Douglas Higgs

He was educated at Alleyn's School and qualified in medicine at King's College Hospital Medical School in 1974, and trained as a haematologist. He became a registrar in Haematology at Kings College Hospital in 1976.

He joined the Molecular Haematology Unit of the Medical Research Council at Oxford in 1977. In 1996 he was appointed Ad Hominem Professor of Molecular Haematology. In 2001, he became a director of the MRC Molecular Haematology Unit (MHU).{{Cite web|url=https://www.mrc.ac.uk/news/browse/top-haematologist-announced-as-new-director-of-mrc-weatherall-institute-of-molecular-medicine/|title=Top haematologist announced as new Director of MRC Weatherall Institute of Molecular Medicine|last=MRC|first=Medical Research Council|date=18 May 2017|website=mrc.ac.uk|access-date=16 March 2018}} In 2012, Higgs was appointed director of the Weatherall Institute of Molecular Medicine (WIMM).{{Cite web|url=https://www.imm.ox.ac.uk/new-weatherall-institute-of-molecular-medicine-director-announced|title=New Weatherall Institute of Molecular Medicine director announced – Weatherall Institute of Molecular Medicine|publisher=University of Oxford|access-date=16 March 2018}} In 2020, Higgs was succeeded as director of the MRC MHU and WIMM by Ketan J. Patel.{{Cite web |title=MRC WIMM appoints new Director |url=https://www.imm.ox.ac.uk/news/mrc-wimm-appoints-new-director |access-date=2023-12-01 |website=imm.ox.ac.uk |language=en}} Higgs is a Senior Kurti Fellow at Brasenose College, Oxford.{{Cite news|url=https://www.bnc.ox.ac.uk/downloads/brazen_notes/the_brazen_nose_2010.pdf|title=The Brazen Nose|date=2009–2010}}

• 1993 Fellow of the Royal College of Physicians
• 1994 Fellow of the Royal College of Pathologists
• 2001 Fellow of the Academy of Medical Sciences{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglas-higgs|title=Professor Douglas Higgs {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=16 March 2018|archive-date=17 March 2018|archive-url=https://web.archive.org/web/20180317102408/https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglas-higgs|url-status=dead}}
• 2005 Fellow of the Royal Society{{Cite web|url=https://royalsociety.org/people/douglas-higgs-11613/|title=Douglas Higgs|website=royalsociety.org|access-date=16 March 2018}}
• 2013 Buchanan Medal of the Royal Society{{Cite web|url=https://www.imm.ox.ac.uk/buchanan-medal-awarded|title=Buchanan Medal Awarded – Weatherall Institute of Molecular Medicine|publisher=University of Oxford|access-date=16 March 2018|archive-url=https://web.archive.org/web/20180317102043/https://www.imm.ox.ac.uk/buchanan-medal-awarded|archive-date=17 March 2018|url-status=dead}}{{cite web|url=http://royalsociety.org/awards/buchanan-medal/|title = The Buchanan Medal (1897)|publisher=The Royal Society|access-date=12 September 2013}} for "his seminal work on the regulation of the human alpha-globin gene cluster and the role of the ATRX protein in genetic disease."
• 2023 The Genetics Society Medal.

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{{Cite journal|last1=Gibbons|first1=Richard J|last2=Picketts|first2=David J|last3=Villard|first3=Laurent|last4=Higgs|first4=Douglas R|title=Mutations in a putative global transcriptional regulator cause X-linked mental retardation with α-thalassemia (ATR-X syndrome)|journal=Cell|volume=80|issue=6|pages=837–845|doi=10.1016/0092-8674(95)90287-2|pmid=7697714|year=1995|s2cid=16411046|doi-access=free}}

{{Cite journal|last1=Tufarelli|first1=Cristina|last2=Stanley|first2=Jackie A Sloane|last3=Garrick|first3=David|last4=Sharpe|first4=Jackie A|last5=Ayyub|first5=Helena|last6=Wood|first6=William G|last7=Higgs|first7=Douglas R|year=2003|title=Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease|journal=Nature Genetics|volume=34|issue=2|pages=157–165|doi=10.1038/ng1157|issn=1546-1718|pmid=12730694|s2cid=7226446}}

{{Cite journal|last1=Higgs|first1=D. R.|last2=Goodbourn|first2=S. E. Y.|last3=Lamb|first3=J.|last4=Clegg|first4=J. B.|last5=Weatherall|first5=D. J.|last6=Proudfoot|first6=N. J.|year=1983|title=α-Thalassaemia caused by a polyadenylation signal mutation|journal=Nature|volume=306|issue=5941|pages=398–400|doi=10.1038/306398a0|pmid=6646217|bibcode=1983Natur.306..398H |s2cid=4332750|issn=1476-4687}}

