Draft:Greg Neely

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{{AFC comment|1=Delete all of the "media outlets" that are not about Neely. Some do not even mention him by name. Others are quoting what he said, but no content about him other than to identify his academic affiliation. David notMD (talk) 12:22, 13 January 2025 (UTC)}}

{{AFC comment|1=Wikipedia articles should be written neutrally, not try to promote someone. QuicoleJR (talk) 19:37, 6 January 2025 (UTC)}}

{{AFC comment|1=See WP:NOTCV. ☮️Counter-Strike:Mention 269🕉️^{(🗨️ ● ✉️ ● 📔)} 05:25, 2 January 2025 (UTC)}}

{{AFC comment|1=Wikipedia cannot reference itself. Theroadislong (talk) 14:35, 30 December 2024 (UTC)}}

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{{Infobox scientist

| name = Greg Neely

| image = Greg Neely.jpg

| caption = Neely at a conference in 2024

| birth_date = {{Birth date|1974|11|05}}

| birth_place = Toronto, Canada

| nationality = Canadian-Australian

| alma_mater = University of Calgary

| fields = Functional genomics, Pain, Neuroscience, Immunology

| workplaces = Institute of Molecular Biotechnology, Garvan Institute of Medical Research, University of Sydney

}}

Greg Neely is a Canadian-Australian scientist specialising in functional genomics. He is Head of the Dr. John and Anne Chong Lab at the Charles Perkins Centre, University of Sydney. His research showed neuropathic pain-like behaviour in insects,{{cite journal |last1=Khuong |first1=TM |title=Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. |journal=Science Advances |date=2019 |volume=5 |issue=7 |page=eaaw4099 |doi=10.1126/sciadv.aaw4099 |pmid=31309148 |pmc=6620091 |bibcode=2019SciA....5.4099K }} the molecular basis of synesthesia,{{cite journal |last1=Neely |first1=GG |title=A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene |journal=Cell |date=2010 |volume=143 |issue=4 |pages=628–38 |doi=10.1016/j.cell.2010.09.047|pmid=21074052 |pmc=3040441 }} and developed new antidotes to venoms from cobra snakes{{cite journal |last1=Du |first1=TY |title=Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming |journal=Science Translational Medicine |date=2024 |volume=16 |issue=756 |page=eadk4802 |doi=10.1126/scitranslmed.adk4802|pmid=39018365 }} and box jellyfish.{{cite journal |last1=Lau |first1=MT |title=Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. |journal=Nature Communications |date=2019 |volume=10 |issue=1 |page=1655 |doi=10.1038/s41467-019-09681-1 |pmid=31040274 |pmc=6491561 |bibcode=2019NatCo..10.1655L |url=https://doi.org/10.1038/s41467-019-09681-1}}

Early life and education

Neely was born in Toronto, Canada and pursued his higher education at the University of Calgary. He earned a Bachelor of Science in Cellular, Molecular and Microbial Biology in 1997, followed by a PhD in Cellular Immunology under Christopher H. Mody.{{cite web |last1=Mody |first1=Christopher |title=Professor |url=https://cumming.ucalgary.ca/departments/microinfect/faculty/primary-members/christopher-mody |website=University of Calgary|date=27 January 2020 }} This was funded by the Loraine Award and focused on immunological mechanisms at the cellular level.{{cite journal |last1=Neely |first1=GG |title=Monocyte Surface-Bound IL-15 Can Function as an Activating Receptor and Participate in Reverse Signaling |journal=Journal of Immunology |date=2004 |volume=172 |issue=7 |pages=4225–34 |doi=10.4049/jimmunol.172.7.4225 |pmid=15034035 |url=https://doi.org/10.4049/jimmunol.172.7.4225}}{{cite journal |last1=Neely |first1=GG |title=Lipopolysaccharide-Stimulated or Granulocyte-Macrophage Colony-Stimulating Factor-Stimulated Monocytes Rapidly Express Biologically Active IL-15 on Their Cell Surface Independent of New Protein Synthesis |journal=Journal of Immunology |date=2001 |volume=167 |issue=9 |pages=5011–5017 |doi=10.4049/jimmunol.167.9.5011 |pmid=11673509 |url=https://doi.org/10.4049/jimmunol.167.9.5011}}

Career

After completing a postdoctoral fellowship in Austria (2003-10) with Josef Penninger at the Institute of Molecular Biotechnology, Neely joined the Garvan Institute of Medical Research in Sydney as a Faculty and Principal Research Fellow (2010-2015). In 2015, he moved to the University of Sydney, where he has continued his research into genomics and pain at the Charles Perkins Centre.

Research and discoveries

Neely's research program uses functional genomics to identify core molecular mechanisms that govern physiological systems. His primary research focus is chronic pain. He has identified hundreds of new pain genes, including TRPA1, an ancient pain receptor conserved across species.{{cite journal |last1=Neely |first1=GG |title=TrpA1 Regulates Thermal Nociception in Drosophila. |journal=PLOS ONE |date=2011 |volume=6 |issue=8 |page=e24343 |doi=10.1371/journal.pone.0024343 |doi-access=free |pmid=21909389 |pmc=3164203 |bibcode=2011PLoSO...624343N }} Neely demonstrated that insects can experience something like neuropathic pain, suggesting evolutionary conservation of pain responses. His research also contributed to understanding synesthesia by identifying molecular pathways linking sensory inputs.

In venom research, Neely's team developed new antidotes for cobra and box jellyfish venoms, using CRISPR screening to identify pathways targeted by repurposed drugs.

