Dermoepidermal junction

{{Short description|Interface between the epidermal and dermal layers of the skin}}

File:Epidermis, papillary dermis and reticular dermis.pnged section of human skin]]

The dermoepidermal junction or dermal-epidermal junction (DEJ) is the interface between the epidermal and the dermal layers of the skin. The basal cells of the epidermis connect to the basement membrane by the anchoring filaments of hemidesmosomes; the cells of the papillary layer of the dermis are attached to the basement membrane by anchoring fibrils, which consist of type VII collagen.{{cite web|url=http://www.netzwerk-eb.de/e14/e193/e249/index_eng.html|title=Dermo-epidermal junction zone|year=2006|publisher=Netzwerk Epidermolysis bullosa|access-date=30 November 2011|archive-url=https://archive.today/20130211120110/http://www.netzwerk-eb.de/e14/e193/e249/index_eng.html|archive-date=11 February 2013}}{{cite book|title=Gray's Anatomy: The Anatomical Basis of Clinical Practice|edition=41|year=2016|page=147|chapter=Skin and its appendages| veditors = Standring S |publisher=Elsevier|isbn=978-0-7020-5230-9}}

Clinical significance

Interface dermatitis includes conditions which primarily involve the dermoepidermal junction.{{cite journal | vauthors = Joshi R | title = Interface dermatitis | journal = Indian Journal of Dermatology, Venereology and Leprology | volume = 79 | issue = 3 | pages = 349–359 | date = May 2013 | pmid = 23619439 | doi = 10.4103/0378-6323.110780 | url = https://ijdvl.com/interface-dermatitis/ | archive-url = https://archive.today/20230309134338/https://ijdvl.com/interface-dermatitis/ | archive-date = 9 March 2023 | doi-access = free }}
Stevens–Johnson syndrome and toxic epidermal necrolysis are diseases where there is a breakdown of the dermoepidermal junction.

References

Category:Skin anatomy