Didier Stainier

Didier Stainier studied biology in Wales (United World College of the Atlantic), Belgium (University of Liège) and the USA (Brandeis University) where he got a BA in 1984. He has a PhD in biochemistry and biophysics from Harvard University (1990). During his PhD work, he investigated axon guidance and target recognition in the developing mouse with Walter Gilbert. Subsequently, he initiated the studies on zebrafish cardiac development as a Helen Hay Whitney postdoctoral fellow with Mark Fishman at the Massachusetts General Hospital (Boston).

Together with the many students and postdocs in his laboratory, Stainier helped pioneer the use of the zebrafish model to study a wide range of questions pertaining to vertebrate organ development and function,{{cite web|title=Transparent eggs of the zebra fish let researchers see how DNA directs embryonic development|url=http://www.sfgate.com/science/article/Window-On-Life-Transparent-eggs-of-the-zebra-3240679.php#photo-2387603|website=sfgate.com|date=7 February 2000 |accessdate=4 February 2018}} and has published extensively.{{cite web |title=Search results for author Stainier D |url=https://pubmed.ncbi.nlm.nih.gov/?term=stainier+d |website=on PubMed}}{{cite web|title=Scopus - author information|url=https://www.scopus.com/authid/detail.uri?authorId=7005076881|website=scopus.com|accessdate=4 February 2018}}{{cite web|title=Google Scholars - author information|url=https://scholar.google.com/citations?user=2rEmOPwAAAAJ|website=scholar.google.com|accessdate=4 February 2018}} His forward genetic analyses of heart development revealed the unexpected role of several signaling pathways including sphingosine 1-phosphate signaling{{cite journal |doi=10.1038/35018092 |pmid=10910360 |title=A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development |journal=Nature |volume=406 |issue=6792 |pages=192–5 |year=2000 |last1=Kupperman |first1=Erik |last2=An |first2=Songzhu |last3=Osborne |first3=Nick |last4=Waldron |first4=Steven |last5=Stainier |first5=Didier Y. R |bibcode=2000Natur.406..192K |s2cid=4412483 }} and the discovery of the long-elusive sphingosine 1-phosphate transporter.{{cite journal |doi=10.1016/j.cub.2008.10.061 |pmid=19062281 |pmc=2741689 |title=The Spinster Homolog, Two of Hearts, is Required for Sphingosine 1-Phosphate Signaling in Zebrafish |journal=Current Biology |volume=18 |issue=23 |pages=1882–8 |year=2008 |last1=Osborne |first1=Nick |last2=Brand-Arzamendi |first2=Koroboshka |last3=Ober |first3=Elke A |last4=Jin |first4=Suk-Won |last5=Verkade |first5=Heather |last6=Holtzman |first6=Nathalia Glickman |last7=Yelon |first7=Deborah |last8=Stainier |first8=Didier Y.R |bibcode=2008CBio...18.1882O }}{{cite web|title=A Small Fish Unlocks a Secret of the Heart|url=http://www.sfgate.com/news/article/A-Small-Fish-Unlocks-a-Secret-of-the-Heart-2713388.php|website=sfgate.com|date=17 July 2000 |accessdate=4 February 2018}} Additional genetic screens led to the elucidation of transcriptional networks regulating endoderm formation{{cite journal |doi=10.1016/S0960-9822(00)80016-0 |pmid=10531029 |title=A molecular pathway leading to endoderm formation in zebrafish |journal=Current Biology |volume=9 |issue=20 |pages=1147–57 |year=1999 |last1=Alexander |first1=Jonathan |last2=Stainier |first2=Didier Y.R |doi-access=free |bibcode=1999CBio....9.1147A }} and endothelial cell specification{{cite journal |doi=10.1038/nature18614 |pmid=27411634 |title=Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification |journal=Nature |volume=535 |issue=7611 |pages=294–8 |year=2016 |last1=Reischauer |first1=Sven |last2=Stone |first2=Oliver A |last3=Villasenor |first3=Alethia |last4=Chi |first4=Neil |last5=Jin |first5=Suk-Won |last6=Martin |first6=Marcel |last7=Lee |first7=Miler T |last8=Fukuda |first8=Nana |last9=Marass |first9=Michele |last10=Witty |first10=Alec |last11=Fiddes |first11=Ian |last12=Kuo |first12=Taiyi |last13=Chung |first13=Won-Suk |last14=Salek |first14=Sherveen |last15=Lerrigo |first15=Robert |last16=Alsiö |first16=Jessica |last17=Luo |first17=Shujun |last18=Tworus |first18=Dominika |last19=Augustine |first19=Sruthy M |last20=Mucenieks |first20=Sophie |last21=Nystedt |first21=Björn |last22=Giraldez |first22=Antonio J |last23=Schroth |first23=Gary P |last24=Andersson |first24=Olov |last25=Stainier |first25=Didier Y. R |bibcode=2016Natur.535..294R |s2cid=205264370 }} as well as extracellular signals regulating liver induction.