Dextranomer

{{short description|Chemical compound}}

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| verifiedrevid = 460780406

| IUPAC_name = Dextran, 2,3-dihydroxypropyl 2-hydroxy-1,3-propanediyl ethers

| image = Dextranomer skeletal.svg

| tradename = Debrisan

| Drugs.com = {{drugs.com|international|dextranomer}}

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| routes_of_administration = Topical

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| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 56087-11-7

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 30KXI0TVD3

| ATC_prefix = D03

| ATC_suffix = AX02

| PubChemSubstance = 214362

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Dextranomer (trade name Debrisan, Exudex{{cite web|url=http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfRL/rl.cfm?lid=511319&lpcd=KOZ|archive-url=https://web.archive.org/web/20170207114637/http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfRL/rl.cfm?lid=511319&lpcd=KOZ|url-status=dead|archive-date=February 7, 2017|title=Establishment Registration & Device Listing|publisher=}}) is a cicatrizant used in dressings for wound healing,{{cite journal | vauthors = Parulkar BG, Sobti MK, Pardanani DS | title = Dextranomer dressing in the treatment of infected wounds and cutaneous ulcers | journal = J Postgrad Med | year = 1985 | volume = 31 | issue = 1 | pages = 28–33| pmid = 2413198 | url = http://www.jpgmonline.com/text.asp?1985/31/1/28/5431}} and in pharmaceutical products to treat fecal incontinence.{{cite web|url=https://www.drugs.com/news/solesta-gel-approved-fecal-incontinence-31669.html|title=Solesta Gel Approved for Fecal Incontinence - Drugs.com MedNews|publisher=}} It consists of dextran polymer chains cross-linked into a three-dimensional network.[http://solestainfo.com/docs/solesta_label.pdf Solesta Package Insert]

Solesta

Solesta is the marketed brand name of a system of injections of dextranomer in stabilized sodium hyaluronate for use in fecal incontinence (FI).{{cite journal|last=Hoy|first=SM|title=Dextranomer in stabilized sodium hyaluronate (Solesta): in adults with faecal incontinence.|journal=Drugs|date=Aug 20, 2012|volume=72|issue=12|pages=1671–8|pmid=22845415|doi=10.2165/11209030-000000000-00000|s2cid=6499631}} This preparation is a biocompatible gel, for use as a perianal injectable bulking agent. The system is intended to be injected in the submucosal layer of the proximal anal canal (i.e. above the level of the dentate line).

References

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