Dean H. Kedes

Kedes was born in 1960 to Shirley and Laurence H. Kedes. He earned a BS in biology from Stanford University where he conducted neurobiology research under Eric Shooter. Following completion of his undergraduate degree, Kedes matriculated into the MD-PhD track at Yale University School of Medicine, obtaining his dual degrees in 1988. His thesis was on pre-mRNA splicing completed under Joan A. Steitz. Kedes returned to Stanford University to do a residency in internal medicine from 1988-1991. In 1992 he completed an infectious disease fellowship at University of California San Francisco. From 1993-1996 he held a post doctoral position under Donald Ganem where he was awarded a Howard Hughes Medical Institute Post-doctoral Physician Scientist fellowship.{{cite web|author=Center for Oral History| title= Dean H. Kedes |url=https://oh.sciencehistory.org/oral-histories/kedes-dean-h|website= Science History Institute }}{{cite book|first=David J. |last=Caruso|title=Dean H. Kedes, Transcript of an Interview Conducted by David J. Caruso at University of Virginia on 25 and 26 October 2007 |date=26 October 2007 |url=https://oh.sciencehistory.org/sites/default/files/kedes_dh_0384_suppl.pdf|place=Philadelphia, PA|publisher=Chemical Heritage Foundation }}{{cite web|title=Researchers Find a Herpes Virus That Has a Role in an AIDS-Related Cancer|url=http://www.hhmi.org/news/researchers-find-herpes-virus-has-role-aids-related-cancer|website=Howard Hughes Medical Institute|date=March 1, 1996}}

Kedes was recruited to the University of Virginia in 1999. He was promoted to associate professor in 2004 and full professor in 2015. He is currently a professor in the Department of Microbiology, Immunology, and Cancer Biology as well as in Medicine, Division of Infectious Diseases and International Health.{{Cite web|url=http://www.dailyprogress.com/news/uva-theft-highlights-security-concerns/article_19f5e7cb-a1c9-5395-b8b9-4a896656d24f.html|title = UVa theft highlights security concerns| date=28 April 2008 }} In 2014 he was selected to head the university's medical scientist training program following the 16-year tenure of previous director Gary K. Owens.{{Cite web|url=https://medstro.com/groups/nejm-group-open-forum/discussions/165/featured_guests|title = Featured Guests | NEJM CareerCenter Conversations: Successful}}

Kedes' lab focuses on the pathogenesis of Kaposi's sarcoma-associated herpesvirus, including isolation and characterization of viral genes and their protein products; determination of the protein composition, spatial arrangement and assembly of viral and subviral particles; identification of the cell types initially infected during primary transmission in humans; and the connection between viral and human genomes during chronic infection.{{Cite web|url=http://bims.virginia.edu/faculty/dean-h-kedes/|title = Biomedical Sciences Graduate Program - University of Virginia School of Medicine}}

Kedes has received a Doris Duke Clinical Scientist Award,{{Cite web|url=http://www.ddcf.org/grants/Grant-Recipients/2000-Clinical-Scientist-Development-Award/|title = 2000 Clinical Scientist Development Award}} a Pew Scholarship in the Biomedical Sciences,{{Cite web|url=http://www.pewtrusts.org/en/projects/pew-biomedical-scholars/directory-of-pew-scholars/2000/dean-kedes|title=Dean H. Kedes, M.D., Ph.D.}} and the Elizabeth Glaser Pediatric AIDS Basic Science Award. His work has been supported by grants from the National Institutes of Health since 2000.{{Cite web|url=https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=13E0CF034D89C1D07598B8961CAA4A01A2FFCEB861BF|title=RePORT ⟩ RePORTER}}

• Renne R, Zhong W, Herndier B, et al. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nature Medicine. 1996;2(3):342-346.
• Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nature Medicine. 1996;2(8):918-924.
• Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH. Sexual Transmission and the Natural History of Human Herpesvirus 8 Infection. New England Journal of Medicine. 1998;338(14):948-954.
• Parsons CH, Adang LA, Overdevest J, et al. KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice. Journal of Clinical Investigation. 2006;116(7):1963-1973.
• Adang LA, Parsons CH, Kedes DH. Asynchronous Progression through the Lytic Cascade and Variations in Intracellular Viral Loads Revealed by High-Throughput Single-Cell Analysis of Kaposi's Sarcoma-Associated Herpesvirus Infection. Journal of Virology. 2006;80(20):10073-10082.
• Hassman, L.H., Ellison, T.J., Kedes, D.H. KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. Journal of Clinical Investigation. 2011, 121(2): 752–768 {{PMID|21245574}}.
• Woodson, E.N., Anderson, M.A., Loftus, M.S., and Kedes, D.H. Progressive accumulation of activated ERK2 within highly stable ORF45-containing nuclear complexes promotes lytic gammaherpesvirus infection 2014 PLoS Pathogen. 10(4): e1004066.

• UVa MSTP

{{reflist|30em}}

• [http://bims.virginia.edu/faculty/dean-h-kedes/ UVa Faculty Page: Kedes]
• [https://mstp.med.virginia.edu/ UVa MSTP home page]

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Category:1960 births

Category:Living people

Category:Stanford University alumni

Category:University of Virginia School of Medicine faculty

Category:Yale School of Medicine alumni

Category:American virologists