Dolosigranulum pigrum

{{Short description|Species of bacterium}}

{{italic title}}

{{Taxobox

| name = Dolosigranulum pigrum

| domain = Bacteria

| phylum = Bacillota

| classis = Bacilli

| ordo = Lactobacillales

| familia = Carnobacteriaceae

| genus = Dolosigranulum

| species = D. pigrum

| binomial = Dolosigranulum pigrum

| binomial_authority = Aguirre et al. 1994{{cite journal|last1=Parte|first1=A.C.|title=Dolosigranulum|journal=LPSN|url=https://lpsn.dsmz.de/genus/dolosigranulum}}

| type_strain = ATCC 51524, CCUG 33392, CIP 104051, IFO 15550, LMG 15126, NBRC 15550, NCFB 2975, NCIMB 702975, R91/1468{{cite journal|title=Dolosigranulum pigrum|website=www.uniprot.org|url=https://www.uniprot.org/taxonomy/29394}}

| subdivision =

| synonyms =

}}

Dolosigranulum pigrum is a Gram-positive bacterium from the genus of Dolosigranulum.{{cite book|last1=Stephen|first1=Dr. Berger|title=GIDEON Guide to Medically Important Bacteria|date=2015|publisher=GIDEON Informatics Inc|isbn=978-1-4988-0429-5}} Dolosigranulum pigrum can cause infections in the upper respiratory tract and nosocomial pneumonia and sepsis.{{cite web |title=Dolosigranulum pigrum ATCC 51524 (ID 67783) - BioProject - NCBI|website =www.ncbi.nlm.nih.gov|url=https://www.ncbi.nlm.nih.gov/bioproject/67783}}{{cite journal|last1=Laclaire|first1=L.|last2=Facklam|first2=R.|title=Antimicrobial Susceptibility and Clinical Sources of Dolosigranulum pigrum Cultures|journal=Antimicrobial Agents and Chemotherapy|date=1 July 2000|volume=44|issue=7|pages=2001–2003|doi=10.1128/AAC.44.7.2001-2003.2000|pmc=90003|pmid=10858372}}{{cite journal|last1=Lecuyer|first1=H.|last2=Audibert|first2=J.|last3=Bobigny|first3=A.|last4=Eckert|first4=C.|last5=Janniere-Nartey|first5=C.|last6=Buu-Hoi|first6=A.|last7=Mainardi|first7=J.-L.|last8=Podglajen|first8=I.|title=Dolosigranulum pigrum Causing Nosocomial Pneumonia and Septicemia|journal=Journal of Clinical Microbiology|date=8 August 2007|volume=45|issue=10|pages=3474–3475|doi=10.1128/JCM.01373-07|pmc=2045320|pmid=17687015}}

The metabolism of this organism has been reconstructed. It is available as a genome-scale metabolic model, which indicates incomplete biochemical pathways within the central carbon metabolism.

{{cite journal

| first1 = Alina | last1 = Renz

| first2 = Lina | last2 = Widerspick

| first3 = Andreas | last3 = Dräger

| author-link3 = Andreas Dräger

| date = 2021

| title = First Genome-Scale Metabolic Model of Dolosigranulum pigrum Confirms Multiple Auxotrophies

| journal = Metabolites

| volume = 11

| issue = 4

| page = 232

| doi = 10.3390/metabo11040232

| pmc = 8069353

| pmid = 33918864

| s2cid =

| doi-access = free

}}

Consequently, its metabolism depends on other members of its microbial habitat, such as Staphylococcus aureus, whose growth D. pigrum negatively impacts..

{{cite journal

| first1 = Reihaneh | last1 = Mostolizadeh

| first2 = Manuel | last2 = Glöckler

| first3 = Andreas | last3 = Dräger

| author-link3 = Andreas Dräger

| date = 2022

| title = Towards the human nasal microbiome: simulating D. pigrum and S. aureus

| journal = Frontiers in Cellular and Infection Microbiology

| volume = 12

| issue =

| page =

| doi = 10.3389/fcimb.2022.925215

| pmc = 9810029

| pmid = 36605126

| s2cid =

| doi-access = free

}}

D. pigrum is highly adapted to the human nasal passages. In an analysis of 8,184 samples from 6 human body sites, Dolosigranulum sequencing reads were identified in 41% of nasal samples, 15% of skin samples, and <1% of fecal and oral cavity samples. Moreover, in samples in which Dolosigranulum was detected, the organism was far more abundant in nasal samples (18% mean relative abundance) than in samples from other body sites (<2% mean relative abundance). Analyses of data from the Earth Microbiome Project revealed that Dolosigranulum reads were rarely identified in environmental sources (e.g., water, soil) but were identified in samples from a variety of animal species, including rodents, fish, birds, dogs, and primates.{{cite journal |last1=Stubbendieck |first1=Reed M. |last2=Hurst |first2=Jillian H. |last3=Kelly |first3=Matthew S. |title=Dolosigranulum pigrum: A promising nasal probiotic candidate |journal=PLOS Pathogens |date=1 February 2024 |volume=20 |issue=2 |pages=e1011955 |doi=10.1371/journal.ppat.1011955 |url=https://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1011955 |language=en |issn=1553-7374 |doi-access=free |pmc=10833571 }}{{Creative Commons text attribution notice|cc=by4|from this source=yes}}