{{cite journal |doi=10.1038/nature04888 |pmid=16799568 |title=Mesodermal Wnt2b signalling positively regulates liver specification |journal=Nature |volume=442 |issue=7103 |pages=688–91 |year=2006 |last1=Ober |first1=Elke A |last2=Verkade |first2=Heather |last3=Field |first3=Holly A |last4=Stainier |first4=Didier Y. R |bibcode=2006Natur.442..688O |s2cid=4318908 }} He pushed the frontiers of in vivo microscopy{{cite journal |doi=10.1126/science.1195929 |pmid=21071670 |title=Optogenetic Control of Cardiac Function |journal=Science |volume=330 |issue=6006 |pages=971–4 |year=2010 |last1=Arrenberg |first1=A. B |last2=Stainier |first2=D. Y. R |last3=Baier |first3=H |last4=Huisken |first4=J |bibcode=2010Sci...330..971A |s2cid=206529195 }} to reveal new insights into cardiac valve formation{{cite journal |doi=10.1126/science.293.5535.1670 |pmid=11533493 |title=UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish |journal=Science |volume=293 |issue=5535 |pages=1670–3 |year=2001 |last1=Walsh |first1=E. C |last2=Stainier |first2=D. Y |bibcode=2001Sci...293.1670W }} and cardiac trabeculation, and used cellular approaches to gain a detailed understanding of these processes. Stainier developed and used single-cell analyses to provide the first in vivo demonstration of the hemangioblast,{{cite journal |doi=10.1038/nature05045 |pmid=16988712 |title=A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula |journal=Nature |volume=443 |issue=7109 |pages=337–9 |year=2006 |last1=Vogeli |first1=Kevin M |last2=Jin |first2=Suk-Won |last3=Martin |first3=Gail R |last4=Stainier |first4=Didier Y. R |bibcode=2006Natur.443..337V |s2cid=4300264 }} a formerly hypothetical cell that gives rise to both endothelial and blood cells, as well as the discovery of a new mode of blood vessel formation.{{cite journal |doi=10.1126/science.1178577 |pmid=19815777 |pmc=2865998 |title=Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation |journal=Science |volume=326 |issue=5950 |pages=294–8 |year=2009 |last1=Herbert |first1=S. P |last2=Huisken |first2=J |last3=Kim |first3=T. N |last4=Feldman |first4=M. E |last5=Houseman |first5=B. T |last6=Wang |first6=R. A |last7=Shokat |first7=K. M |last8=Stainier |first8=D. Y. R |bibcode=2009Sci...326..294H }} His studies on gut looping morphogenesis revealed the importance of tissue-level physical forces in shaping organs,{{cite journal |doi=10.1126/science.1085397 |pmid=14576439 |title=A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish |journal=Science |volume=302 |issue=5645 |pages=662–5 |year=2003 |last1=Horne-Badovinac |first1=S |last2=Rebagliati |first2=M |last3=Stainier |first3=D. Y |bibcode=2003Sci...302..662H |s2cid=21421702 }} and his studies on gut lumen formation revealed the importance of fluid flow in this process.{{cite journal |doi=10.1038/ncb1621 |pmid=17632505 |title=Genetic control of single lumen formation in the zebrafish gut |journal=Nature Cell Biology |volume=9 |issue=8 |pages=954–60 |year=2007 |last1=Bagnat |first1=Michel |last2=Cheung |first2=Isla D|author3-link=Keith E. Mostov |last3=Mostov |first3=Keith E |last4=Stainier |first4=Didier Y. R |s2cid=2589754 }} He developed a number of cell ablation models that allowed him and others to gain new insights into the process of organ regeneration, with potential implications for novel disease therapies.{{cite journal |doi=10.1016/j.cmet.2012.04.018 |pmid=22608007 |pmc=3372708 |title=Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo |journal=Cell Metabolism |volume=15 |issue=6 |pages=885–94 |year=2012 |last1=Andersson |first1=Olov |last2=Adams |first2=Bruce A |last3=Yoo |first3=Daniel |last4=Ellis |first4=Gregory C |last5=Gut |first5=Philipp |last6=Anderson |first6=Ryan M |last7=German |first7=Michael S |last8=Stainier |first8=Didier Y.R }} Most recently, he has also made significant contributions to the understanding of genetic compensation.{{cite journal |doi=10.1038/nature14580 |pmid=26168398 |title=Genetic compensation induced by deleterious mutations but not gene knockdowns |journal=Nature |volume=524 |issue=7564 |pages=230–3 |year=2015 |last1=Rossi |first1=Andrea |last2=Kontarakis |first2=Zacharias |last3=Gerri |first3=Claudia |last4=Nolte |first4=Hendrik |last5=Hölper |first5=Soraya |last6=Krüger |first6=Marcus |last7=Stainier |first7=Didier Y. R |bibcode=2015Natur.524..230R |s2cid=4462277 }}{{cite journal |last1=El-Brolosy |first1=Mohamed A|last2=Kontarakis |first2=Zacharias | last3=Rossi |first3=Andrea | last4=Kuenne |first4=Carsten | last5=Günther |first5=Stefan | last6=Fukuda |first6=Nana | last7=Kikhi |first7=Khrievono | last8=Boezio |first8=Giulia L M | last9=Takacs |first9=Carter M | last10=Lai |first10=Shih-Lei | last11=Fukuda |first11=Ryuichi | last12=Gerri |first12=Claudia | last13=Giraldez |first13=Antonio J | last14=Stainier |first14=Didier Y R |title=Genetic compensation triggered by mutant mRNA degradation |journal=Nature |date=2019 |volume=568 |issue=7751 |pages=193–197 |doi=10.1038/s41586-019-1064-z |pmid=30944477|pmc=6707827 |bibcode=2019Natur.568..193E }}

