}} In the Week 8 win over the Atlanta Falcons, Hopkins caught his first touchdowns with the team from rookie quarterback, Will Levis, with Hopkins finishing with three receiving touchdowns (the first three-touchdown performance from a single Titans receiver since 2010) and 128 receiving yards.{{cite web |title=Rookie Will Levis throws 4 TDs in his NFL debut as Titans beat Falcons 28–23 |url=https://www.espn.com/nfl/recap/_/gameId/401547500 |website=ESPN |date=2023-10-29 |access-date=December 15, 2023 |agency=Associated Press}} In Week 14, a victory over the Dolphins, he had seven receptions for 124 yards and a touchdown.{{Cite web |last=Suss |first=Nick |date=December 15, 2023 |title=Titans WR DeAndre Hopkins shares thoughts on facing the Houston Texans, his former team |url=https://www.tennessean.com/story/sports/nfl/titans/2023/12/15/deandre-hopkins-tennessee-titans-wr-houston-texans-reunion-injury-update/71885677007/ |access-date=January 23, 2024 |work=The Tennessean}} He finished the 2023 season with 75 receptions for 1,057 receiving yards and seven receiving touchdowns.{{Cite web |title=DeAndre Hopkins 2023 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2023/ |access-date=January 22, 2024 |work=Pro Football Reference}}

Hopkins played in six games for the Titans in 2024, catching 15 passes for 173 yards and a touchdown.{{cite news |title=Five Things to Know About New Chiefs WR DeAndre Hopkins |url=https://www.chiefs.com/news/five-things-to-know-about-new-chiefs-wr-deandre-hopkins |date=2024-10-24 |work=Kansas City Chiefs |last1=McMullen |first1=Matt |access-date=October 28, 2024}}

On October 24, 2024, the Titans traded Hopkins to the Kansas City Chiefs for a 2025 conditional fifth-round pick that would have become a fourth-round pick if Kansas City are to advance to Super Bowl LIX and Hopkins were to play in 60% of the snaps, however, since Hopkins played in less than 50% of the snaps, the pick remained a fifth-round pick.{{cite news |title=It's Official: Titans Trade WR DeAndre Hopkins to the Chiefs in Exchange for Conditional 5th Round Draft Pick |url=https://www.tennesseetitans.com/news/it-s-official-titans-trade-wr-deandre-hopkins-to-the-chiefs-in-exchange-for-conditional-5th-round-draft-pick |date=2024-10-24 |work=Tennessee Titans |last1=Wyatt |first1=Jim |access-date=October 24, 2024}}

Three days after being traded, Hopkins made his Chiefs debut on October 27 against the Las Vegas Raiders, catching two passes for 29 yards.{{cite news |last=Skretta |first=Dave |title=DeAndre Hopkins makes promising debut as Chiefs run win streak to 13 straight by beating the Raiders |url=https://apnews.com/article/kansas-city-chiefs-nfl-18eea570c61190c37c1272c02c07eb1f |access-date=November 4, 2024 |work=Associated Press |date=October 28, 2024}} In his second game, Hopkins finished with 86 yards and scored two touchdowns in an overtime win over the Tampa Bay Buccaneers.{{cite news |last1=Teicher |first1=Adam |last2=Laine |first2=Jenna |title=Chiefs survive OT, Mahomes injury scare to beat Bucs |url=https://www.espn.com/nfl/story/_/id/42199598/chiefs-hold-ot-win-buccaneers |access-date=November 4, 2024 |work=ESPN |date=November 4, 2024}} In the 2024 season, Hopkins finished with 56 receptions for 610 yards and five touchdowns.{{cite web |title=DeAndre Hopkins 2024 Game Log |url=https://www.pro-football-reference.com/players/H/HopkDe00/gamelog/2024/ |website=Pro Football Reference |access-date=2025-01-21 |language=en}} He reached the Super Bowl for the first time in his career, scoring a touchdown and a two-point conversion in the 40–22 loss to the Philadelphia Eagles.{{cite web |title=Eagles deny the Chiefs a Super Bowl three-peat with dominant defense in a 40-22 rout |url=https://apnews.com/article/super-bowl-2025-eagles-chiefs-score-e2ff209c074a00a6faff39750ff048f8 |website=Associated Press |date=2025-02-10 |last1=Maaddi |first1=Rob |access-date=2025-02-11}} He became the second wide receiver in Super Bowl history to have a receiving touchdown and a two-point conversion in one game.{{Cite web |title=Players with a touchdown and a two-point conversion in the same Super Bowl, NFL history |url=https://www.statmuse.com/nfl/ask/players-with-a-touchdown-and-two-point-conversion-in-the-super-bowl |access-date=2025-02-18 |website=StatMuse |language=en}}

