E. Yvonne Jones

{{short description|Director of the Cancer Research UK Receptor Structure Research Group}}

{{For|the Canadian MP|Yvonne Jones}}

{{Use dmy dates|date=April 2022}}

{{Infobox scientist

| name = Yvonne Jones

| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}}

| birth_name = Edith Yvonne Jones

| image = Yvonne Jones Royal Society.jpg

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| caption = Jones in 2017

| birth_date = {{birth year and age |1960}}

| birth_place = Oswestry, England

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| fields = Structural biology

| workplaces = University of Edinburgh
University of Oxford

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| education = Llanfyllin High School

| alma_mater = University of Oxford (BA, DPhil)

| thesis_title = Structural and dynamic studies on biological macromolecules

| thesis_url = https://solo.bodleian.ox.ac.uk/permalink/44OXF_INST/35n82s/alma990161563330107026

| thesis_year = 1985

| doctoral_advisor = Andrew Miller
David Chilton Phillips

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| notable_students = Doryen Bubeck

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| awards = {{Plainlist|

  • Royal Society University Research Fellow (1991-2001)
  • Descartes Prize (2002){{citation needed|date=December 2017}}
  • EMBO Membership (2007){{cite web|location=Heidelberg|url=http://people.embo.org/profile/e-yvonne-jones |website=people.embo.org |title=EMBO People: E. Yvonne Jones |url-status=dead |archive-url=https://web.archive.org/web/20170201000506/http://people.embo.org/profile/e-yvonne-jones|author=Anon|year=2007|archive-date=2017-02-01 }}}}

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Edith Yvonne Jones (born 1960) is a British molecular biologist who is director of the Cancer Research UK Receptor Structure Research Group at the University of Oxford{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/e-yvonne-jones |author=Anon|year=2017|title=Professor E. Yvonne Jones FRS FMedSci - Nuffield Department of Medicine |website=ndm.ox.ac.uk |access-date=2017-06-09 |url-status=dead |archive-url=https://web.archive.org/web/20170426123443/https://www.ndm.ox.ac.uk/principal-investigators/researcher/e-yvonne-jones |archive-date=2017-04-26 }}{{cite web|title=Professor Yvonne Jones FMedSci FRS |url=https://royalsociety.org/people/yvonne-jones-13398/ |website=royalsociety.org |publisher=Royal Society |location=London |author=Anon |year=2017 |url-status=dead |archive-url=https://web.archive.org/web/20170505140158/https://royalsociety.org/people/yvonne-jones-13398/ |archive-date=2017-05-05 }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{blockquote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}}{{Google scholar id}}{{Scopus id}} and a Fellow of Jesus College, Oxford. She is widely known for her research on the molecular biology of cell surface receptors and signalling complexes.{{cite web|url=https://www.strubi.ox.ac.uk/research/e-yvonne-jones|title=The Division of Structural Biology at the University of Oxford (STRUBI)|website=www.strubi.ox.ac.uk|access-date=2018-05-02|archive-url=https://web.archive.org/web/20181208095540/https://www.strubi.ox.ac.uk/research/e-yvonne-jones|archive-date=2018-12-08|url-status=dead}}{{cite journal | doi=10.1074/JBC.M110.177394 | doi-access=free | title=The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease | date=2011 | last1=Reijns | first1=Martin A.M. | last2=Bubeck | first2=Doryen | last3=Gibson | first3=Lucien C.D. | last4=Graham | first4=Stephen C. | last5=Baillie | first5=George S. | last6=Jones | first6=E. Yvonne | last7=Jackson | first7=Andrew P. | journal=Journal of Biological Chemistry | volume=286 | issue=12 | pages=10530–10539 | pmid=21177854 | pmc=3060506 }}

