Douglas R. Green
{{Short description|American immunologist}}
{{Infobox scientist
| name = Douglas R. Green
| birth_name = Douglas R Green
| image = File:Doug_Green.jpg
| image_size = 180px
| birth_date = {{birth year and age|1955|2}}
| birth_place = United States
| death_date =
| death_place =
| death_cause =
| field = Cell Death, Cancer Biology, Immunology
| work_institution = St. Jude Children's Research Hospital
| notable_students =
| alma_mater =
| thesis_title = Contrasuppression: An Immunoregulatory T Cell Activity
| thesis_url = https://www.proquest.com/docview/303198434
| thesis_year = 1981
| doctoral_advisor = Richard K. Gershon
| postdoctoral_advisor =
| known_for = Apoptosis research
| prizes =
| website = {{URL|http://www.stjude.org/green}}
}}
Douglas Green (born 1955), is an American biologist. He holds the Peter C. Doherty Endowed Chair of Immunology in St. Jude Children's Research Hospital. His research has focused on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the molecular events directing the death of the cell. Green was editor in chief of the journal Oncogene from 2009-2016, is a Deputy Editor of the journal "Science Advances" and the author of the book Cell Death, Means To An End.
Education
Green attended Ashland High School in 1973.{{Cite web | url=https://www.metrowestdailynews.com/story/news/2009/10/05/ashland-plans-salute/41353709007/ | title=Ashland plans salute }} He then graduated magna cum laude from the Yale University with a Bachelor of Science in Biology in 1977. After training at the Massachusetts Institute of Technology for the next two years, Green graduated from Yale with a PhD in 1981, where he studied immunology with Richard K. Gershon.
Green joined the faculty at the University of Alberta in 1985.{{cite web|url=https://iuis2019.org/major-symposium-speaker-douglas-green/ |accessdate=11 July 2019 |title=Major Symposium Speaker: Douglas Green |publisher=International Congress of Immunology}} In 1990, Green moved to the La Jolla Institute for Allergy and Immunology, where he became Head of the Division of Cellular Immunology. In 2005, he moved to St. Jude Children's Research Hospital to become the Peter C. Doherty Endowed Chair of the Department of Immunology.{{cite web|url=https://www.stjude.org/green |accessdate=11 July 2019 |title=Douglas R. Green, PhD |publisher=St Jude Children's Research Hospital}}
Research
After many studies on immunological tolerance, Green's work on cell death began with his discovery of activation-induced apoptosis in T lymphocytes,{{Cite journal | pmid = 2786609| year = 1989| last1 = Shi| first1 = Y. F.| title = Cyclosporin a inhibits activation-induced cell death in T-cell hybridomas and thymocytes| journal = Nature| volume = 339| issue = 6226| pages = 625–6| last2 = Sahai| first2 = B. M.| last3 = Green| first3 = D. R.| s2cid = 13603645| doi = 10.1038/339625a0| bibcode = 1989Natur.339..625S}}{{Cite journal
| pmid = 1691753
| year = 1990
| last1 = Shi
| first1 = Y. F.
| title = Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation
| journal = Journal of Immunology
| volume = 144
| issue = 9
| pages = 3326–33
| last2 = Szalay
| first2 = M. G.
| last3 = Paskar
| first3 = L
| last4 = Sahai
| first4 = B. M.
| last5 = Boyer
| first5 = M
| last6 = Singh
| first6 = B
| last7 = Green
| first7 = D. R.
}} the role of c-Myc in this process{{Cite journal | pmid = 1378649| year = 1992| last1 = Shi| first1 = Y| title = Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas| journal = Science| volume = 257| issue = 5067| pages = 212–4| last2 = Glynn| first2 = J. M.| last3 = Guilbert| first3 = L. J.| last4 = Cotter| first4 = T. G.| last5 = Bissonnette| first5 = R. P.| last6 = Green| first6 = D. R.| doi=10.1126/science.1378649| bibcode = 1992Sci...257..212S}} and the finding that Bcl-2 cooperates with Myc in oncogenesis by blocking apoptosis.{{Cite journal | pmid = 1406975| year = 1992| last1 = Bissonnette| first1 = R. P.| title = Apoptotic cell death induced by c-myc is inhibited by bcl-2| journal = Nature| volume = 359| issue = 6395| pages = 552–4| last2 = Echeverri| first2 = F| last3 = Mahboubi| first3 = A| last4 = Green| first4 = D. R.| s2cid = 4276740| doi = 10.1038/359552a0| bibcode = 1992Natur.359..552B}} More recently, he discovered the process of LC3-associated phagocytosis, which links the autophagy pathway to phagosome maturation.{{Cite journal | pmid = 18097414| year = 2007| last1 = Sanjuan| first1 = M. A.| title = Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis| journal = Nature| volume = 450| issue = 7173| pages = 1253–7| last2 = Dillon| first2 = C. P.| last3 = Tait| first3 = S. W.