On March 13, 2025, Hopkins signed a one-year, $5 million contract with the Baltimore Ravens.{{cite news |title=DeAndre Hopkins And Ravens Agree to Contract Terms |url=https://www.baltimoreravens.com/news/deandre-hopkins-reports-ravens-reaches-agreement |date=2025-03-13 |archive-url=https://web.archive.org/web/20250313183525/https://www.baltimoreravens.com/news/deandre-hopkins-reports-ravens-reaches-agreement |archive-date=2025-03-13 |url-status=live |work=Baltimore Ravens |last1=Brown |first1=Clifton |access-date=13 March 2025 |df=mdy-all |language=en}}

• Receiving yards in a single postseason: 208 (2019){{Cite web |title=Most receiving yards in a single postseason, Houston Texans |url=https://www.statmuse.com/nfl/ask?q=player+with+the+most+receiving+yards+in+a+single+postseason%252c+texans |url-status=live |archive-url=https://web.archive.org/web/20220626201958/https://www.statmuse.com/nfl/ask?q=player+with+the+most+receiving+yards+in+a+single+postseason%252c+texans |archive-date=June 26, 2022 |access-date=June 26, 2022 |website=StatMuse |language=en}}
• Receptions in a season: 115 (2018){{Cite web |title=Houston Texans Single-Season Receiving Leaders |url=https://www.pro-football-reference.com/teams/htx/single-season-receiving.htm |url-status=live |archive-url=https://web.archive.org/web/20211125163427/https://www.pro-football-reference.com/teams/htx/single-season-receiving.htm |archive-date=November 25, 2021 |access-date=June 26, 2022 |website=Pro Football Reference |language=en}}
• Receiving touchdowns in a season: 13 (2017)

File:DeAndre Hopkins Gym.png

Hopkins' father died in a car accident when Hopkins was five months old, leaving his mother to raise him and his three siblings as a single mother. Hopkins credits his success to his mother, Sabrina Greenlee.{{Cite web |date=May 9, 2015 |title=NFL Star DeAndre Hopkins: 'I Have An UnBreakable Relationship With My Mom' |url=https://www.yahoo.com/amphtml/parenting/nfl-star-deandre-hopkins-i-have-an-unbreakable-118463107107.html |url-status=live |archive-url=https://web.archive.org/web/20190430040106/https://www.yahoo.com/amphtml/parenting/nfl-star-deandre-hopkins-i-have-an-unbreakable-118463107107.html |archive-date=April 30, 2019 |access-date=October 11, 2018 |website=Yahoo! |language=en}}

In July 2002, Greenlee had a boiling concoction of lye and bleach thrown at her face by a woman her boyfriend had an affair with. The attack resulted in the skin rapidly peeling off her neck, face, and back and left her blind. Because of her inability to watch him play due to blindness, Hopkins started a tradition of giving touchdown balls to her immediately after scoring in an effort to remain close to her.{{Cite web |last=Boucher |first=Ashley |date=November 22, 2019 |title=Wide Receiver DeAndre Hopkins Gives His Mom, Who Is Blind, Touchdown Ball in Sweet Game Tradition |url=https://people.com/sports/deandre-hopkins-gives-blind-mom-touchdown-ball/ |access-date=2024-06-18 |website=People}}{{Cite web |last=Weisholtz |first=Drew |date=November 22, 2019 |title=NFL star has touching touchdown tradition with mother blinded in acid attack |url=https://www.today.com/parents/deandre-hopkins-has-tradition-mom-after-scoring-touchdown-t168095 |access-date=2024-06-18 |website=TODAY.com}}

Hopkins' uncle on his mother's side, Terry Smith, played wide receiver at Clemson and went undrafted before having a brief professional career.{{cite web |title=Hale: Florida State's Terrance Smith holds on to the memory of a father he barely knew |url=https://www.espn.com/college-football/story/_/id/9843347/florida-state-seminoles-linebacker-terrance-smith-not-ashamed-father-name |website=ESPN |date=2013-10-24 |last1=Hale |first1=David |access-date=2024-06-18 |language=en}}

Hopkins is a Christian. He grew up going to church with his mother and was baptized one day after practice at Clemson in 2012. Hopkins has said, "My faith is a big, big thing for me. It is a major part of my life."

"No matter how hard life can get, you can never give up. Just work hard, live right, and have faith in the Lord."{{Cite web |last=Duduit |first=Del |date=September 22, 2020 |title=DeAndre Hopkins Never Gives Up |url=https://www.athletesinaction.org/articles/deandre-hopkins-never-gives-up/ |url-status=live |archive-url=https://web.archive.org/web/20210111054027/https://athletesinaction.org/articles/deandre-hopkins-never-gives-up/ |archive-date=January 11, 2021 |access-date=November 19, 2020 |website=Athletes In Action}}

During his time at Clemson, Hopkins majored in community recreation and sport & camp management.{{Cite web |last=Payne |first=Scotty |date=March 1, 2013 |title=2013 Draft Prospects: WR DeAndre Hopkins |url=https://www.milehighreport.com/2013/3/1/4041498/2013-nfl-draft-prospects-wr-deandre-hopkins-scouting-profile-denver-broncos |url-status=live |archive-url=https://web.archive.org/web/20160502174234/http://www.milehighreport.com/2013/3/1/4041498/2013-nfl-draft-prospects-wr-deandre-hopkins-scouting-profile-denver-broncos |archive-date=May 2, 2016 |access-date=February 2, 2021 |website=Mile High Report |language=en}}

