Digital Mammographic Imaging Screening Trial

{{More citations needed|date=March 2024}}

The Digital Mammographic Imaging Screening Trial (DMIST) is a multi-institutional research study, beginning in 2001, on the efficacy for screening of full-field digital mammography (FFDM) compared to conventional film-screen mammography that was sponsored by the U.S. National Cancer Institute and performed by the American College of Radiology Imaging Network (ACRIN).{{Cite web |last=Galen |first=Barbara |last2=Staab |first2=Edward |last3=Sullivan |first3=Daniel C. |last4=Pisano |first4=Etta D. |title=American College of Radiology Imaging Network: The Digital Mammographic Imaging Screening Trial—An Update |url=https://imaging.cancer.gov/programs_resources/reports_publications/publications/docs/ReportfromtheBiomedicalImagingProgram.pdf |access-date=13 December 2023 |website=National Cancer Institute}}

The findings{{cite journal |last=Pisano |first=Etta |date=27 October 2005 |title=Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening |url=http://content.nejm.org/cgi/content/full/353/17/1773 |journal=New England Journal of Medicine |publisher=NEJM |volume=353 |issue=17 |pages=1773–1783 |doi=10.1056/NEJMoa052911 |pmid=16169887 |access-date=11 February 2010 |doi-access=free}}{{cite journal | title = Film or Digital Mammographic Screening? | author-first = D. David| author-last = Dershaw | year = 2005 | journal = New England Journal of Medicine | pages = 1846-1847 | doi = 10.1056/NEJMe058253 | volume = 353 | issue = 17}} that FFDM was not inferior to the existing technology, and potentially superior in younger women with dense breasts, has led to a rapid proliferation of digital systems in the US.{{Cn|date=December 2023}} On the other hand, women with dense breasts receive two to three times the amount of radiation during their imaging as dense breasts absorb more X-ray because of the density (difficulty of the X-ray to penetrate dense tissue).{{Cn|date=December 2023}}