EDC3
{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.{{cite journal | vauthors = Albrecht M, Lengauer T | title = Novel Sm-like proteins with long C-terminal tails and associated methyltransferases | journal = FEBS Lett | volume = 569 | issue = 1–3 | pages = 18–26 |date=Jun 2004 | pmid = 15225602 | doi = 10.1016/j.febslet.2004.03.126 | doi-access = free }}{{cite journal | vauthors = Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G | title = ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis | journal = Horm Metab Res | volume = 39 | issue = 5 | pages = 322–35 |date=May 2007 | pmid = 17533573 | doi = 10.1055/s-2007-977699 | s2cid = 10679128 }}{{cite web | title = Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80153}}
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]
References
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Further reading
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- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 | author2=Yoshitomo-Nakagawa K | author3=Maruyama K | last4=Suyama | first4=Akira | last5=Sugano | first5=Sumio }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 | author2=Smith FD | author3=Stark C | last4=Wells | first4=Clark D. | last5=Fawcett | first5=James P. | last6=Kulkarni | first6=Sarang | last7=Metalnikov | first7=Pavel | last8=O'Donnell | first8=Paul | last9=Taylor | first9=Paul |s2cid=2371325 | doi-access=free |bibcode=2004CBio...14.1436J }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Wan D |title=Large-scale cDNA transfection screening for genes related to cancer development and progression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 | author2=Gong Y | author3=Qin W | last4=Zhang | first4=P | last5=Li | first5=J | last6=Wei | first6=L | last7=Zhou | first7=X | last8=Li | first8=H | last9=Qiu | first9=X |bibcode=2004PNAS..10115724W |doi-access=free }}
- {{cite journal | vauthors=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905–15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 |doi-access= free }}
- {{cite journal | author=Beausoleil SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 | author2=Villén J | author3=Gerber SA | last4=Rush | first4=John | last5=Gygi | first5=Steven P |s2cid=14294292 }}
- {{cite journal | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 | author2=Chu P | author3=Elisma F | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }}
- {{cite journal | author=Tritschler F |title=A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting |journal=Mol. Cell. Biol. |volume=27 |issue= 24 |pages= 8600–11 |year= 2007 |pmid= 17923697 |doi= 10.1128/MCB.01506-07 | pmc=2169425 | author2=Eulalio A | author3=Truffault V | last4=Hartmann | first4=M. D. | last5=Helms | first5=S. | last6=Schmidt | first6=S. | last7=Coles | first7=M. | last8=Izaurralde | first8=E. | last9=Weichenrieder | first9=O. }}
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{{Post transcriptional modification}}
{{gene-15-stub}}