EAF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene.{{cite journal | vauthors = Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ | title = ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties | journal = Blood | volume = 101 | issue = 6 | pages = 2355–62 |date=Feb 2003 | pmid = 12446457 | doi = 10.1182/blood-2002-06-1664 | doi-access = free }}{{cite journal | vauthors = Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z | title = Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer | journal = Cancer Res | volume = 63 | issue = 15 | pages = 4698–704 |date=Aug 2003 | pmid = 12907652 }}{{cite web | title = Entrez Gene: EAF2 ELL associated factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55840}} It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins.{{Cite journal |last=Simone |first=Federico |last2=Luo |first2=Roger T. |last3=Polak |first3=Paul E. |last4=Kaberlein |first4=Joseph J. |last5=Thirman |first5=Michael J. |date=2003-03-15 |title=ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties |url=https://ashpublications.org/blood/article/101/6/2355/106508/ELL-associated-factor-2-EAF2-a-functional-homolog?form=MG0AV3 |journal=Blood |volume=101 |issue=6 |pages=2355–2362 |doi=10.1182/blood-2002-06-1664 |issn=0006-4971|url-access=subscription }}

References

{{cite journal | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Saso K, Ito T, Natori S, Sekimizu K |title=Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II |journal=J. Biochem. |volume=133 |issue= 4 |pages= 493–500 |year= 2004 |pmid= 12761297 |doi=10.1093/jb/mvg065 }}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
{{cite journal | vauthors=Kong SE, Banks CA, Shilatifard A |title=ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 29 |pages= 10094–8 |year= 2005 |pmid= 16006523 |doi= 10.1073/pnas.0503017102 | pmc=1177379 |bibcode=2005PNAS..10210094K |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Xiao W, Jiang F, Wang Z |title=ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation |journal=Prostate |volume=66 |issue= 1 |pages= 1–12 |year= 2006 |pmid= 16114057 |doi= 10.1002/pros.20309 |s2cid=32749490 }}
{{cite journal | vauthors=Jiang F, Ai J, Xiao W, Wang Z |title=FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity |journal=Cancer Lett. |volume=253 |issue= 2 |pages= 265–72 |year= 2007 |pmid= 17395368 |doi= 10.1016/j.canlet.2007.02.003 | pmc=1989770 }}

EAF2

References

Further reading