Dimethylcarbamoyl fluoride
{{Chembox
| Name = Dimethylcarbamoyl fluoride
| ImageFile = Dimethylcarbamoyl fluoride.svg
| ImageSize = 120px
| PIN = Dimethylcarbamoyl fluoride
| Section1 = {{Chembox Identifiers
| CASNo = 431-14-1
| ChemSpiderID = 9507
| PubChem = 9891
| SMILES = CN(C)C(=O)F
| StdInChI=1S/C3H6FNO/c1-5(2)3(4)6/h1-2H3
| StdInChIKey = IRSDGYFTDVBVAK-UHFFFAOYSA-N
}}
| Section2 = {{Chembox Properties
| C=3|H=6|F=1|N=1|O=1
| Appearance = Colorless liquid
| Solubility = Soluble
}}
| Section3 = {{Chembox Hazards
| MainHazards = Highly toxic
}}
| Section4 = {{Chembox Related
| OtherCompounds = Dimethylcarbamoyl chloride
}}
}}
Dimethylcarbamoyl fluoride is a chemical compound that can be produced by fluorination of dimethylcarbamoyl chloride with potassium fluoride.{{cite journal |last1=Cuomo |first1=John |last2=Olofson |first2=R. A. |title=Efficient and convenient synthesis of fluoroformates and carbamoyl fluorides |journal=The Journal of Organic Chemistry |date=March 1979 |volume=44 |issue=6 |pages=1016–1017 |doi=10.1021/jo01320a034}} It is a colorless liquid that is soluble and stable in water.{{cite journal |last1=Augustinsson |first1=K.B. |last2=Casida |first2=J.E. |title=Enzymic hydrolysis of N:N-dimethylcarbamoyl fluoride |journal=Biochemical Pharmacology |date=December 1959 |volume=3 |issue=1 |pages=60–67 |doi=10.1016/0006-2952(59)90009-7|pmid=13795122 }}{{cite journal |last1=MYERS |first1=DK |title=Studies on cholinesterase. 10. Return of cholinesterase activity in the rat after inhibition by carbamoyl fluorides |journal=The Biochemical Journal |date=April 1956 |volume=62 |issue=4 |pages=556–63 |pmid=13315214 |pmc=1215962 |doi=10.1042/bj0620556}}
Dimethylcarbamoyl fluoride is a potent cholinesterase inhibitor and is lethal even at low doses.
See also
References
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{{Acetylcholine metabolism and transport modulators}}
Category:Acetylcholinesterase inhibitors
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