EAL domain

{{Infobox protein family

| Symbol = EAL

| Name = EAL domain

| image = PDB 2bas EBI.jpg

| width =

| caption = crystal structure of the bacillus subtilis ykui protein, with an eal domain.

| Pfam = PF00563

| Pfam_clan =

| InterPro = IPR001633

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD = cd01948

}}

In molecular biology, the EAL domain is a conserved protein domain. It is found in diverse bacterial signalling proteins. It is named EAL after its conserved residues. The EAL domain may function as a diguanylate phosphodiesterase.{{cite journal |vauthors=Galperin MY, Nikolskaya AN, Koonin EV | title = Novel domains of the prokaryotic two-component signal transduction systems | journal = FEMS Microbiol. Lett. | volume = 203 | issue = 1 | pages = 11–21 |date=September 2001 | pmid = 11557134 | doi = 10.1016/S0378-1097(01)00326-3| doi-access = free }} The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.