Dimitri Kullmann

Kullmann was educated at the Lycée Français Charles de Gaulle and studied physiology at Balliol College, Oxford where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree.{{cite thesis|degree=DPhil|url=http://solo.bodleian.ox.ac.uk/OXVU1:LSCOP_OX:oxfaleph013219144|title=Central actions of muscle receptors|first=Dimitri Michael|last=Kullman|year=1984|id={{EThOS|uk.bl.ethos.353099}}|publisher=University of Oxford|oclc=59330270|hdl=|access-date=6 June 2018|archive-date=16 December 2019|archive-url=https://web.archive.org/web/20191216233156/http://solo.bodleian.ox.ac.uk/OXVU1:LSCOP_OX:oxfaleph013219144|url-status=dead}} He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London. His postgraduate research was supervised by Julian Jack.

Kullmann's research investigates how synapses function in health and disease. His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength. Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine. Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy.

The Kullmann lab has contributed to the discovery and elucidation of silent synapses,{{Cite journal|last=Kullmann|first=Dimitri M.|title=Amplitude fluctuations of|journal=Neuron|volume=12|issue=5|pages=1111–1120|doi=10.1016/0896-6273(94)90318-2|pmid=7910467|year=1994|s2cid=54357872}} glutamate spillover, tonic inhibition,{{cite journal|last1=Semyanov|first1=Alexey|last2=Walker|first2=Matthew C.|last3=Kullmann|first3=Dimitri M.|last4=Silver|first4=R.Angus|title=Tonically active GABAA receptors: modulating gain and maintaining the tone|journal=Trends in Neurosciences|volume=27|issue=5|year=2004|pages=262–269|issn=0166-2236|doi=10.1016/j.tins.2004.03.005|pmid= 15111008|s2cid=2660172}} long-term potentiation in interneurons,{{Cite journal|last1=Lamsa|first1=Karri P.|last2=Heeroma|first2=Joost H.|last3=Somogyi|first3=Peter|last4=Rusakov|first4=Dmitri A.|last5=Kullmann|first5=Dimitri M.|year=2007|title=Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit|journal=Science|volume=315|issue=5816|pages=1262–1266|doi=10.1126/science.1137450|issn=1095-9203|pmc=3369266|pmid=17332410|bibcode=2007Sci...315.1262L}} neurological channelopathies{{Cite journal|last=Kullmann|first=Dimitri M.|year=2010|title=Neurological channelopathies|journal=Annual Review of Neuroscience|volume=33|pages=151–172|doi=10.1146/annurev-neuro-060909-153122|issn=1545-4126|pmid=20331364}} and Synaptopathies, gene therapy for epilepsy,{{Cite journal|last1=Wykes|first1=Robert C.|last2=Heeroma|first2=Joost H.|last3=Mantoan|first3=Laura|last4=Zheng|first4=Kaiyu|last5=MacDonald|first5=Douglas C.|last6=Deisseroth|first6=Karl|last7=Hashemi|first7=Kevan S.|last8=Walker|first8=Matthew C.|last9=Schorge|first9=Stephanie|year=2012|title=Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy|journal=Science Translational Medicine|volume=4|issue=161|pages=161ra152|doi=10.1126/scitranslmed.3004190|issn=1946-6242|pmc=3605784|pmid=23147003}} and mechanisms of neural oscillations.{{Cite journal|last1=Akam|first1=Thomas|last2=Oren|first2=Iris|last3=Mantoan|first3=Laura|last4=Ferenczi|first4=Emily|last5=Kullmann|first5=Dimitri M.|year=2012|title=Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling|journal=Nature Neuroscience|volume=15|issue=5|pages=763–768|doi=10.1038/nn.3081|issn=1546-1726|pmc=3378654|pmid=22466505}} Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020{{cite web|url=http://brain.oxfordjournals.org/editorial_board.html |archive-url=https://web.archive.org/web/20141011031700/http://brain.oxfordjournals.org/editorial_board.html |url-status=dead |archive-date=11 October 2014 |title=Editorial board | Brain |website=Brain.oxfordjournals.org |date=26 September 2016 |access-date=2 October 2016}} and is on the editorial board of the journal Neuron.{{cite web|url=http://www.cell.com/neuron/editorial-board|title=Editorial Board: Neuron|website=cell.com}} Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco.

Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986. and the Baly Medal by the Royal College of Physicians in 2017. He was elected a Guarantor of Brain in 2000,{{cite web|url=http://www.guarantorsofbrain.org/ |title=Guarantors of Brain |publisher=Guarantors of Brain |access-date=11 August 2016}} elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001,{{cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Dimitri-Kullmann-0006016/ |title=Professor Dimitri Kullmann FMedSci |website=acmedsci.ac.uk |access-date=2 October 2016}} a Corresponding Fellow of the American Neurological Association in 2013,{{cite web|url=https://myana.org/member-directory/search?search_api_views_fulltext=kullmann |title=American Neurological Association (ANA) |publisher=Myana.org |access-date=1 November 2016}} a member of the Academia Europaea (MAE) in 2017{{cite web|url=http://www.ae-info.org/ae/Member/Kullmann_Dimitri|title=Academy of Europe: Kullmann Dimitri|first=Ilire Hasani, Robert|last=Hoffmann|website=ae-info.org}} and a Fellow of the Royal Society (FRS) in 2018.{{cite web|url=https://royalsociety.org/people/dimitri-kullmann-13824/ |title=Professor Dimitri Kullmann FMedSci FRS |website=royalsociety.org|publisher=Royal Society|location=London|author=Anon|year=2018|archive-url=https://web.archive.org/web/20180524003540/https://royalsociety.org/people/dimitri-kullmann-13824/|archive-date=24 May 2018}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{blockquote|"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}} He was awarded the 2023 Basic Science Research Award by the American Epilepsy Society.{{cite web|url=https://aesnet.org/about/aes-press-room/press-releases/dimitri-m.-kullmann-d.phil.-frs-fmedsci-mae-receives-2023-basic-science-research-award |title=Dimitri M. Kullmann, D.Phil., FRS, FMedSci, MAE, Receives the 2023 Basic Science Research Award }}

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Category:1958 births

Category:Living people

Category:People educated at Lycée Français Charles de Gaulle

Category:Fellows of the Royal Society

Category:Fellows of the Academy of Medical Sciences (United Kingdom)

Category:Members of Academia Europaea

Category:Alumni of the University of Oxford

Category:Alumni of Balliol College, Oxford