• Wien International Scholar, Brandeis University 1982-1984
• Helen Hay Whitney Foundation Postdoctoral Fellow 1991-1994{{cite web|title=Helen Hay Whitney Foundation Fellow profile|url=http://hhwf.org/directory/profile/?userid=Njc2|website=hhwf.org|accessdate=4 February 2018}}
• Packard Foundation Fellow in Science and Engineering 1995-2000{{cite web|title=Packard Foundation Fellow in Science and Engineering|url=https://www.packard.org/what-we-fund/science/packard-fellowships-for-science-and-engineering/fellowship-directory/?keyword=Stainier&display|website=packard.org|accessdate=4 February 2018}}
• Established Investigator, American Heart Association 2000-2003
• Mossman Award in Developmental Biology, American Association of Anatomists 2002
• Annual Byers Award in Basic Science, UCSF 2003-2004
• Outstanding Faculty Mentorship Award, UCSF 2003
• NIH DEV1, study section founding Chair 2003-2006
• Elected Fellow of the American Association for the Advancement of Science 2008{{cite web|title=Elected Fellow of the American Association for the Advancement of Science|url=https://www.aaas.org/elected-fellows|website=aaas.org|accessdate=4 February 2018}}
• Officier dans l'ordre de Léopold de Belgique 2013{{cite web|title=Officier dans l'ordre de Léopold de Belgique, Nomination by Royal Decree published on 18 December 2013 on etaamb.be from the Belgian Official Journal|url=http://www.etaamb.be/fr/nomination-par-arrete-royal_n2013015274.html|website=etaamb.be|accessdate=4 February 2018}}
• European Research Council (ERC) Advanced Grant 2015{{cite web|title=Ten Max Planck researchers receive funding boosts worth millions|url=https://www.mpg.de/10464582/erc-advanced-grants-2016|website=mpg.de|accessdate=4 February 2018}}
• Elected Member of European Molecular Biology Organization (EMBO) 2016{{cite web|title=58 life science researchers elected as new EMBO Members|url=http://www.embo.org/news/press-releases/2016/58-life-science-researchers-elected-as-new-embo-members|website=embo.org|accessdate=4 February 2018|archive-date=15 August 2016|archive-url=https://web.archive.org/web/20160815104046/http://www.embo.org/news/press-releases/2016/58-life-science-researchers-elected-as-new-embo-members|url-status=dead}}{{cite web|title=EMBO member profile|url=https://people.embo.org/profile/didier-stainier|website=people.embo.org|accessdate=4 February 2018}}
• Elected Member of Academia Europaea 2016{{cite web|title=Academia Europaea member profile|url=http://www.ae-info.org/ae/Member/Stainier_Didier|website=ae-info.org|accessdate=4 February 2018}}
• Christiane Nüsslein-Volhard Award (European Zebrafish Society) 2017{{cite web|title=Didier Stainier receives 'Christiane Nüsslein-Volhard Award'|url=https://www.eufishbiomed.kit.edu/55.php|website=eufishbiomed.kit.edu|accessdate=4 February 2018}}{{cite web|title=Didier Stainier receives 'Christiane Nüsslein-Volhard Award'|url=http://www.mpi-hlr.de/en/info-services/press-information/content-press-information/article/christiane-nuesslein-volhard-preis-fuer-didier-stainier.html|website=mpi-hlr.de|accessdate=4 February 2018}}
• President, International Zebrafish Society (IZFS) 2020{{cite web|title=IZFS Board of Directors|url=https://www.izfs.org/about-us/board-of-directors}}
• European Research Council (ERC) Advanced Grant 2020{{cite web|title=Anerkennung hoch drei für Max-Planck|url=https://www.mpg.de/16889911/erc-advanced-grants-2020}}{{cite web|title=ERC-2020-ADG-results|url=https://erc.europa.eu/sites/default/files/document/file/erc-2020-adg-results-all-domains.pdf}}

