Debbie C. Crans
{{Short description|Professor of chemistry}}
{{infobox academic
|name= Debbie Catharina Crans
|image= File:DebbieCrans2015.jpg|alt=
| birth_date = {{Birth date and age|1955|8|13|mf=y}}{{cite web|url=http://wp.natsci.colostate.edu/crans/crans-brief-resume/|title=Crans Brief Resume|last=Crans|first=Debbie C.|accessdate=24 August 2016}}
|doctoral_advisor= George M. Whitesides
|workplaces= {{ublist |University of California, Los Angeles (1985–1986) |Colorado State University 1987–present }}
|website= {{url|https://wp.natsci.colostate.edu/crans/}}
|thesis_title=Methodology in Enzyme-Catalyzed Organic Synthesis: Glycerol Kinase Catalyzed Phosphorylations|thesis_url=https://www.proquest.com/pqdtglobal/docview/303340659/88D0B3568CF74741PQ|thesis_year=1985|caption=Debbie Crans after receiving her 2015 Cope Scholar Award|alma_mater=Harvard University (Ph.D. 1985)
University of Copenhagen (B.S. 1978)|academic_advisors=James P. Snyder, Paul von Ragué Schleyer, Orville L. Chapman, Paul D. Boyer}}
Debbie C. Crans is a Professor of Organic, Inorganic and Biological Chemistry and of Cell and Molecular Biology at Colorado State University,{{Cite web|title=Debbie Crans {{!}} CWGE {{!}} Colorado State University|url=https://cwge.colostate.edu/debbie-crans/|access-date=2021-05-31|language=en-US}} where she also is a Professor Laureate of the College of Natural Sciences. Crans specializes in the fundamental chemistry and biochemistry of drugs, with particular focus on vanadium and other transition metal ions as metals in medicine and investigation of their mechanisms of toxicity.
Education
Debbie Crans studied at the University of Copenhagen, studying for her Cand. Scient. 1. part (B.S.) in 1974–1978, then her Cand. Scient. 2. part (research) in 1978–1980. During this time, she worked with Prof. James P. Snyder at Copenhagen, and Prof. Paul von Ragué Schleyer at the University of Erlangen–Nuremberg in Germany on computational studies of free radicals.{{Cite journal|last1=Crans|first1=Debbie C.|last2=Snyder|first2=James P.|date=1980|title=Tetracoordinate planar carbon: a singlet biradical|url=https://pubs.acs.org/doi/pdf/10.1021/ja00543a066|journal=Journal of the American Chemical Society|volume=102|issue=23|pages=7152–7154|doi=10.1021/ja00543a066|issn=0002-7863}}{{Cite journal|last1=Crans|first1=Debbie C.|last2=Snyder|first2=James P.|date=1980|title=cis- and trans-Azoalkanes: Force field determination of molecular structures, heats of formation, and strain energies|url=https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cber.19801130342|journal=Chemische Berichte|language=de|volume=113|issue=3|pages=1201–1204|doi=10.1002/cber.19801130342|issn=1099-0682}}{{Cite journal|date=1980-01-01|title=A theoretical evaluation of the synergetic capto-dative stabilisation of free radicals|url=https://www.sciencedirect.com/science/article/abs/pii/S0040403900787442|journal=Tetrahedron Letters|language=en|volume=21|issue=38|pages=3681–3684|doi=10.1016/S0040-4039(00)78744-2|issn=0040-4039|last1=Crans |first1=Debbie |last2=Clark |first2=Timothy |last3=von Ragué Schleyer |first3=Paul }} She then moved to Harvard University in the United States to pursue graduate studies in the laboratory of Prof. George M. Whitesides. At Harvard, Crans worked on enzyme-catalyzed phosphorylation reactions, using glycerol kinase to synthesize chiral analogs of glycerol.{{Cite journal|last1=Crans|first1=Debbie C.|last2=Whitesides|first2=George M.|date=1985|title=Glycerol kinase: synthesis of dihydroxyacetone phosphate, sn-glycerol-3-phosphate, and chiral analogs|url=https://pubs.acs.org/doi/pdf/10.1021/ja00310a045|journal=Journal of the American Chemical Society|volume=107|issue=24|pages=7019–7027|doi=10.1021/ja00310a045|issn=0002-7863}}{{Cite journal|last1=Crans|first1=Debbie C.|last2=Whitesides|first2=George M.|date=1985|title=Glycerol kinase: substrate specificity|url=https://pubs.acs.org/doi/pdf/10.1021/ja00310a044|journal=Journal of the American Chemical Society|volume=107|issue=24|pages=7008–7018|doi=10.1021/ja00310a044|issn=0002-7863}} She graduated with her Ph.D. in 1985. She went on to do postdoctoral work with Orville L. Chapman and Paul D. Boyer at the University of California, Los Angeles from 1985 to 1986, studying the mechanistic enzymology of the F1 subunit of ATP synthase from chloroplasts and beef heart.{{Cite web|last=Tullo|first=Alex|date=March 9, 2015|title=Arthur C. Cope Scholar Awards|url=https://cen.acs.org/articles/93/i10/Arthur-C-Cope-Scholar-Awards.html?type=paidArticleContent|url-status=live|access-date=2021-05-31|website=cen.acs.org|archive-url=https://web.archive.org/web/20150820021858/http://cen.acs.org:80/articles/93/i10/Arthur-C-Cope-Scholar-Awards.html?type=paidArticleContent |archive-date=2015-08-20 }}
Independent career and research
Crans began her independent career as an assistant professor at Colorado State University in 1987. She was promoted to associate professor in 1991, and full professor in 1998.
