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EIF1AY

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.{{cite journal | vauthors = Lahn BT, Page DC | title = Functional coherence of the human Y chromosome | journal = Science | volume = 278 | issue = 5338 | pages = 675–80 |date=Nov 1997 | pmid = 9381176 | doi =10.1126/science.278.5338.675 | bibcode = 1997Sci...278..675L }}{{cite web | title = Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked| url = https://www.ncbi.nlm.nih.gov/gene/?term=9086}}

Like its X-chromosomal counterpart EIF1AX, it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. It has one amino acid difference (M50L) from EIF1AX.

References

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Further reading

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  • {{cite journal | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-style=vanc| author2=Hao T | author3=Shaw C | display-authors=3 | last4=Patel | first4=Akash J. | last5=Szabó | first5=Gábor | last6=Rual | first6=Jean-François | last7=Fisk | first7=C. Joseph | last8=Li | first8=Ning | last9=Smolyar | first9=Alex | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Fortna A |title=Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution |journal=PLOS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 | pmc=449870 |name-list-style=vanc| author2=Kim Y | author3=MacLaren E | display-authors=3 | last4=Marshall | first4=Kriste | last5=Hahn | first5=Gretchen | last6=Meltesen | first6=Lynne | last7=Brenton | first7=Matthew | last8=Hink | first8=Raquel | last9=Burgers | first9=Sonya |doi-access=free }}
  • {{cite journal | vauthors=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 |doi-access= free }}
  • {{cite journal | author=Skaletsky H |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 |name-list-style=vanc| author2=Kuroda-Kawaguchi T | author3=Minx PJ | display-authors=3 | last4=Cordum | first4=Holland S. | last5=Hillier | first5=Ladeana | last6=Brown | first6=Laura G. | last7=Repping | first7=Sjoerd | last8=Pyntikova | first8=Tatyana | last9=Ali | first9=Johar |bibcode=2003Natur.423..825S | doi-access=free }}
  • {{cite journal | vauthors=Marintchev A, Kolupaeva VG, Pestova TV, Wagner G |title=Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1535–40 |year= 2003 |pmid= 12569173 |doi= 10.1073/pnas.0437845100 | pmc=149867 |bibcode=2003PNAS..100.1535M |doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}

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{{PDB Gallery|geneid=9086}}

{{Initiation factors}}

{{protein-stub}}