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EIF4ENIF1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.{{cite journal | vauthors = Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N | title = A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E | journal = EMBO J | volume = 19 | issue = 12 | pages = 3142–56 |date=Aug 2000 | pmid = 10856257 | pmc = 203362 | doi = 10.1093/emboj/19.12.3142 }}{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.{{cite web | title = Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56478| accessdate = }}

Interactions

EIF4ENIF1 has been shown to interact with EIF4E.

References

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Further reading

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  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Warner DR, Roberts EA, Greene RM, Pisano MM |title=Identification of novel Smad binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1185–90 |year= 2004 |pmid= 14651998 |doi=10.1016/j.bbrc.2003.11.049 }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |display-authors=etal |doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Andrei MA, Ingelfinger D, Heintzmann R |title=A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. |journal=RNA |volume=11 |issue= 5 |pages= 717–27 |year= 2005 |pmid= 15840819 |doi= 10.1261/rna.2340405 | pmc=1370757 |display-authors=etal}}
  • {{cite journal | vauthors=Ferraiuolo MA, Basak S, Dostie J |title=A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. |journal=J. Cell Biol. |volume=170 |issue= 6 |pages= 913–24 |year= 2005 |pmid= 16157702 |doi= 10.1083/jcb.200504039 | pmc=2171455 |display-authors=etal}}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLOS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 |doi-access=free }}
  • {{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Denoeud F, Kapranov P, Ucla C |title=Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. |journal=Genome Res. |volume=17 |issue= 6 |pages= 746–59 |year= 2007 |pmid= 17567994 |doi= 10.1101/gr.5660607 | pmc=1891335 |display-authors=etal}}

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