Dimetotiazine

{{Short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 443778442

| IUPAC_name = 10-(2-Dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide

| image = Dimetotiazine.svg

| tradename =

| Drugs.com = {{drugs.com|international|dimetotiazine}}

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US =

| legal_status = Rx-only

| routes_of_administration = By mouth

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 7456-24-8

| ATC_prefix = N02

| ATC_suffix = CX05

| ATC_supplemental =

| PubChem = 3089

| DrugBank_Ref = {{drugbankcite|changed|drugbank}}

| DrugBank = DB08967

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 1FTA475ZDB

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D07854

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 2979

| synonyms = Dimethothiazine

| C=19 | H=25 | N=3 | O=2 | S=2

| SMILES = CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = VWNWVCJGUMZDIU-UHFFFAOYSA-N

}}

Dimetotiazine (INN) is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.{{cite journal | vauthors = Shimazawa M, Hara H, Watano T, Sukamoto T | title = Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats | journal = British Journal of Pharmacology | volume = 115 | issue = 8 | pages = 1359–68 | date = August 1995 | pmid = 8564192 | pmc = 1908864 | doi = 10.1111/j.1476-5381.1995.tb16624.x }}