Crans is known for her work on the role of vanadium in biological systems, especially the effects of its compounds on diabetes. She has worked as senior editor several books on vanadium, such as Vanadium Compounds: Chemistry, Biochemistry, and Therapeutic Applications,{{cite book|title=Vanadium Compounds: Chemistry, Biochemistry, and Therapeutic Applications|editor=Tracy, Alan S. |editor2=Crans, Debbie C.|publisher=American Chemical Society|location=Washington, DC|date=1998|series=ACS Symposium Series|url=http://pubs.acs.org/isbn/0841235899|language=English}} Vanadium: The Versatile Metal{{cite book|title=Vanadium: The Versatile Metal|editor=Kustin, Kenneth |editor2=Pessoa, João Costa |editor3=Crans, Debbie C.|publisher=American Chemical Society|location=Washington, DC|date=2007|series=ACS Symposium Series|url=http://pubs.acs.org/isbn/9780841274464|language=English}} and Vanadium in Biochemistry.{{cite book|last=Crans|first= Debbie C.|author2=Simone, Carmen |title=Vanadium in Biochemistry|publisher=Wiley|location=Hoboken, NJ|date=2013|url=http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471242454.html|language=English}} Crans served as chair of the American Chemical Society in 2015 and 2016. She has also been associate editor for the New Journal of Chemistry, Inorganic Chemistry, the Journal of Inorganic Biochemistry and Coordination Chemistry Reviews.Crans, Debbie. Circulum Vitae.
Crans has contributed to over 215 peer-reviewed articles. As of spring 2019, her work has been cited 7,200 times excluding self-citations making her h-index of 53. Her review paper, "The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds" has been cited over 900 times.{{Cite journal|last=Crans|first=Debbie C|date=2004|title=The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds|journal=Chemical Reviews|volume=104|issue=2 |pages=849–902|doi=10.1021/cr020607t|pmid=14871144 }} Her study on "Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats"{{cite journal|last=Crans|first=Debbie C.|date=30 May 2000|title=Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds|journal=Journal of Inorganic Biochemistry|language=English|volume=80|issue=1–2|pages=123–131|doi=10.1016/s0162-0134(00)00048-9|pmid=10885472}} describes the use of vanadium compounds as hypoglycemic agents, and it has been widely cited.{{cite web|title=Chemistry and insulin-like properties of vanadium (IV) and vanadium (V) compounds|url=https://scholar.google.com/scholar?cites=2962849610312876286&as_sdt=5,39&sciodt=0,39&hl=en|publisher=Google Scholar|language=English|accessdate=24 August 2016}}
Awards
= International Awards =
- 2019 ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry{{Cite web|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/recipients/2019-national-award-recipients-citations.html|title=2019 National Award Recipients Citations|website=American Chemical Society|language=en|access-date=2019-05-09}}
- 2015 Arthur C. Cope Scholar Award
- 2012 Lectureship award, Japanese Coordination Chemistry Society
- 2004 Vanadis award from the International Vanadium Symposium in Szeged
- 2000 Japan Society of Promotion of Science award
- 2000 Alexander Humboldt Senior Research awardee
= National Awards =
- 2017 ChemLuminary Awards Young Chemists Committee{{Cite web|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/community/what_are_the_chemluminary_awards/2017-chemluminary-award-winners.html|title=2017 ChemLuminary Award Winners|website=American Chemical Society|language=en|access-date=2019-05-09}}
- 2016 Royal Society Fellow
- 2014 AAAS Fellow{{Cite web|url=https://www.aaas.org/fellows/listing|title=Elected Fellows|website=American Association for the Advancement of Science|language=en|access-date=2019-05-09}}
- 2009 ACS Fellow{{Cite web|url=https://www.acs.org/content/acs/en/funding-and-awards/fellows.html|title=ACS Fellows Program|website=American Chemical Society|language=en|access-date=2019-05-09}}
- 1993-96 Alfred P. Sloan Research Fellow{{Cite web|url=https://sloan.org/past-fellows|title=Past Fellows|website=sloan.org|access-date=2019-05-09|archive-date=2018-03-14|archive-url=https://web.archive.org/web/20180314000756/https://sloan.org/past-fellows|url-status=dead}}
- 1994 Alberta Heritage Foundation award
- 1990-1992 Eli Lilly Young Investigator Award
- 1989-1994 National Institutes of Health FIRST award
Personal life
She currently resides in Northern Colorado with her husband and three daughters. One daughter is pursuing the PhD in chemistry at Northwestern University, one is an undergraduate student at Colorado State University, and one works as a financial planner.
References
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Category:Danish women chemists
Category:American women chemists
Category:Bioinorganic chemists
Category:Harvard University alumni
Category:Danish emigrants to the United States
Category:Colorado State University faculty
Category:University of Copenhagen alumni
Category:Place of birth missing (living people)