Disodium phosphate

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| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 457118728

| ImageFile = Disodium hydrogen phosphate.png

| ImageSize = 150px

| ImageAlt = Structural formula of disodium phosphate

| ImageFile1 = Disodium phosphate 3D spacefill.png

| ImageSize1 = 250

| ImageAlt1 = Ball-and-stick model of the component ions of disodium phosphate

| ImageCaption1 = {{legend|purple|Sodium, Na}}{{legend|orange|Phosphorus, P}}{{legend|red|Oxygen, O}}{{legend|white|Hydrogen, H}}

| ImageFile2 = Hydrogenfosforečnan sodný dodekahydrát.jpg

| IUPACName = Disodium hydrogen phosphate

| OtherNames = {{ubl|Acetest|Dibasic sodium phosphate|Disodium hydrogen orthophosphate|Disodium hydrogen phosphate|Disodium phosphate|Sodium phosphate dibasic}}

| SystematicName =

| Section1 = {{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 22625

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 22ADO53M6F

| UNII2_Ref = {{fdacite|correct|FDA}}

| UNII2 = 94255I6E2T

| UNII2_Comment = (dihydrate)

| UNII3_Ref = {{fdacite|correct|FDA}}

| UNII3 = 70WT22SF4B

| UNII3_Comment = (heptahydrate)

| UNII4_Ref = {{fdacite|correct|FDA}}

| UNII4 = E1W4N241FO

| UNII4_Comment = (dodecahydrate)

| InChI = 1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 1060

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 34683

| SMILES = OP(=O)([O-])[O-].[Na+].[Na+]

| InChIKey = BNIILDVGGAEEIG-DFZHHIFOAK

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = BNIILDVGGAEEIG-UHFFFAOYSA-K

| StdInChI = 1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| CASNo = 7558-79-4

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo2_Ref = {{cascite|correct|CAS}}

| CASNo2 = 10028-24-7

| CASNo2_Comment = (dihydrate)

| CASNo3_Ref = {{cascite|correct|CAS}}

| CASNo3 = 7782-85-6

| CASNo3_Comment = (heptahydrate)

| CASNo4_Ref = {{cascite|correct|CAS}}

| CASNo4 = 10039-32-4

| CASNo4_Comment = (dodecahydrate)

| PubChem = 24203

| EINECS = 231-448-7

| RTECS = WC4500000

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| Section2 = {{Chembox Properties

| Formula = {{chem2|Na2HPO4}}

| MolarMass = {{ubl|141.96 g/mol (anhydrous)|177.99 g/mol (dihydrate)|268.07 g/mol (heptahydrate)}}

| Appearance = White crystalline solid

| RefractIndex = 1.35644 to 1.35717 at 20°C

| Odor = Odorless

| Density = 1.7 g/cm3

| MeltingPtC = 250

| MeltingPt_notes = Decomposes

| Solubility = 7.7 g/(100 ml) (20 °C)
11.8 g/(100 ml) (25 °C, heptahydrate)

| SolubleOther = Insoluble in ethanol

| pKa = 12.35

| LogP = −5.8

| MagSus = −56.6·10−6 cm3/mol

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| Section3 =

| Section4 =

| Section5 =

| Section6 =

| Section7 = {{Chembox Hazards

| ExternalSDS = [http://www.inchem.org/documents/icsc/icsc/eics1129.htm ICSC 1129]

| NFPA-H = 1

| NFPA-F = 0

| NFPA-R = 0

| MainHazards = Irritant

| FlashPt = Non-flammable

| LD50 = 17000 mg/kg (rat, oral)

}}

| Section8 = {{Chembox Related

| OtherAnions = sodium phosphite

| OtherCations = Dipotassium phosphate
Diammonium phosphate

| OtherCompounds = Monosodium phosphate
Trisodium phosphate

}}

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Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is an inorganic compound with the chemical formula {{chem2|Na2HPO4|auto=1}}. It is one of several sodium phosphates. The salt is known in anhydrous form as well as hydrates {{chem2|Na2HPO4*nH2O}}, where n is 2, 7, 8, and 12. All are water-soluble white powders. The anhydrous salt is hygroscopic.{{Cite web |url=http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf |title=Physical data (pdf) |access-date=2007-03-06 |archive-url=https://web.archive.org/web/20110717102830/http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf |archive-date=2011-07-17 |url-status=dead}}

The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic:

:{{chem2|HPO4(2−) + H2O ⇌ H2PO4− + OH−}}

Production and reactions

It can be generated by neutralization of phosphoric acid with sodium hydroxide:

:{{chem2|H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O}}

Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:Klaus Schrödter, Gerhard Bettermann, Thomas Staffel, Friedrich Wahl, Thomas Klein, Thomas Hofmann "Phosphoric Acid and Phosphates" in Ullmann’s Encyclopedia of Industrial Chemistry 2008, Wiley-VCH, Weinheim. {{doi|10.1002/14356007.a19_465.pub3}}

:{{chem2|CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4}}

In the second step, the resulting solution of monosodium phosphate is partially neutralized:

:{{chem2|NaH2PO4 + NaOH → Na2HPO4 + H2O}}

Uses

It is used in conjunction with trisodium phosphate in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, it is used as an anti-caking additive in powdered products.{{Cite web |url=http://www.sciencelab.com/msds.php?msdsId=9925023 |title=MSDS |access-date=2011-09-26 |archive-url=https://web.archive.org/web/20171028050920/http://www.sciencelab.com/msds.php?msdsId=9925023 |archive-date=2017-10-28 |url-status=dead}} It is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening. In water treatment, it retards calcium scale formation.{{Citation needed|date=September 2021}} It is also found in some detergents and cleaning agents.

Heating solid disodium phosphate gives the useful compound tetrasodium pyrophosphate:{{citation needed|date=July 2016}}

:{{chem2|2 Na2HPO4 → Na4P2O7 + H2O}}

= Laxative =

Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.{{Cite web | url = http://wishardhealth.kramesonline.com/Medications/26,1558 | title = Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic Oral solution | publisher = Krames Patient Education | access-date = 2009-10-29 | archive-url = https://archive.today/20130128005243/http://wishardhealth.kramesonline.com/Medications/26,1558 | archive-date = 2013-01-28 | url-status = dead}}

References

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