During the COVID-19 pandemic, Neely's group identified LRRC15, a lung protein that may provide protection against SARS-CoV-2, offering potential avenues for treatment {{cite journal |last1=Loo |first1=L |title=Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. |journal=PLOS Biology |date=2023 |volume=21 |issue=2 |page=e3001967 |doi=10.1371/journal.pbio.3001967 |doi-access=free |pmid=36757924 |pmc=9910744 }}. His lab also investigated artificial sweeteners' effects on metabolism, showing links between sucralose and increased food intake in fruit flies {{cite journal |last1=Wang |first1=QP |title=Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response |journal=Cell Metabolism |date=2016 |volume=24 |issue=1 |pages=75–90 |doi=10.1016/j.cmet.2016.06.010 |pmid=27411010 |url=https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30296-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116302960%3Fshowall%3Dtrue;}} {{cite journal |last1=Wang |first1=QP |title=Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake. |journal=Cell Metabolism |date=2017 |volume=26 |issue=2 |pages=279–280 |doi=10.1016/j.cmet.2017.07.002 |pmid=28768164 |url=https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(17)30423-0}}{{cite journal |last1=Wang |first1=QP |title=Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice. |journal=PLOS ONE |date=2018 |volume=13 |issue=7 |page=e0199080 |doi=10.1371/journal.pone.0199080 |doi-access=free |pmid=29975731 |pmc=6033410 |bibcode=2018PLoSO..1399080W }}

Awards and recognition

Neely has received NHMRC Career Development Fellowships and the NHMRC Marshall and Warren Award for innovative research {{cite web |title=NHMRC Marshall and Warren Ideas Grant (Innovation) Awards |url=https://www.nhmrc.gov.au/about-us/nhmrc-awards/research-excellence-awards#:~:text=The%20Marshall%20and%20Warren%20Awards,recipient%20of%20an%20Ideas%20Grant.}}. His research has been featured in major media outlets like the BBC {{Cite web|url=https://www.bbc.com/news/articles/cv2gwv284y1o|title=Cobra venom neutralised by common blood-thinning drug Heparin|website=www.bbc.com}}{{cite web |title=Could artificial sweeteners make people more hungry? |work=BBC News |date=13 July 2016 |url=https://www.bbc.com/news/health-36772303}}, CNN {{cite web |title= Potential antidote discovered for world’s most venomous sea creature, the box jellyfish |date=May 2019 |url=https://edition.cnn.com/2019/05/01/health/box-jellyfish-antidote-scn-intl/index.html}}, The Guardian {{cite web |title=The Guardian, article |website=TheGuardian.com |date=20 July 2019 |url=https://www.theguardian.com/science/2019/jul/21/taking-the-sting-out-australian-gene-editing-is-crossing-the-pain-threshold |last1=Zhou |first1=Naaman }}{{cite web |title=The Guardian, article, 2023 |website=TheGuardian.com |date=9 February 2023 |url=https://www.theguardian.com/australia-news/2023/feb/09/crazy-interesting-findings-by-australian-researchers-may-reveal-key-to-covid-immunity |last1=Davey |first1=Melissa }}, France 24 {{cite web |title=France 24 article, 2019 |date=May 2019 |url=https://www.france24.com/en/20190501-australian-scientists-find-antidote-deadly-box-jellyfish-sting}}, Sydney Morning Herald {{cite web |title=The end of venom? Sydney scientists find new cure for flesh-eating snake bites |url=https://www.smh.com.au/national/nsw/the-end-of-venom-sydney-scientists-find-new-cure-for-flesh-eating-snake-bites-20240717-p5juge.html |website=Sydney Morning Herald|date=17 July 2024 }}{{cite web |title=Curing cancer, designer babies, supersoldiers: How will gene-editing change us? |url=https://www.smh.com.au/national/curing-cancer-designer-babies-supersoldiers-how-will-gene-editing-change-us-20210511-p57qqt.html |website=Sydney Morning Herald|date=4 July 2021 }}, Scientific American {{cite web |title=Scientific American article, 2016 |website=Scientific American |url=https://www.scientificamerican.com/article/how-artificial-sweeteners-may-cause-us-to-eat-more/}}, The Lancet {{Cite web|url=https://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(23)00154-8.pdf|title=Research in brief: |website=www.thelancet.com}}, Science {{Cite web|url=https://www.science.org/content/article/common-blood-thinners-could-combat-cobra-venom|title=Common blood thinners could combat cobra venom|website=www.science.org}}{{Cite web|url=https://www.science.org/content/article/researchers-may-have-antidote-deadliest-jellyfish-sting-earth|title=Researchers may have an antidote for the deadliest jellyfish sting on Earth|website=www.science.org}} and Nature {{cite journal |title=Nature article |journal=Nature |date=21 November 2024 |doi=10.1038/d41586-024-03818-z |url=https://www.nature.com/articles/d41586-024-03818-z |last1=Willyard |first1=Cassandra |pmid=39572669 }}{{cite journal |title=Nature article, 2016 |journal=Nature |date=July 2016 |volume=535 |issue=7611 |pages=203 |doi=10.1038/535203e |url=https://www.nature.com/articles/535203e}}.

External links

[https://www.sydney.edu.au/science/about/our-people/academic-staff/greg-neely.html#collapseprofileresearchinterest Professor Greg Neely, University of Sydney profile page]
[https://www.ncbi.nlm.nih.gov/myncbi/graham.neely.1/bibliography/public/ NCBI Bibliography]