Donovan's solution
{{Chembox
| Name = Donovan's Solution
| ImageFile =
| ImageSize =
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| IUPACName = Iodomercury; triiodoarsane
| OtherNames = Liquor hydriodatis arsenici et hydrargyri
|Section1={{Chembox Identifiers
| CASNo = 8012-54-2
| CASNo_Ref = {{Cascite|correct|CAS}}
| InChI = 1S/AsI3.Hg.HI/c2-1(3)4;;/h;;1H/q;+1;/p-1
| InChIKey = QLULWSBMTZWVDE-UHFFFAOYSA-M
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| PubChem = 24679
| ChemSpiderID = 23077
| ChemSpiderID_Ref =
| RTECS = CG3200000
| SMILES = [As](I)(I)I.I[Hg]
| UNNumber = 1557
}}
|Section2={{Chembox Properties
| Formula = AsHgI4
| MolarMass = 783.12948
| Appearance = Clear, colourless, or pale yellow. Darkens with age.
| Density =
| MeltingPt =
| BoilingPtC = 403
| BoilingPt_notes = at 760 mmHg
| Solubility = Yes
}}
|Section3={{Chembox Hazards
| MainHazards = Toxic
| FlashPt =
| AutoignitionPt =
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| Verifiedfields =
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Donovan's solution is an inorganic compound prepared from arsenic triiodide and mercuric iodide.{{cite book|last=Budavari|first=Susan|title=The Merck Index|year=1989|publisher=Merck & Co., Inc.|isbn=091191028X|page=[https://archive.org/details/merckindexency00buda/page/537 537]|chapter=3413. Donovan's Solution|lccn=89060001|edition=11th|chapter-url-access=registration|chapter-url=https://archive.org/details/merckindexency00buda/page/537}} Despite its name, it is a compound and not a solution.
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Method
Donovan's solution can be prepared by mixing arsenic triiodide, mercuric iodide, and sodium bicarbonate in aqueous solution.{{Cite book |last=Navy Department. Bureau of Medicine and Surgery |url=https://books.google.com/books?id=t5JzPfXyrVcC&pg=PA17 |title=Pharmacy and Materia Medica: Military-medical Operations Courses |publisher=Bureau of Naval Personnel |year=1950 |pages=17}}
Cooley's cyclopædia of practical receipts and ... information on the arts, manufactures, and trades gives a more complex method.{{cite book|title=A cyclopædia of practical receipts and ... information on the arts, manufactures, and trades|year=1880|page=1525|chapter-url=https://books.google.com/books?id=rUMCAAAAQAAJ&q=Donovan%27s+solution&pg=PA1525|author=Arnold James Cooley|edition=6th|author-link=Arnold James Cooley|editor=Richard Vine Tuson|chapter=Solution|volume=II}}
Uses
The solution has been used in veterinary medicine to treat chronic diseases of the skin{{cite book|last=Oxtoby|first=David W.|author2=H.P. Gillis|author3=Allan Campion|title=Principles of modern chemistry|publisher=Brooks/Cole Cengage Learning|location=Belmont, Calif.|isbn=978-0840049315|page=513|url=https://books.google.com/books?id=fJWpg4ZJ2esC&q=Donovan%27s+solution&pg=PA513|edition=7th|year=2012}} and as a folk remedy.{{cite web|title=Donovan's solution|url=http://www.chemicaldictionary.org/dic/D/Donovans-solution_1418.html|work=Chemical Dictionary Online|access-date=29 November 2013}} It was used during the 19th century to treat lepra vulgaris{{cite book|title=On Diseases of the Skin|year=1847|publisher=John Churchill|page=271|chapter-url=https://books.google.com/books?id=Hx0SAAAAYAAJ&q=Donovan%27s+solution&pg=PA271|author=Sir Erasmus Wilson|edition=2nd|author-link=William James Erasmus Wilson|chapter=Treatment of Lepra}} and psoriasis{{cite book|title=A Treatise On The Materia Medica And Therapeutics Of The Skin|url=http://chestofbooks.com/health/materia-medica-drugs/Treatise-On-Materia-Medica-Therapeutics-Skin/Psoriasis-Treatment-Part-6.html|author=Henry G. Piffard|author-link=Henry Granger Piffard|chapter=Psoriasis Treatment. Part 6|page=254|chapter-url=https://books.google.com/books?id=rhkDAAAAQAAJ&q=Donovan%27s|year=1881|publisher=Sampson, Low, Marston, Searle & Rivington}}{{cite journal|journal=The Lancet|date=August 1857|volume=70|issue=1770|page=116|doi=10.1016/S0140-6736(02)38789-0|url=https://books.google.com/books?id=NbI1AQAAMAAJ&q=%22Donovan%27s+solution%22&pg=PA116|title=Good Results of Donovan's Solution in Psoriasis|url-access=subscription}} in humans, taken internally.
References
{{Reflist}}
{{Arsenic compounds}}
{{iodine compounds}}
{{Mercury compounds}}
{{DEFAULTSORT:Donovan's solution}}