Domine Database

{{infobox biodatabase

|title = DOMINE

|logo =File:Database.png

|description =comprehensive collection of known and predicted domain-domain interactions.

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|center =National Institute of Environmental Health Sciences, National Institutes of Health

|laboratory = Systems Biology

|author =

|citation = Yellaboina et al. (2011){{cite journal | author = Yellaboina|date=Jan 2011|title=DOMINE: a comprehensive collection of known and predicted domain-domain interactions|journal = Nucleic Acids Res.|volume=39|issue=Database issue|pages=D730-5|location = England| pmid = 21113022|doi = 10.1093/nar/gkq1229| pmc =3013741 |display-authors=etal}}

|released = 2010

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|url = https://manticore.niehs.nih.gov/domine

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}}DOMINE is a database of known and predicted protein domain interactions (or domain-domain interactions). It contains interactions observed in PDB crystal structures, and those predicted by several computational approaches. DOMINE uses Pfam HMM profiles for protein domain definitions. The DOMINE database contains 26,219 interactions among 5,410 domains), which includes 6,634 known interactions inferred from PDB structure data.