{{Reflist|35em}}

• {{cite journal |doi=10.1083/jcb.2021pi |pmid=23836925 |pmc=3704995 |title=Didier Stainier: How function follows form |journal=The Journal of Cell Biology |volume=202 |issue=1 |pages=4–5 |year=2013 |last1=Sedwick |first1=Caitlin }}
• {{cite journal |doi=10.1242/dev.128769 |pmid=26329596 |title=An interview with Didier Stainier |journal=Development |volume=142 |issue=17 |pages=2861–3 |year=2015 |last1=Grewal |first1=S |doi-access=free }}

• [https://www.ibiology.org/development-and-stem-cells/vertebrate-organ-development-zebrafish-heart/#part-1 iBiology Seminar Part I: Vertebrate Organ Development: The Zebrafish Heart]
• [https://www.ibiology.org/development-and-stem-cells/vertebrate-organ-development-zebrafish-heart/#part-2 iBiology Seminar Part II: Cardiac Trabeculation]
• [https://www.ibiology.org/development-and-stem-cells/vertebrate-organ-development-zebrafish-heart/#part-3 iBiology Seminar Part III: Genetic Compensation]
• [https://www.youtube.com/watch?v=04ToBa4H0OA Positional cloning of cloche, a gene that drives endothelial and hematopoietic lineage specification. (Genetics Society of America)]
• [https://www.youtube.com/watch?v=YPi2qCaVCQo Curing Diabetes One Fish at a Time: The Long Road of Translational Research. (NIH Wednesday Afternoon Lecture Series)]

{{Scholia}}

• [https://www.mpi-hlr.de/46552/developmental-genetics Website Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research]
• [https://www.mpg.de/en Website of the Max Planck Society]
• {{PubMedAuthorSearch|Stainier|D}}
• [https://www.aaas.org/ Website of the American Association for the Advancement of Science]
• [https://erc.europa.eu/ Website of the European Research Council (ERC)]
• [https://embo.org Website of European Molecular Biology Organization (EMBO)]
• [http://www.ae-info.org/ Website of Academia Europaea]
• [https://elifesciences.org/ eLife website]
• [https://www.ezsociety.org// Website of the European Zebrafish Society]
• [https://www.izfs.org// Website of the International Zebrafish Society]

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Category:1963 births

Category:Belgian geneticists

Category:Brandeis University alumni

Category:Harvard Graduate School of Arts and Sciences alumni

Category:Living people

Category:Scientists from Liège

Category:People educated at Atlantic College

Category:People educated at a United World College

Category:Max Planck Institute directors

Category:Members of Academia Europaea