Decoy receptor 3

Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.

The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.

TNFRSF6B has been shown to interact with:

• TNFSF14{{cite journal |vauthors=Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J | title = Modulation of T-cell responses to alloantigens by TR6/DcR3 | journal = J. Clin. Invest. | volume = 107 | issue = 11 | pages = 1459–68 |date=June 2001 | pmid = 11390428 | pmc = 209323 | doi = 10.1172/JCI12159 }}{{cite journal |vauthors=Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL | title = Modulation of dendritic cell differentiation and maturation by decoy receptor 3 | journal = J. Immunol. | volume = 168 | issue = 10 | pages = 4846–53 |date=May 2002 | pmid = 11994433 | doi = 10.4049/jimmunol.168.10.4846| doi-access = free }}
• Fas ligand.

{{reflist}}

{{refbegin | 2}}

• {{cite journal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 |display-authors=3 |author1=Kikuno R |author2=Nagase T |author3=Ishikawa K |name-list-style=vanc |last4=Hirosawa |first4=M |last5=Miyajima |first5=N |last6=Tanaka |first6=A |last7=Kotani |first7=H |last8=Nomura |first8=N |last9=Ohara |first9=O |doi-access=free }}
• {{cite journal |title=Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 3 |pages= 1230–5 |year= 2000 |pmid= 10655513 |doi=10.1073/pnas.97.3.1230 |display-authors=3 |author1=Bai C |author2=Connolly B |author3=Metzker ML |name-list-style=vanc |last4=Hilliard |first4=CA |last5=Liu |first5=X |last6=Sandig |first6=V |last7=Soderman |first7=A |last8=Galloway |first8=SM |last9=Liu |first9=Q |pmc=15578 |bibcode=2000PNAS...97.1230B |doi-access=free }}
• {{cite journal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=3 |author1=Deloukas P |author2=Matthews LH |author3=Ashurst J |name-list-style=vanc |last4=Burton |first4=J |last5=Gilbert |first5=JG |last6=Jones |first6=M |last7=Stavrides |first7=G |last8=Almeida |first8=JP |last9=Babbage |first9=AK |bibcode=2001Natur.414..865D |doi-access=free }}
• {{cite journal |title=TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator |journal=Immunity |volume=16 |issue= 3 |pages= 479–92 |year= 2002 |pmid= 11911831 |doi=10.1016/S1074-7613(02)00283-2 |display-authors=3 |author1=Migone TS |author2=Zhang J |author3=Luo X |name-list-style=vanc |last4=Zhuang |first4=L |last5=Chen |first5=C |last6=Hu |first6=B |last7=Hong |first7=JS |last8=Perry |first8=JW |last9=Chen |first9=SF |doi-access=free }}
• {{cite journal |title=Modulation of dendritic cell differentiation and maturation by decoy receptor 3 |journal=J. Immunol. |volume=168 |issue= 10 |pages= 4846–53 |year= 2002 |pmid= 11994433 |doi= 10.4049/jimmunol.168.10.4846|display-authors=3 |author1=Hsu TL |author2=Chang YC |author3=Chen SJ |name-list-style=vanc |last4=Liu |first4=YJ |last5=Chiu |first5=AW |last6=Chio |first6=CC |last7=Chen |first7=L |last8=Hsieh |first8=SL |doi-access=free }}
• {{cite journal |title=DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer |journal=Int. J. Cancer |volume=102 |issue= 3 |pages= 254–7 |year= 2002 |pmid= 12397645 |doi= 10.1002/ijc.10711 |display-authors=3 |author1=Mild G |author2=Bachmann F |author3=Boulay JL |name-list-style=vanc |last4=Glatz |first4=K |last5=Laffer |first5=U |last6=Lowy |first6=A |last7=Metzger |first7=U |last8=Reuter |first8=J |last9=Terracciano |first9=L |s2cid=23680078 }}
• {{cite journal |title=Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes |journal=Am. J. Pathol. |volume=161 |issue= 6 |pages= 2011–7 |year= 2003 |pmid= 12466117 |doi= 10.1016/S0002-9440(10)64479-3|author1=Gill RM |author2=Ni J |author3=Hunt JS |pmc=1850908}}
• {{cite journal |title=A TNF family member LIGHT transduces costimulatory signals into human T cells |journal=J. Immunol. |volume=169 |issue= 12 |pages= 6813–21 |year= 2003 |pmid= 12471113 |doi= 10.4049/jimmunol.169.12.6813|display-authors=3 |author1=Wan X |author2=Zhang J |author3=Luo H |name-list-style=vanc |last4=Shi |first4=G |last5=Kapnik |first5=E |last6=Kim |first6=S |last7=Kanakaraj |first7=P |last8=Wu |first8=J |doi-access=free }}