Hopkins holds a SMOOOTH Back-to-school giveaway that supplies book bags and school supplies for over 2,500 children. SMOOOTH is an acronym that stands for "Speaking Mentally Outwardly Opening Opportunities Towards Healing".{{Cite web |date=July 26, 2014 |title=DeAndre Hopkins partners with S.M.O.O.T.H. to help school children |url=https://www.wyff4.com/article/deandre-hopkins-partners-with-smooth-to-help-school-children/6762280 |archive-url=https://web.archive.org/web/20190225103112/https://www.wyff4.com/article/deandre-hopkins-partners-with-smooth-to-help-school-children/6762280 |archive-date=February 25, 2019 |access-date=February 24, 2019 |website=NBC – WYFF4 |language=en}} In 2021, Hopkins went into the cereal business with "DeAndre's Hop Box". A portion of the proceeds of the cereal's sales went to the SMOOOTH Foundation.{{Cite web |last=Cluff |first=Jeremy |date=May 11, 2021 |title=DeAndre Hopkins cereal to benefit domestic violence survivors now available in Arizona |url=https://www.azcentral.com/story/sports/nfl/cardinals/2021/05/11/arizona-cardinals-deandre-hopkins-launching-cereal-benefit-charity/5037844001/ |url-status=live |archive-url=https://web.archive.org/web/20230122051300/https://www.azcentral.com/story/sports/nfl/cardinals/2021/05/11/arizona-cardinals-deandre-hopkins-launching-cereal-benefit-charity/5037844001/ |archive-date=January 22, 2023 |access-date=June 28, 2022 |website=The Arizona Republic |language=en-US}}

In March 2020, Hopkins partnered with Beyond Meat. The partnership started the Feed A Million+ pledge with the intent to donate and distribute more than one million Beyond Burgers across the United States to needy people.{{Cite web |last=Devadanam |first=Steven |date=April 24, 2020 |title=Former Houston Texans superstar serves up meatless burgers to locals in need |url=https://houston.culturemap.com/news/city-life/04-24-20-deandre-hopkins-beyond-meat-houston-burgers-sports-illustrated-bill-obrien/ |url-status=live |archive-url=https://web.archive.org/web/20220625174708/https://houston.culturemap.com/news/city-life/04-24-20-deandre-hopkins-beyond-meat-houston-burgers-sports-illustrated-bill-obrien/ |archive-date=June 25, 2022 |access-date=June 28, 2022 |website=CultureMap Houston |language=en}}

In 2020, Hopkins displayed the name of Denmark Vesey on his helmet as a tribute to the alleged mastermind of a thwarted 1822 South Carolina slave revolt. Hopkins chose Vesey due to their South Carolina heritage, to honor Vesey's sacrifice for equality, and to draw attention to a history that is not commonly taught.{{cite web |title=Why Cardinals' DeAndre Hopkins honors Denmark Vesey on his helmet |url=https://www.espn.com/blog/arizona-cardinals/post/_/id/33683/why-deandre-hopkins-honors-denmark-vesey-on-his-helmet |website=ESPN |date=2020-10-21 |archive-url=https://web.archive.org/web/20220504131823/https://www.espn.com/blog/arizona-cardinals/post/_/id/33683/why-deandre-hopkins-honors-denmark-vesey-on-his-helmet |archive-date=2022-05-04 |url-status=live |last1=Weinfuss |first1=Josh |access-date=May 4, 2022 |language=en}}

{{Reflist}}

{{Commons}}

• [https://www.baltimoreravens.com/team/players-roster/deandre-hopkins/ Baltimore Ravens bio]
• [https://web.archive.org/web/20131230232920/http://www.clemsontigers.com/ViewArticle.dbml?SPSID=657772&SPID=103701&DB_LANG=C&DB_OEM_ID=28500&ATCLID=205529373&Q_SEASON=2012 Clemson Tigers bio]
• {{Footballstats |nfl=deandre-hopkins|espn=15795|yahoo=26650|cbs=1737078/deandre-hopkins/|pfr=H/HopkDe00}}

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Category:1992 births

Category:Living people

Category:21st-century African-American sportsmen

Category:American Conference Pro Bowl players

Category:American football wide receivers

Category:American men's basketball players

Category:Arizona Cardinals players

Category:Baltimore Ravens players

Category:Basketball players from South Carolina

Category:Clemson Tigers football players

Category:Clemson Tigers men's basketball players

Category:Houston Texans players

Category:Kansas City Chiefs players

Category:National Conference Pro Bowl players

Category:People from Central, South Carolina

Category:Players of American football from South Carolina

Category:Tennessee Titans players

Category:Unconferenced Pro Bowl players

Category:21st-century American sportsmen