Dicyclohexyl phosphorofluoridate

{{Chembox

| Name = Dicyclohexyl phosphorofluoridate

| OtherNames = DCFP
Dicyclohexyl fluorophosphate
TL-941
T-1840

| ImageFile = Dicyclohexyl phosphorofluoridate.png

| Section1 = {{Chembox Identifiers

| CASNo = 587-15-5

| PubChem = 68518

| ChemSpiderID = 61793

| StdInChI=1S/C12H22FO3P/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h11-12H,1-10H2

| StdInChIKey = NLPYJEIDHPZCCR-UHFFFAOYSA-N

| SMILES = C1CCC(CC1)OP(=O)(OC2CCCCC2)F

}}

| Section2 = {{Chembox Properties

| C=12|H=22|F=1|O=3|P=1

| BoilingPtC = 116

| Appearance = Colorless liquid

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| Section3 = {{Chembox Hazards

| MainHazards = Extremely toxic

| LC50 = 110 mg/m3 (inhalation, mice, 10 minutes)
110 mg/m3 (inhalation, rabbits, 10 minutes)
110 mg/m3 (inhalation, rats, 10 minutes)

}}

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Dicyclohexyl phosphorofluoridate (DCFP),{{cite journal |last1=BERRY |first1=WK |title=The turnover number of cholinesterase. |journal=Biochemical Journal|date=October 1951 |volume=49 |issue=5 |pages=615–20 |doi=10.1042/bj0490615 |pmid=14886354|pmc=1197565 }} also known as TL-941 or T-1840,{{cite book |title=Chemical Warfare Agents, and Related Chemical Problems. Parts I-II. |date=1958 |url=https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB158508.xhtml}} is an extremely toxic organophosphorus compound with powerful anticholinesterase action. It's a colorless liquid that is extremely resistant to hydrolysis. DCFP can be produced by reaction of cyclohexanol with phosphoryl dichloride fluoride.{{cite book |title=Some Aspects Of The Chemistry And Toxic Action Of Organic Compounds Containing Phosphorus And Fluorine |date=1957 |url=https://archive.org/details/B-001-026-884-ALL}}

See also

References

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{{Chemical agents}}

{{Acetylcholine metabolism and transport modulators}}

Category:Acetylcholinesterase inhibitors

Category:Phosphorofluoridates

Category:Cyclohexyl compounds