| last4 = Moshiach| first4 = S| last5 = Dorsey| first5 = F| last6 = Connell| first6 = S| last7 = Komatsu| first7 = M| last8 = Tanaka| first8 = K| last9 = Cleveland| first9 = J. L.| last10 = Withoff| first10 = S| last11 = Green| first11 = D. R.| s2cid = 4406473| doi = 10.1038/nature06421| bibcode = 2007Natur.450.1253S}} Other areas of interest include regulated necrosis,{{Cite journal | pmid = 24813850| pmc = 4068710| year = 2014| last1 = Dillon| first1 = C. P.| title = RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3| journal = Cell| volume = 157| issue = 5| pages = 1189–202| last2 = Weinlich| first2 = R| last3 = Rodriguez| first3 = D. A.| last4 = Cripps| first4 = J. G.| last5 = Quarato| first5 = G| last6 = Gurung| first6 = P| last7 = Verbist| first7 = K. C.| last8 = Brewer| first8 = T. L.| last9 = Llambi| first9 = F| last10 = Gong| first10 = Y. N.| last11 = Janke| first11 = L. J.| last12 = Kelliher| first12 = M. A.| last13 = Kanneganti| first13 = T. D.| last14 = Green| first14 = D. R.| doi = 10.1016/j.cell.2014.04.018}} metabolic reprogramming in T lymphocytes,{{Cite journal | pmid = 22195744| pmc = 3248798| year = 2011| last1 = Wang| first1 = R| title = The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation| journal = Immunity| volume = 35| issue = 6| pages = 871–82| last2 = Dillon| first2 = C. P.| last3 = Shi| first3 = L. Z.| last4 = Milasta| first4 = S| last5 = Carter| first5 = R| last6 = Finkelstein| first6 = D| last7 = McCormick| first7 = L. L.| last8 = Fitzgerald| first8 = P| last9 = Chi| first9 = H| last10 = Munger| first10 = J| last11 = Green| first11 = D. R.| doi = 10.1016/j.immuni.2011.09.021}} and the function of the tumor suppressor, p53.{{Cite journal | pmid = 14963330| year = 2004| last1 = Chipuk| first1 = J. E.| title = Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis| journal = Science| volume = 303| issue = 5660| pages = 1010–4| last2 = Kuwana| first2 = T| last3 = Bouchier-Hayes| first3 = L| last4 = Droin| first4 = N. M.| last5 = Newmeyer| first5 = D. D.| last6 = Schuler| first6 = M| last7 = Green| first7 = D. R.| s2cid = 9793389| doi = 10.1126/science.1092734| bibcode = 2004Sci...303.1010C}} As of 2014 he had published many chapters and books and over 500 papers, making him one of the world's most cited molecular biologists.{{cite web |url=http://researchanalytics.thomsonreuters.com/institution/ |title=ISI - highlycited.com |website= |accessdate=2015-02-06 }}{{Dead link|date=February 2024 |bot=InternetArchiveBot |fix-attempted=yes }} He is listed in:
- ISI "highly cited" (Immunology 2003)
- ISI "highly cited" (Molecular Biology/Genetics 2014)
Recognition
Green has received many awards, among these the E.J. Boell Award (Biology) (Yale, 1977), the J.S. Nicholas Award (Zoology) (Yale, 1981), Alberta Heritage Scholar (AHFMR 1985-1990), the Outstanding Teacher Award (Alberta, 1990), Ashland Public School System Hall of Fame[http://www.metrowestdailynews.com/article/20081211/News/312119907 Hall of Fame] (Ashland, MA 1998), MERIT Award, NIGMS (2002), the International Cell Death Society Prize[http://www.celldeath-apoptosis.org/oursoci/awardees.html?showall=&start=9 International Cell Death Society Prize] {{webarchive |url=https://web.archive.org/web/20150225060425/http://www.celldeath-apoptosis.org/oursoci/awardees.html?showall=&start=9 |date=February 25, 2015 }} (2009), Einstein Professorship (China, 2011). He is an Honorary Fellow of Trinity College, Dublin (2010)[https://www.tcd.ie/Secretary/FellowsScholars/2010/#DouglasGreen Trinity College Fellows Scholars 2010] and Dottore Honoris Causa of Rome University Tor Vergata (2016).[http://web.uniroma2.it/module/name/Content/newlang/italiano/navpath/HOM/action/showpage/content_id/21638 Dottorato Honoris Causa in 'Biochimica e Biologia Molecolare' a Douglas R. Green] Green was elected to the Royal Society of Canada in 2018, the United States National Academy of Sciences in 2020,
[http://www.nasonline.org/news-and-multimedia/news/2020-nas-election.html News from the National Academy of Sciences] and the American Association for the Advancement of Science (AAAS) Fellow in 2021.
[https://www.aaas.org/page/2021-fellows 2021 AAAS Fellows] In 1998, he was inducted into the Ashland High School Hall of Fame.
References
{{Reflist|30em}}
External links
- {{official website|http://www.stjude.org/green }}
- [http://www.the-scientist.com/?articles.view/articleNo/18391/title/Identifying-1996-s-Most-Cited-Articles-And-Hottest-Authors/ Identifying 1996's Most-Cited Articles And Hottest Authors]
{{Authority control}}
{{DEFAULTSORT:Green, Douglas R.}}
Category:Yale University alumni
Category:American cancer researchers
Category:People from Ashland, Massachusetts