Dennie–Marfan syndrome

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Dennie–Marfan syndrome is a syndrome in which there is association of spastic paraplegia of the lower limbs and mental retardation in children with congenital syphilis.{{cite book|last1=M.D|first1=Mark E. Williams|title=Geriatric Physical Diagnosis: A Guide to Observation and Assessment|date=2009|publisher=McFarland|isbn=9780786451609|page=56|language=en}} Both sexes are affected, and the onset of the disease can be acute or insidious, with slow progression from weakness to quadriplegia. Epilepsy, cataract, and nystagmus may also be found.{{cn|date=August 2021}}

The syndrome was described by Charles Clayton Dennie in 1929,Dennie CC. Partial paralysis of the lower extremities in children, accompanied by backward mental development. Am J Syphilis 1929; 13: 157–163 and Antoine Marfan in 1936.Marfan AB. Paraplégie spasmodique avec troubles cérébraux d’origine hérédo-syphilitique chez les grands enfants. Revue Franc Pédiat 1936; 12: 1–16