{{Cite journal|last1=Wilkie|first1=Andrew O. M.|last2=Lamb|first2=Janette|last3=Harris|first3=Peter C.|last4=Finney|first4=Roger D.|last5=Higgs|first5=Douglas R.|year=1990|title=A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n|journal=Nature|volume=346|issue=6287|pages=868–871|doi=10.1038/346868a0|pmid=1975428|bibcode=1990Natur.346..868W |s2cid=4239520|issn=1476-4687}}

{{Cite journal|last1=Nicholls|first1=R.D.|last2=Fischel-Ghodsian|first2=N.|last3=Higgs|first3=D.R.|title=Recombination at the human α-globin gene cluster: Sequence features and topological constraints|journal=Cell|volume=49|issue=3|pages=369–378|doi=10.1016/0092-8674(87)90289-3|year=1987|pmid=3032452|s2cid=54349888}}

{{Cite journal|last1=De Gobbi|first1=Marco |last2=Viprakasit|first2=Vip|last3=Hughes|first3=Jim R.|last4=Fisher|first4=Chris|last5=Buckle|first5=Veronica J.|last6=Ayyub|first6=Helena|last7=Gibbons|first7=Richard J.|last8=Vernimmen|first8=Douglas|last9=Yoshinaga|first9=Yuko|date=26 May 2006|title=A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter|journal=Science|volume=312|issue=5777|pages=1215–1217|doi=10.1126/science.1126431|issn=0036-8075|pmid=16728641|bibcode=2006Sci...312.1215D |s2cid=16044469}}

{{Cite journal|last1=Law|first1=Martin J.|last2=Lower|first2=Karen M.|last3=Voon|first3=Hsiao P.J.|last4=Hughes|first4=Jim R.|last5=Garrick|first5=David|last6=Viprakasit|first6=Vip|last7=Mitson|first7=Matthew|last8=De Gobbi|first8=Marco |last9=Marra|first9=Marco|title=ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner|journal=Cell|volume=143|issue=3|pages=367–378|doi=10.1016/j.cell.2010.09.023|pmid=21029860|year=2010|doi-access=free}}

{{Cite journal|last1=Hughes|first1=Jim R|last2=Roberts|first2=Nigel|last3=McGowan|first3=Simon|last4=Hay|first4=Deborah|last5=Giannoulatou|first5=Eleni|last6=Lynch|first6=Magnus|last7=De Gobbi|first7=Marco |last8=Taylor|first8=Stephen|last9=Gibbons|first9=Richard|year=2014|title=Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment|journal=Nature Genetics|volume=46|issue=2|pages=205–212|doi=10.1038/ng.2871|pmid=24413732|hdl=2318/144575 |s2cid=205348099|issn=1546-1718|url=https://ora.ox.ac.uk/objects/uuid:70c4e8bd-b9fb-40a2-a40c-4052d65a48f7|hdl-access=free}}

{{Cite journal|last1=Higgs|first1=Douglas R.|last2=Gibbons|first2=Richard J.|last3=McDowell|first3=Tarra L.|last4=Raman|first4=Sundhya|last5=O'Rourke|first5=Delia M.|last6=Garrick|first6=David|last7=Ayyub|first7=Helena|year=2000|title=Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation|journal=Nature Genetics|volume=24|issue=4|pages=368–371|doi=10.1038/74191|pmid=10742099|s2cid=8847855|issn=1546-1718}}

{{Cite journal|last1=Hay|first1=Deborah|last2=Hughes|first2=Jim R|last3=Babbs|first3=Christian|last4=Davies|first4=James O J|last5=Graham|first5=Bryony J|last6=Hanssen|first6=Lars L P|last7=Kassouf|first7=Mira T|last8=Oudelaar|first8=A Marieke|last9=Sharpe|first9=Jacqueline A|year=2016|title=Genetic dissection of the α-globin super-enhancer in vivo|journal=Nature Genetics|volume=48|issue=8|pages=895–903|doi=10.1038/ng.3605|pmid=27376235|issn=1546-1718|pmc=5058437}}

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Category:1951 births

Category:Living people

Category:People educated at Alleyn's School

Category:Alumni of King's College London

Category:Fellows of the Royal Society

Category:Fellows of Brasenose College, Oxford

Category:British haematologists