• {{cite journal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |display-authors=3 |author1=Strausberg RL |author2=Feingold EA |author3=Grouse LH |name-list-style=vanc |last4=Derge |first4=JG |last5=Klausner |first5=RD |last6=Collins |first6=FS |last7=Wagner |first7=L |last8=Shenmen |first8=CM |last9=Schuler |first9=GD |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |title=DcR3/TR6 modulates immune cell interactions |journal=J. Cell. Biochem. |volume=89 |issue= 3 |pages= 603–12 |year= 2003 |pmid= 12761893 |doi= 10.1002/jcb.10523 |display-authors=3 |author1=Wan X |author2=Shi G |author3=Semenuk M |name-list-style=vanc |last4=Zhang |first4=J |last5=Wu |first5=J |s2cid=39322989 }}
• {{cite journal |title=Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma |journal=Int. J. Cancer |volume=106 |issue= 1 |pages= 17–25 |year= 2003 |pmid= 12794752 |doi= 10.1002/ijc.11170 |display-authors=3 |author1=Tsuji S |author2=Hosotani R |author3=Yonehara S |name-list-style=vanc |last4=Masui |first4=T |last5=Tulachan |first5=SS |last6=Nakajima |first6=S |last7=Kobayashi |first7=H |last8=Koizumi |first8=M |last9=Toyoda |first9=E |url=https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/148465/1/yigak02633.pdf |hdl=2433/148465 |s2cid=34900944 |doi-access=free }}
• {{cite journal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |display-authors=3 |author1=Clark HF |author2=Gurney AL |author3=Abaya E |name-list-style=vanc |last4=Baker |first4=K |last5=Baldwin |first5=D |last6=Brush |first6=J |last7=Chen |first7=J |last8=Chow |first8=B |last9=Chui |first9=C |pmc=403697 }}
• {{cite journal |title=Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo |journal=J. Immunol. |volume=171 |issue= 7 |pages= 3407–14 |year= 2004 |pmid= 14500635 |doi= 10.4049/jimmunol.171.7.3407|author1=Shi G |author2=Wu Y |author3=Zhang J |author4=Wu J |doi-access=free }}
• {{cite journal |title=Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication |journal=J. Leukoc. Biol. |volume=75 |issue= 2 |pages= 293–306 |year= 2004 |pmid= 14634066 |doi= 10.1189/jlb.0303119 |display-authors=3 |author1=Wu SF |author2=Liu TM |author3=Lin YC |name-list-style=vanc |last4=Sytwu |first4=HK |last5=Juan |first5=HF |last6=Chen |first6=ST |last7=Shen |first7=KL |last8=Hsi |first8=SC |last9=Hsieh |first9=SL |s2cid=14226200 |doi-access=free }}
• {{cite journal |title=Modulation of macrophage differentiation and activation by decoy receptor 3 |journal=J. Leukoc. Biol. |volume=75 |issue= 3 |pages= 486–94 |year= 2004 |pmid= 14657214 |doi= 10.1189/jlb.0903448 |display-authors=3 |author1=Chang YC |author2=Hsu TL |author3=Lin HH |name-list-style=vanc |last4=Chio |first4=CC |last5=Chiu |first5=AW |last6=Chen |first6=NJ |last7=Lin |first7=CH |last8=Hsieh |first8=SL |s2cid=31939119 |doi-access=free }}
• {{cite journal |title=Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells |journal=Infect. Immun. |volume=72 |issue= 1 |pages= 89–93 |year= 2004 |pmid= 14688085 |doi=10.1128/IAI.72.1.89-93.2004 |display-authors=3 |author1=Kim S |author2=McAuliffe WJ |author3=Zaritskaya LS |name-list-style=vanc |last4=Moore |first4=PA |last5=Zhang |first5=L |last6=Nardelli |first6=B |pmc=343977 }}
• {{cite journal |title=Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3 |journal=Exp. Cell Res. |volume=292 |issue= 2 |pages= 241–51 |year= 2004 |pmid= 14697332 |doi=10.1016/j.yexcr.2003.09.019 |display-authors=3 |author1=Hsu MJ |author2=Lin WW |author3=Tsao WC |name-list-style=vanc |last4=Chang |first4=YC |last5=Hsu |first5=TL |last6=Chiu |first6=AW |last7=Chio |first7=CC |last8=Hsieh |first8=SL }}
• {{cite journal |title=Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis |journal=Am. J. Pathol. |volume=165 |issue= 1 |pages= 309–17 |year= 2004 |pmid= 15215185 |doi= 10.1016/S0002-9440(10)63298-1|author1=Gill RM |author2=Hunt JS |pmc=1618528 }}

{{refend}}

• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=alps GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome]

{{NLM content}}

{{Tumor necrosis factor receptor superfamily}}

{{Cytokine receptor modulators}}