EIF3B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.{{cite journal | vauthors = Méthot N, Rom E, Olsen H, Sonenberg N | title = The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1110–6 | date = February 1997 | pmid = 8995410 | doi = 10.1074/jbc.272.2.1110 | doi-access = free }}{{cite web | title = Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8662}}
Interactions
EIF3B has been shown to interact with P70-S6 Kinase 1{{cite journal | vauthors = Holz MK, Ballif BA, Gygi SP, Blenis J | title = mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events | journal = Cell | volume = 123 | issue = 4 | pages = 569–80 | date = November 2005 | pmid = 16286006 | doi = 10.1016/j.cell.2005.10.024 | s2cid = 11118504 | doi-access = free }} and EIF3A.{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | date = October 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x | doi-access = free }}{{cite journal | vauthors = Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC | title = mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin | journal = EMBO J. | volume = 25 | issue = 8 | pages = 1659–68 | date = April 2006 | pmid = 16541103 | pmc = 1440840 | doi = 10.1038/sj.emboj.7601047 }}{{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8 | date = November 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 | doi-access = free }}
See also
References
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Further reading
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- {{cite journal | vauthors = Kirken RA, Rui H, Evans GA, Farrar WL | title = Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit | journal = J. Biol. Chem. | volume = 268 | issue = 30 | pages = 22765–70 | year = 1993 | doi = 10.1016/S0021-9258(18)41592-X | pmid = 7693677 | doi-access = free }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Asano K, Kinzy TG, Merrick WC, Hershey JW | title = Conservation and diversity of eukaryotic translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1101–9 | year = 1997 | pmid = 8995409 | doi = 10.1074/jbc.272.2.1101 | doi-access = free }}
- {{cite journal | vauthors = Chaudhuri J, Chakrabarti A, Maitra U | title = Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1 | journal = J. Biol. Chem. | volume = 272 | issue = 49 | pages = 30975–83 | year = 1997 | pmid = 9388245 | doi = 10.1074/jbc.272.49.30975 | doi-access = free }}
- {{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8 | year = 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 | doi-access = free }}
- {{cite journal | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free | last1 = Sanger Centre | first1 = The | last2 = Washington University Genome Sequencing Cente | first2 = The }}
- {{cite journal | vauthors = Lin L, Holbro T, Alonso G, Gerosa D, Burger MM | title = Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7 | journal = J. Cell. Biochem. | volume = 80 | issue = 4 | pages = 483–90 | year = 2001 | pmid = 11169732 | doi = 10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B | s2cid = 35848129 }}
- {{cite journal | vauthors = Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG | title = Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2326–37 | year = 2001 | pmid = 11331597 | pmc = 125443 | doi = 10.1093/emboj/20.9.2326 }}
- {{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | year = 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x | doi-access = free }}
- {{cite journal | vauthors = Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW | title = The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 8946–56 | year = 2004 | pmid = 14688252 | doi = 10.1074/jbc.M312745200 | doi-access = free }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
- {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
- {{cite journal | vauthors = ElAntak L, Tzakos AG, Locker N, Lukavsky PJ | title = Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit | journal = J. Biol. Chem. | volume = 282 | issue = 11 | pages = 8165–74 | year = 2007 | pmid = 17190833 | doi = 10.1074/jbc.M610860200 | s2cid = 2313046 | url = https://hal.archives-ouvertes.fr/hal-02018144/file/J.%20Biol.%20Chem.-2007-ElAntak-8165-74.pdf | doi-access = free }}
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{{Initiation factors}}
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