EBI3

This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.{{cite journal | vauthors = Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA | title = The inhibitory cytokine IL-35 contributes to regulatory T-cell function | journal = Nature | volume = 450 | issue = 7169 | pages = 566–9 |date=November 2007 | pmid = 18033300 | doi = 10.1038/nature06306 | bibcode = 2007Natur.450..566C | s2cid = 4425281 }}

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.{{cite journal | vauthors = Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N | title = Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells | journal = Nat. Immunol. | volume = 7 | issue = 9 | pages = 929–36 |date=September 2006 | pmid = 16906167 | doi = 10.1038/ni1375 | s2cid = 32503719 }} IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.{{cite journal | vauthors = Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY | title = IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells | journal = Eur. J. Immunol. | volume = 37 | issue = 11 | pages = 3021–9 |date=November 2007 | pmid = 17874423 | doi = 10.1002/eji.200737810 | doi-access = free }}

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• {{UCSC genome browser|EBI3}}
• {{UCSC gene details|EBI3}}

{{Interleukin receptor modulators}}

{{gene-19-stub}}