ELAV-like protein 3

{{Short description|Protein-coding gene in the species Homo sapiens}}

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.{{cite journal | vauthors = Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH | title = Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique | journal = Genomics | volume = 53 | issue = 3 | pages = 296–9 |date=Dec 1998 | pmid = 9799595 | doi = 10.1006/geno.1998.5468 }}{{cite web | title = Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1995}}

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Behrends U, Jandl T, Golbeck A |title=Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 669–77 |year= 2002 |pmid= 12209604 |doi= 10.1002/ijc.10550 |s2cid=35369661 |display-authors=etal|doi-access= }}
{{cite journal | vauthors=Park S, Myszka DG, Yu M |title=HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4765–72 |year= 2000 |pmid= 10848602 |doi=10.1128/MCB.20.13.4765-4772.2000 | pmc=85909 |display-authors=etal}}
{{cite journal | vauthors=Sakai K, Kitagawa Y, Hirose G |title=Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 2 |pages= 263–8 |year= 1999 |pmid= 10079173 |doi= 10.1006/bbrc.1999.0282 }}
{{cite journal | vauthors=Sakai K, Gofuku M, Kitagawa Y |title=A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 3 |pages= 1200–8 |year= 1994 |pmid= 7511893 |doi= 10.1006/bbrc.1994.1358 |display-authors=etal}}

ELAV-like protein 3

References

Further reading