Early life and education

Jones was born in 1960 in Oswestry, Shropshire, England.{{Who's Who | author=Anon| title=Jones, Prof. (Edith) Yvonne | id = U289289 | year = 2025 | doi =10.1093/ww/9780199540884.013.289289 | edition = online Oxford University Press|location=Oxford}} She was educated at Llanfyllin High School in Wales. She earned a Bachelor of Arts degree in Physics from the University of Oxford where she was an undergraduate student of Jesus College, Oxford in 1982.{{cite web|author=Anon|year=2017|title=Yvonne Jones Biography at Jesus College, Oxford |url=http://www.jesus.ox.ac.uk/people/professor-e-yvonne-jones |website=jesus.ox.ac.uk |url-status=dead |archive-url=https://web.archive.org/web/20170413051350/http://www.jesus.ox.ac.uk/people/professor-e-yvonne-jones |archive-date=2017-04-13 }} She was awarded a Doctor of Philosophy degree from Oxford in 1985 for structural and dynamic studies of biological macromolecules supervised by Andrew Miller and David Chilton Phillips.{{cite thesis|degree=DPhil|publisher=University of Oxford|title=Structural and dynamic studies on biological macromolecules|first=Edith Yvonne|last=Jones|date=1985|url=https://solo.bodleian.ox.ac.uk/permalink/44OXF_INST/35n82s/alma990161563330107026|website=bodleian.ox.ac.uk|oclc=863529476|id={{EThOS|uk.bl.ethos.371551}}}}

Research and career

During postdoctoral research at the University of Edinburgh Jones performed neutron scattering experiments at the Institut Laue–Langevin in Grenoble to investigate the properties of collagen. She subsequently returned to Oxford to learn protein crystallography, and determined one of the first structures of a cytokine, tumour necrosis factor (TNF) with David Stuart.{{cite journal|last1=Jones|first1=E. Y.|last2=Stuart|first2=D. I.|last3=Walker|first3=N. P. C.|title=Structure of tumour necrosis factor|journal=Nature|volume=338|issue=6212|year=1989|pages=225–228|issn=0028-0836|doi=10.1038/338225a0|pmid=2922050|bibcode=1989Natur.338..225J|s2cid=4260148}} {{closed access}} During her research, Jones contributed to the Medical Research Council (MRC) HIV/AIDS programs investigating the structure of reverse transcriptase for the development of antiviral drugs.{{cite journal|last1=Ren|first1=Jingshan|last2=Esnouf|first2=Robert|last3=Garman|first3=Elspeth|last4=Somers|first4=Donald|last5=Ross|first5=Carl|last6=Kirby|first6=Ian|last7=Keeling|first7=James|last8=Darby|first8=Graham|last9=Jones|first9=Yvonne|last10=Stuart|first10=David|last11=Stammers|first11=David|title=High resolution structures of HIV-1 RT from four RT–inhibitor complexes|journal=Nature Structural & Molecular Biology|volume=2|issue=4|year=1995|pages=293–302|issn=1545-9993|doi=10.1038/nsb0495-293|pmid=7540934|s2cid=34618424}} {{closed access}} In 1991 Yvonne started her own research laboratory at the University of Oxford funded by a Royal Society University Research Fellowship (URF) until 2001. In 1999 Yvonne co-founded the Division of Structural Biology (STRUBI) at Oxford. {{As of|2017}}, she is joint head of STRUBI and Deputy Director of the Wellcome Trust Centre for Human Genetics.{{Cite web|url=https://www.medsci.ox.ac.uk/study/graduateschool/supervisors/e-y-jones|title=E. Yvonne Jones: University of Oxford, Medical Sciences Division|website=medsci.ox.ac.uk|language=en|access-date=2017-06-09}}{{EuropePMC|ORCID=0000-0002-3834-1893}}

=Awards and honours=

Jones was elected a Fellow of the Royal Society (FRS) in 2017. She was also elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2003,{{citation needed|date=December 2017}} awarded the Descartes Prize by the European Union in 2002{{citation needed|date=December 2017}} and awarded EMBO Membership in 2007. She was elected a Fellow of the Learned Society of Wales in 2022.{{Cite web |last=Wales |first=The Learned Society of |title=Yvonne Jones |url=https://www.learnedsociety.wales/fellow/yvonne-jones/ |access-date=2023-08-30 |website=The Learned Society of Wales |language=en-US}}

References