EIF2S2

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation.

Both eIF2α and eIF2β expression is regulated by the NRF1 transcription factor.{{cite journal | vauthors = Chiorini JA, Miyamoto S, Harkin SJ, Safer B | title = Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter | journal = J. Biol. Chem. | volume = 274 | issue = 7 | pages = 4195–201 |date=February 1999 | pmid = 9933616 | doi = 10.1074/jbc.274.7.4195 | doi-access = free }}

• eIF2

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{{Initiation factors}}

{{gene-20-stub}}