EI24

{{Short description|Protein-coding gene in the species Homo sapiens}}

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.{{cite journal | vauthors = Gu Z, Flemington C, Chittenden T, Zambetti GP | title = ei24, a p53 response gene involved in growth suppression and apoptosis | journal = Mol Cell Biol | volume = 20 | issue = 1 | pages = 233–41 |date=Jan 2000 | pmid = 10594026 | pmc = 85079 | doi =10.1128/MCB.20.1.233-241.2000 }}{{cite journal | vauthors = Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B | title = A model for p53-induced apoptosis | journal = Nature | volume = 389 | issue = 6648 | pages = 300–5 |date=Sep 1997 | pmid = 9305847 | doi = 10.1038/38525 | bibcode = 1997Natur.389..300P | s2cid = 4429638 }}{{cite web | title = Entrez Gene: EI24 etoposide induced 2.4 mRNA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9538}}

This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.

References

{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
{{cite journal | vauthors=Gu Z, Gilbert DJ, Valentine VA |title=The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9 |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3–4 |pages= 230–3 |year= 2000 |pmid= 10965130 |doi=10.1159/000015620 |s2cid=20889902 |display-authors=etal}}
{{cite journal | vauthors=Burns TF, Bernhard EJ, El-Deiry WS |title=Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo |journal=Oncogene |volume=20 |issue= 34 |pages= 4601–12 |year= 2001 |pmid= 11498783 |doi= 10.1038/sj.onc.1204484 |doi-access= |s2cid=33518914 }}
{{cite journal | vauthors=Gentile M, Ahnström M, Schön F, Wingren S |title=Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis |journal=Oncogene |volume=20 |issue= 53 |pages= 7753–60 |year= 2002 |pmid= 11753653 |doi= 10.1038/sj.onc.1204993 |doi-access= |s2cid=22664010 }}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

EI24

References

Further reading